Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

A CRADA for prostate disease research

Genomatix Software, the Uniformed Service University of the Health Sciences (USU), and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) have entered into a Cooperative Research and Development Agreement (CRADA) to extend their collaborative endeavors in prostate disease research.

22 Aug 2011

Cellular pathology of Lou Gehrig’s disease discovered

Researchers claim to have found a common cause behind the mysterious and deadly affliction of amyotrophic lateral sclerosis, better known as Lou Gehrig’s disease. The discovery could pave the way to new treatments for the devastating disorder whose victims include top physicist Professor Stephen Hawking.

22 Aug 2011

Women being screened too often for cervical cancer

Researchers based at the Centers for Disease Control and Prevention (CDC) found that many primary care doctors would bring women back for cancer screening annually - while recommendations generally call for a three-year wait after normal tests. This translates to higher costs to women and the healthcare system, as well as a risk of unnecessary treatment for false-positive test results - with very little additional cancer-catching benefit say experts. Lead author Katherine Roland said, “There's really no advantage to annual screening compared to screening every two or three years.”

18 Aug 2011

BTI completes SUGARDOWN human clinical study on blood sugar management

Boston Therapeutics, Inc. (BTI), a public company registered with the SEC and a developer of diabetes therapeutics, announced today the completion of a trial in healthy volunteers performed at the University of Sydney on SUGARDOWN, a dietary supplement designed to reduce post-meal elevation of blood glucose.

18 Aug 2011

Researchers isolate 17 novel antibodies against HIV

A team of researchers at and associated with the International AIDS Vaccine Initiative (IAVI), The Scripps Research Institute, the biotechnology company Theraclone Sciences and Monogram Biosciences Inc., a LabCorp company, report in the current issue of Nature the isolation of 17 novel antibodies capable of neutralizing a broad spectrum of variants of HIV, the virus that causes AIDS.

18 Aug 2011

Addiction – a brain disorder say experts

According to the American Society of Addiction Medicine, addiction is a chronic brain disorder like any other chronic brain disease such as obsessive-compulsive disorder and body dysmorphic disorder. Neurological abnormalities like disruptions in neurotransmission and the reward system drive addiction, the group said in a statement.

17 Aug 2011

U-M's epilepsy surgery could successfully treat patients with seizures

John Ligerakis was told he had to learn to live with seizures that had made it challenging for him to work or drive a car. A young professional just starting his career, Ligerakis was devastated about what his future might bring.

17 Aug 2011

Methodist, Philips partner to develop new imaging technology for infectious diseases

The Methodist Hospital Research Institute and Philips Healthcare are collaborating to develop new imaging technology that could be used to help identify the start -- and cause -- of an infectious disease epidemic.

From Philips Healthcare 17 Aug 2011

Seattle Children's receives Gates Foundation grant to complete development of Sea-PAP

Seattle Children's Research Institute today announced the receipt of a two-year, $2.3 million grant from the Bill & Melinda Gates Foundation to complete prototype development of its new respiratory support device, called Seattle Children's Positive Airway Pressure.

17 Aug 2011

Drug SLM3 prevents multiplication of tumor cells

Tumors that do not respond to chemotherapy are the target of a cancer therapy that prevents the function of two enzymes in mouse tumor cells, according to Pennsylvania medical researchers.

17 Aug 2011

Flexible-fiber CO2 laser-assisted ablation safe for endoscopic assisted transsphenoidal craniotomies

A new study has shown the Flexible-Fiber CO2 laser to safely cut and coagulate during endoscopic assisted transsphenoidal craniotomies (TSC) without the line of sight problems encountered with conventional CO2 lasers.

17 Aug 2011

Gene therapy cocktail can treat inherited diseases with 'misfolded' proteins

In a kind of molecular gymnastics, scientists at the University of North Carolina at Chapel Hill School of Medicine have devised a gene therapy cocktail that has the potential to treat some inherited diseases associated with "misfolded" proteins.

16 Aug 2011

Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma

Researchers at the University of Pittsburgh Cancer Institute (UPCI) have identified the oncoprotein that allows a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma.

16 Aug 2011

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia.

12 Aug 2011

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

Neuroblastoma, a malignant tumor that primarily affects infants and young children, is a leading cause of death for children with cancer. When amplification of the MYCN oncogene is found in the tumor, it usually indicates an aggressive tumor with rapid progression of the disease and a poor outcome. Thus MYCN amplification has come to be used as a prognostic indicator.

12 Aug 2011

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

New research led by Derya Unutmaz, MD associate professor, the Departments of Pathology, Medicine, and Microbiology at NYU School of Medicine and Mark Sundrud, PhD, of Tempero Pharmaceuticals, Inc., has identified a novel sensory pathway that modulates the potency of Th17 cell responses.

11 Aug 2011

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain.

10 Aug 2011

Researchers clarify role of two proteins key to T-cell development

In the latest issue of Nature, researchers at the Perelman School of Medicine at the University of Pennsylvania clarify the role of two proteins key to T-cell development.

9 Aug 2011

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice.

9 Aug 2011

Region Skåne selects LABVANTAGE for digitizing histopathological workflows

Region Skåne, has selected LABVANTAGE to deliver a $4 million turn-key solution for digitizing the histopathological workflows of the whole region. The system will possibly be the largest such installation in the world and among the first in northern Europe.

8 Aug 2011

Pathology News and Research

Further Reading

A CRADA for prostate disease research

Cellular pathology of Lou Gehrig’s disease discovered

Women being screened too often for cervical cancer

BTI completes SUGARDOWN human clinical study on blood sugar management

Researchers isolate 17 novel antibodies against HIV

Addiction – a brain disorder say experts

U-M's epilepsy surgery could successfully treat patients with seizures

Methodist, Philips partner to develop new imaging technology for infectious diseases

Seattle Children's receives Gates Foundation grant to complete development of Sea-PAP

Drug SLM3 prevents multiplication of tumor cells

Flexible-fiber CO2 laser-assisted ablation safe for endoscopic assisted transsphenoidal craniotomies

Gene therapy cocktail can treat inherited diseases with 'misfolded' proteins

Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Researchers clarify role of two proteins key to T-cell development

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

Region Skåne selects LABVANTAGE for digitizing histopathological workflows

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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