Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Hesperos' multi-organ model correctly determine cardiotoxic mechanisms

Hesperos Inc., pioneers of the "human-on-a-chip" in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo.

4 Jul 2019

A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019

Bruker announces novel phenomics solutions at Metabolomics 2019

At Metabolomics 2019, Bruker highlights innovative MS and NMR systems, and novel high-value solutions for molecular phenomics and clinical metabolomics.

From Bruker Daltonics 26 Jun 2019

Scientists discover new drug target for chemically induced Parkinson's disease

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson's disease.

23 Jun 2019

Researchers unlock mystery of immunosuppressive drug's biosynthesis

Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history.

22 Jun 2019

More insights into transport protein used by cancer cells

Certain cancer cells depend on exporting the metabolite lactate, which accumulates during the generation on energy. Lactate plays an important role in many biochemical and cellular processes.

21 Jun 2019

Eating fatty fish free of environmental pollutants could reduce type 2 diabetes risk

If the fatty fish we eat were free of environmental pollutants, it would reduce our risk of developing type 2 diabetes.

19 Jun 2019

Highlights and key takeaways from the 2019 Boston Bacterial Meeting (BBM)

Missed out on the 2019 Boston Bacterial Meeting (BBM)? Read our round-up of the key takeaways, areas of discussion, speakers and more.

19 Jun 2019

Cannabis use has increased and shifted from illicit market, research reveals

A new article published by researchers from University of Puget Sound and University of Washington reports that, based on analysis of public wastewater samples in at least one Western Washington population center, cannabis use both increased and substantially shifted from the illicit market since retail sales began in 2014.

18 Jun 2019

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.

14 Jun 2019

Bruker launches timsTOF fleX with ESI/MALDI capability for SpatialOMx at ASMS 2019

Bruker Daltonics has launched a novel timsTOF fleX mass spectrometer which combines ESI/MALDI capability for SpatialOMx on a single instrument.

From Bruker Daltonics 10 Jun 2019

Scientific discovery may lead to a treatment for lupus

A team of scientists has uncovered the structure of a regulatory complex that is involved in the release of cytokines and can be inhibited to treat lupus.

31 May 2019

Study reveals how air pollution affects the human body at the metabolite level

A new University at Buffalo study based on levels before, during and after the Beijing Olympics reveals how air pollution affects the human body at the level of metabolites.

30 May 2019

Metabolite of kratom alkaloid could be responsible for its pain relief benefits

Kratom is a Southeast Asian tree with a long history of use in traditional medicine.

30 May 2019

Low vitamin D associated with potentially harmful vaginal bacteria in pregnant black women

Vitamin D, sometimes known as the sunshine vitamin, has long been known to be important for a healthy pregnancy. Pregnant mothers take vitamin D supplements to ensure their own health and that of their unborn child.

29 May 2019

Scientists find how various chemical fixatives affect quality of tissue-engineered biomeshes

A group of scientists from Russia and Ireland found out how quality of tissue-engineered biomeshes is affected by various chemical fixatives.

29 May 2019

Study yields insights into evolutionary dynamics between bacteria and human hosts

Researchers have discovered that humans and great apes possess a receptor on their cells that detects metabolites from bacteria commonly found in fermented foods and triggers movement of immune cells.

From PLOS ONE 28 May 2019

New study explores link between traffic-related air pollution and childhood anxiety

Exposure to air pollution is a well-established global health problem associated with complications for people with asthma and respiratory disease, as well as heart conditions and an increased risk of stroke, and according to the World Health Organization, is responsible for millions of deaths annually.

21 May 2019

Whole grain cereals can provide health benefits by altering intestinal serotonin production

Adults consuming whole grain rye have lower plasma serotonin levels than people eating low-fiber wheat bread, according to a recent study by the University of Eastern Finland and the International Agency for Research on Cancer.

13 May 2019

Study provides first evidence of crosstalk between the heart and fat cells

Like sending a letter through the mail or a text over a cellular network, the heart can generate messages that travel long distances through the body.

10 May 2019