Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

GABA corrects both known causes of Type 1 diabetes

A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael's Hospital have found.

29 Jun 2011

Genetic tools that enable cell type-specific delivery hold promise for combating incurable neurologic diseases

Novel tools and methods for delivering therapeutic genes to cells in the central nervous system hold great promise for the development of new treatments to combat incurable neurologic diseases. Five of the most exciting developments in this rapidly advancing field are presented in a series of articles in the June issue of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc..

29 Jun 2011

Conventional Estrogen Receptor measurement methods may result in 10-20% false negative rate

A team of Yale Cancer Center researchers has confirmed that between 10-20% of breast cancers classified as Estrogen Receptor (ER) negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer. Its findings are published online in the June 28 Journal of Clinical Oncology.

28 Jun 2011

Scientists discover origin of Barrett's esophagus

Dr Frank McKeon, Senior Group Leader of the Stem Cell and Developmental Biology at A*STAR's Genome Institute of Singapore, and Principal Investigator Dr Wa Xian at A*STAR's Institute of Medical Biology, together with their counterparts from the Harvard Medical School, the Brigham and Women's Hospital in Boston, and the National University of Singapore, have made the striking finding that Barrett's esophagus work, published online in the journal Cell on 24 June 2011, is essential to developing therapeutics for esophageal cancer.

28 Jun 2011

Kindstar, Mayo Clinic enter multiyear agreement to offer specialized laboratory support

Mayo Clinic today announced that it has entered into a multiyear agreement with Wuhan Kindstar Globalgene Technology, Inc. (Kindstar) to provide specialized laboratory support based on provision of knowledge from Mayo Clinic's Department of Laboratory Medicine and Pathology and its reference laboratory, Mayo Medical Laboratories.

28 Jun 2011

Mayo Clinic signs agreement with Kindstar

Mayo Clinic today announced that it has entered into a multiyear agreement with Wuhan Kindstar Globalgene Technology, Inc. (Kindstar) to provide specialized laboratory support based on provision of knowledge from Mayo Clinic’s Department of Laboratory Medicine and Pathology and its reference laboratory, Mayo Medical Laboratories.

27 Jun 2011

Problems of unrecognized alcohol misuse among the elderly

The Royal College of Psychiatrists of London has published a report related primarily to problems of unrecognized alcohol misuse among the elderly. The report provides guidelines for psychiatrists and family physicians on how to find and how to treat elderly people with misuse of alcohol and drugs.

27 Jun 2011

Growth-braking tumor-suppressor gene slows growth of childhood brain tumors

Johns Hopkins researchers have found a likely explanation for the slow growth of the most common childhood brain tumor, pilocytic astrocytoma. Using tests on a new cell-based model of the tumor, they concluded that the initial process of tumor formation switches on a growth-braking tumor-suppressor gene, in a process similar to that seen in skin moles.

24 Jun 2011

Researchers discover new mechanism for origin of Barrett's esophagus

Researchers have discovered a new mechanism for the origin of Barrett's esophagus, an intestine-like growth in the esophagus that is triggered by chronic acid reflux and often progresses to esophageal cancer.

24 Jun 2011

AIS introduces Spectral karyotyping

AIS introduces Spectral karyotyping (SKY®) equipment, designed and manufactured by ASI, a leading developer of comprehensive solutions for pathology and cytogenetics. Spectral karyotyping (SKY®) is ASI’s novel addition to the cytogenetic tool kit. It is based on a unique electro-optical hardware that enables measuring the spectral image of a metaphase, previously stained, such that each chromosome class has a different color (created typically from different combinations of 5 or more basic dyes).

23 Jun 2011

MU and Coulter Foundation enter $5 million grant agreement for biomedical research

University of Missouri officials announced today a $5 million grant agreement with the Wallace H. Coulter Foundation, through the Foundation's Translational Partnership Award Program. The goal of the partnership is to develop technologies that will save, extend and improve patient lives and suffering from any disease or condition in any country around the world.

23 Jun 2011

Unraveling molecular dysfunction due to environmental toxin exposure

In a new article published in the journal Molecular Neurodegeneration, researchers at the University of Missouri School of Medicine take some of the first steps toward unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. Their discovery helps further explain recent NIH findings that demonstrate the link between Parkinson's disease and two particular pesticides - rotenone and paraquat.

23 Jun 2011

Caffeinated coffee boosts blood GCSF levels, protects against Alzheimer's

A yet unidentified component of coffee interacts with the beverage's caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer's disease.

22 Jun 2011

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

LifeCycle Pharma A/S today reported that the company's lead product candidate, LCP-Tacro, successfully demonstrated non-inferiority compared to tacrolimus in its Phase III trial, Study 3001.

21 Jun 2011

Rheonix, Mayo Clinic partner for genotyping test to assist warfarin sensitivity

Mayo Clinic today announced that it has reached an agreement with Rheonix, Inc. to collaborate on the performance of a genotyping test for warfarin sensitivity in clinical and research settings.

21 Jun 2011

Mayo Clinic announces collaboration on genotyping test for Warfarin sensitivity

Mayo Clinic today announced that it has reached an agreement with Rheonix, Inc. to collaborate on the performance of a genotyping test for warfarin sensitivity in clinical and research settings. The genotyping test will be available for all patients of Mayo Clinic and is the subject of ongoing research for improved anticoagulation therapy. Additionally, the test will be offered through Mayo Clinic’s reference laboratory, Mayo Medical Laboratories, to clients throughout the world.

20 Jun 2011

University of Texas professor recommends three postulates to find probable cause of AD

After more than 100 years following its pathologic description, the cause of Alzheimer's disease (AD) remains unknown. To test the validity of present and future proposals related to the probable cause of AD, three postulates, or necessary conditions, are recommended by Jack de la Torre, MD, PhD, Adjunct Professor of Psychology at the University of Texas, Austin, in an article published in the Journal of Alzheimer's Disease.

20 Jun 2011

New insight into progressive supranuclear palsy

There are new genetic clues on risk factors and biological causes of a rare neurodegenerative disease called progressive supranuclear palsy (PSP), according to a new study from an international genetics team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

20 Jun 2011

OptumHealth names Women & Infants as Center of Excellence for Reproductive Resource Services

Women & Infants Hospital of Rhode Island has been named a Center of Excellence for Reproductive Resource Services by OptumHealth, an independent audit company.

18 Jun 2011

Allos Therapeutics reports results from FOLOTYN pivotal trial against peripheral T-cell lymphoma

Allos Therapeutics, Inc. today reported results from a retrospective analysis of data from the Company's pivotal PROPEL trial which suggested that treatment with single-agent FOLOTYN may result in increased response rates and progression-free survival relative to the immediate prior line of therapy in patients with relapsed or refractory peripheral T-cell lymphoma.

17 Jun 2011

Pathology News and Research

Further Reading

GABA corrects both known causes of Type 1 diabetes

Genetic tools that enable cell type-specific delivery hold promise for combating incurable neurologic diseases

Conventional Estrogen Receptor measurement methods may result in 10-20% false negative rate

Scientists discover origin of Barrett's esophagus

Kindstar, Mayo Clinic enter multiyear agreement to offer specialized laboratory support

Mayo Clinic signs agreement with Kindstar

Problems of unrecognized alcohol misuse among the elderly

Growth-braking tumor-suppressor gene slows growth of childhood brain tumors

Researchers discover new mechanism for origin of Barrett's esophagus

AIS introduces Spectral karyotyping

MU and Coulter Foundation enter $5 million grant agreement for biomedical research

Unraveling molecular dysfunction due to environmental toxin exposure

Caffeinated coffee boosts blood GCSF levels, protects against Alzheimer's

Positive results from LCP-Tacro Phase III trial in stable kidney transplant recipients

Rheonix, Mayo Clinic partner for genotyping test to assist warfarin sensitivity

Mayo Clinic announces collaboration on genotyping test for Warfarin sensitivity

University of Texas professor recommends three postulates to find probable cause of AD

New insight into progressive supranuclear palsy

OptumHealth names Women & Infants as Center of Excellence for Reproductive Resource Services

Allos Therapeutics reports results from FOLOTYN pivotal trial against peripheral T-cell lymphoma

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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