Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Contribution of glycosaminoglycans to skeletal abnormalities in patients with lysosomal storage diseases demonstrated

A group led by Dr. Dieter Br-mme at the University of British Columbia has demonstrated that glycosaminoglycans (GAGs) contribute to skeletal abnormalities in patients with lysosomal storage diseases. Their report can be found in the November 2009 issue of The American Journal of Pathology.

21 Oct 2009

STR genotyping and p57 immunohistochemistry used to distinguish hydatidiform moles

Researchers from The Johns Hopkins Medical Institutions have used short tandem repeat (STR) genotyping and p57 immunohistochemistry to distinguish hydatidiform moles.

21 Oct 2009

Research shows exon-skipping drug may prove effective for treating Duchenne muscular dystrophy

An exon skipping PPMO has demonstrated dramatic effects in the prevention and treatment of severely affected, dystrophin and utrophin-deficient mice, preventing severe deterioration of the treated animals and extending their lifespan.

21 Oct 2009

Novartis' Tasigna capsules meets primary endpoint in comparison trial with Gleevec

Novartis announced today that Tasigna (nilotinib) 200 mg capsules met its primary endpoint in the first head-to-head comparison with the company's groundbreaking drug Gleevec (imatinib mesylate) tablets*. Tasigna produced faster and deeper responses than Gleevec when given as first-line therapy for adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. Tasigna was well tolerated in the study.

20 Oct 2009

Clonality analyses may lead to further understanding of hepatocarcinogenesis

Focal nodular hyperplasia (FNH) is a lesion found in an otherwise normal liver, and is considered to be parenchyma overgrowth responsive to increased blood flow secondary to vascular malformations.

20 Oct 2009

Gastrointestinal Associates emphasizes the need for colon screenings

As Washington policymakers debated health care reform on weekend talk shows, 48 people who are out of work or without health insurance received free colonoscopy screenings at Gastrointestinal Associates (GIA) here.

20 Oct 2009

Health Discovery Corporation granted additional patents for Recursive Feature Elimination using Support Vector Machines

Health Discovery Corporation is pleased to announce numerous additional issued patents and Notices of Allowance since its last press release describing its intellectual property portfolio. The Company now has a total of 37 issued patents, 4 Notices of Allowance and 30 pending patent applications.

20 Oct 2009

Physicians say thyroid surgery safe for older people

Thyroid surgery is safe for older patients, say physicians who found only slight differences in rates of complications and hospital readmissions in a multi-year study.

20 Oct 2009

New technique to treat metabolic disorders in babies while still in the womb

Researchers say a new development in cord blood transplants for inherited metabolic disorders may be curative for some babies who are treated while still in the womb.

20 Oct 2009

Scientists find cause for lupuslike disease in mice

Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease.

19 Oct 2009

Ardea Biosciences reports results of RDEA594 Phase 2a study for hyperuricemia and gout

Ardea Biosciences, Inc. announced additional positive results from the completed first cohort of an ongoing Phase 2a, proof-of-concept study of RDEA594, its lead product candidate for the treatment of hyperuricemia and gout.

19 Oct 2009

Breakthrough discovery by scientists may lead to a new treatment for Alzheimer's Disease

A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques-considered a hallmark of the disease-from patients' brains.

19 Oct 2009

New chromosomal abnormality in acute lymphoblastic leukemia

Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome.

19 Oct 2009

Novel HIV drug to be studied in cell cultures and patients

A $6 million, five-year federal grant to The Children's Hospital of Philadelphia Research Institute will enable researchers to investigate a novel approach in treating HIV infection---a unique class of drugs focused on developing therapies for psychological and neurological effects in AIDS.

19 Oct 2009

Physical therapists stress on definitive vestibular screenings and assessment measures for BITBI

Physical therapists are calling for definitive vestibular screenings and assessment measures for US military service members with blast-induced traumatic brain injuries (BITBI). According to a Scholarly Opinion Piece in the September issue of Physical Therapy, the scientific journal of the American Physical Therapy Association (APTA), vestibular rehabilitation must be included as part of successful treatment for those who have been injured by blasts and experience vestibular symptoms such as vertigo, gaze instability, and motion intolerance.

19 Oct 2009

International human migration needs to be factored into infectious disease policy

When people travel, bacteria and other infectious agents travel with them. As about a billion people cross international borders each year, many more billions of the bugs come along for the ride.

19 Oct 2009

Enzo Biochem to release a new catalog dealing with epigenetics and chromatin modification

Enzo Biochem, Inc. today said that its Life Sciences subsidiary will release a new catalog dealing with “Epigenetics & Chromatin Modification” at the Society for Neuroscience’s, Neuroscience 2009 conference, beginning October 17, 2009, in Chicago, Illinois.

15 Oct 2009

College of American Pathologists honours Dr. Kevin B. Dole as the 2009 Pathologist of the Year

Kevin B. Dole, MD, FCAP, was named the 2009 Pathologist of the Year at a ceremony held on October 11, 2009, in Washington DC at CAP '09 -- The Pathologists' Meeting(TM).

15 Oct 2009

Sangretech Biomedical signs amended license agreement with Bostwick Laboratories

Sangretech Biomedical LLC, a developer of dendritic cell therapies for cancer and infectious diseases, today announced it has executed an amended and restated license agreement with Bostwick Laboratories, Inc. providing Bostwick Scientific, the research division of Bostwick Laboratories, with exclusive rights to Sangretech’s dendritic cell technology in certain territories.

15 Oct 2009

UT Southwestern Medical Center awarded $15.7M NIH contract to develop a new virus database

The National Institutes of Health has awarded a $15.7 million contract to UT Southwestern Medical Center and Northrop Grumman Corp. to develop an open-access national online database and analysis resource center that will help scientists study and combat viruses such as those that cause hepatitis, encephalitis, smallpox, acute respiratory distress and dengue fever, as well as newly emerging pathogenic viruses.

15 Oct 2009

Pathology News and Research

Further Reading

Contribution of glycosaminoglycans to skeletal abnormalities in patients with lysosomal storage diseases demonstrated

STR genotyping and p57 immunohistochemistry used to distinguish hydatidiform moles

Research shows exon-skipping drug may prove effective for treating Duchenne muscular dystrophy

Novartis' Tasigna capsules meets primary endpoint in comparison trial with Gleevec

Clonality analyses may lead to further understanding of hepatocarcinogenesis

Gastrointestinal Associates emphasizes the need for colon screenings

Health Discovery Corporation granted additional patents for Recursive Feature Elimination using Support Vector Machines

Physicians say thyroid surgery safe for older people

New technique to treat metabolic disorders in babies while still in the womb

Scientists find cause for lupuslike disease in mice

Ardea Biosciences reports results of RDEA594 Phase 2a study for hyperuricemia and gout

Breakthrough discovery by scientists may lead to a new treatment for Alzheimer's Disease

New chromosomal abnormality in acute lymphoblastic leukemia

Novel HIV drug to be studied in cell cultures and patients

Physical therapists stress on definitive vestibular screenings and assessment measures for BITBI

International human migration needs to be factored into infectious disease policy

Enzo Biochem to release a new catalog dealing with epigenetics and chromatin modification

College of American Pathologists honours Dr. Kevin B. Dole as the 2009 Pathologist of the Year

Sangretech Biomedical signs amended license agreement with Bostwick Laboratories

UT Southwestern Medical Center awarded $15.7M NIH contract to develop a new virus database

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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