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Why Alzheimer’s DNA tests don’t treat all populations equally

A major global study tested whether European-derived polygenic risk scores (PGS) for Alzheimer’s disease can predict risk across diverse populations. While PGS performed well in many groups, it was less accurate in individuals of sub-Saharan African and Indian ancestry, highlighting the urgent need for more inclusive genetic data.

19 Jun 2025

APOE gene variants influence metabolic patterns linked to aging and Alzheimer’s risk

A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled "APOE genotype and biological age impact inter-omic associations related to bioenergetics."

12 Jun 2025

Study uncovers how HSV-1 disables the brain's antiviral defense

Infections caused by herpes simplex virus type 1 (HSV-1) can lead to HSV-1 encephalitis-a rare but deadly condition that inflames the brain.

3 Jun 2025

Blood test pinpoints early Alzheimer’s risk with high accuracy

Researchers evaluated a fully automated plasma biomarker panel to detect early amyloid-β accumulation in cognitively unimpaired adults at risk for Alzheimer’s disease. Plasma p-tau217/Aβ42 emerged as the most robust and accurate blood-based marker for identifying preclinical amyloid pathology.

26 May 2025

New Alzheimer's drug candidate reduces toxic protein and improves memory in mice models

As researchers work to improve treatment of Alzheimer's disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein.

20 May 2025

Adverse waist-to-height ratio trajectories during childhood linked to early cardiometabolic risk

New research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May) reveals that adverse waist-to-height ratio trajectories (a marker for central obesity) during childhood may increase cardiometabolic and cardiovascular risk at 10 years old.

11 May 2025

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

Getting active in midlife may boost brain resilience to Alzheimer’s

In cognitively healthy middle-aged adults at risk for Alzheimer’s disease, becoming physically active, especially in line with WHO guidelines, was linked to lower brain amyloid burden. Remaining sedentary was associated with reduced cortical thickness in brain regions vulnerable to AD.

1 May 2025

New blood test can improve heart disease risk prediction

For almost 60 years, measuring cholesterol levels in the blood has been the best way to identify individuals at high risk of cardiovascular disease.

28 Apr 2025

Age and sex shape Alzheimer’s blood biomarkers, study finds

ESTHER study found that non-modifiable factors like age, sex, and APOE ε4 status significantly influence blood biomarker levels linked to Alzheimer’s disease. GFAP and NfL levels, in particular, showed strong age- and sex-related patterns, with GFAP levels rising faster in women.

22 Apr 2025

Alzheimer's risk factors linked to cognition as early as young adulthood

A new study from Columbia University Mailman School of Public Health and the Columbia Butler Aging Center suggests that risk factors and biomarkers related to Alzheimer's disease are associated with cognition much earlier in life than previously recognized.

21 Apr 2025

EAT-Lancet planetary diet shows no dementia risk, may protect against Alzheimer’s

In a large Swedish study, researchers found that the environmentally sustainable EAT-Lancet diet does not increase dementia risk and may lower the risk of Alzheimer’s and all-cause dementia, particularly in people without the APOE ε4 gene. The findings support the integration of sustainable diets into dementia prevention strategies.

15 Apr 2025

High cholesterol may not signal heart disease risk in metabolically healthy people

The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, in collaboration with researchers across multiple institutions, has published a new study that challenges the long-held belief that high cholesterol correlates and even directly causes coronary artery disease, or plaque buildup in the arteries in metabolically healthy individuals.

7 Apr 2025

Mpox virus poses rising global epidemic and pandemic threat

Insufficient research on mpox hinders effective control strategies, emphasizing the need to understand its transmission and immune response mechanisms.

7 Apr 2025

What blueberries do and don’t do for your microbiome and heart

Regular blueberry consumption for 12 weeks enriched Coriobacteriales incertae sedis in the gut microbiota of older overweight adults. However, this microbial shift was not linked to significant improvements in cardiometabolic biomarkers.

31 Mar 2025

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota.

25 Mar 2025

Better heart health slows brain aging and lowers dementia risk, study finds

A JAMA Network Open study finds that better cardiovascular health (CVH) in older adults is linked to lower levels of neurodegenerative biomarkers, particularly neurofilament light chain (NfL). These benefits are consistent across races and especially impactful for individuals carrying Alzheimer's-related genetic risks.

16 Mar 2025