Disease Modeling News and Research

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Research could lead to a personalized approach for treating sickle cell disease

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research.

24 Mar 2021

Report: Probabilistic forecasts of the impact of vaccines and variants on the U.S. COVID trajectory

In a report summary released today Thomas McAndrew, a computational scientist and assistant professor at Lehigh University's College of Health includes probabilistic forecasts of the impact of vaccines and variants on the U.S. COVID trajectory over the next few weeks.

3 Mar 2021

Corning to highlight newest products in 3D cell culture portfolio at SLAS2021

Corning Incorporated will highlight its latest technologies that support the advancement of 3D cell culture, automation, and drug discovery at this year's virtual Society for Laboratory Automation and Screening (SLAS) conference on Jan. 25 through 27.

22 Jan 2021

Can the onset and end of an epidemic be predicted? A SARS-CoV-2 modeling case study

A recent study by researchers in France shows how differences in infection history and viral spread patterns are important factors in predicting the time course of a localized epidemic of SARS-CoV-2.

22 Jan 2021

RNA sequencing data reveals three major molecular subtypes of Alzheimer's disease

Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing.

7 Jan 2021

How effective have COVID-19 control measures been in the UK?

Researchers in the UK and Australia have shown that epidemiologic models accounting for people’s behavior outside of measures introduced to control the coronavirus disease-19 (COVID-19) pandemic improve estimates of how effective such interventions have been.

21 Dec 2020

How does the UK’s COVID-19 response compare to others in Europe?

Researchers modeled the health benefits and economic loss caused by coronavirus disease 2019 (COVID-19) in the UK and compared them to four other western European countries. Their results suggest the British Government’s response may outweigh the economic loss incurred.

17 Dec 2020

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

Meier-Gorlin syndrome, or MGS, is a rare genetic developmental disorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities. In severe cases, MGS results in miscarriages and stillbirths.

14 Dec 2020

Researchers develop analytical model to gauge SARS-CoV-2 transmission dynamics in schools

Research highlight the risk of virus spread in schools in the Netherlands. Since most schools across countries have resumed in-person or face-to-face classes, knowing the virus's risk and transmission dynamics in this context is crucial.

9 Dec 2020

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

8 Dec 2020

Study describes the early evolution of oral poliovirus vaccine

While the world reels from the spread of SARS-CoV2, the new coronavirus behind COVID-19, a much older and previously feared scourge--poliovirus--is close to being completely eradicated.

19 Nov 2020

Global collaboration provides a COVID-19 disease map

A collaboration of researchers from 120 different institutes across 30 countries including France, Germany, Australia, Japan, USA, India, Turkey, Brazil, and Canada initiated an effort to develop a COVID-19 Disease Map - a collection of computational models and diagrams of molecular mechanisms implicated in COVID-19.

2 Nov 2020

Scientists develop new model of coronavirus diffusion through a community

The coronavirus doesn't spread uniformly through a community.But in the world of disease modeling, many projections take a high-level approach to a geographic area, like a county or state, and forecast based on a general idea that a virus will take root and spread at an equal rate until it reaches its peak of infection.

30 Oct 2020

Tabba Heart Institute and IHME partner to improve cardiovascular health in Pakistan

Tabba Heart Institute and the Institute for Health Metrics and Evaluation at the University of Washington's School of Medicine are partnering to improve public knowledge and inform policymakers of cardiovascular health in Pakistan by collecting and sharing data, leveraging their expertise in health metrics sciences to provide more accurate estimates of the national and provincial burden of cardiovascular diseases in Pakistan.

28 Oct 2020

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Recently, a team of researchers from the University of California San Diego and The Scripps Research Institute, CA, USA, showed that an integrated stem cell-based disease modeling and computational approach is crucial for simulating the host immune response in fatal COVID-19 patients.

19 Oct 2020

NIH provides $9.3 million grant to create new Center for Precision Animal Modeling at UAB

A new Center for Precision Animal Modeling, or C-PAM, has been created at the University of Alabama at Birmingham, supported by a five-year, $9.3 million grant from the National Institutes of Health's Office of Research Infrastructure Programs.

9 Oct 2020

Viral loads peak before symptom onset in COVID-19

By reviewing published literature on viral loads and viral shedding, researchers found that viral loads for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)peak before symptoms are seen. This has substantial implications for prevention strategies.

5 Oct 2020

NIH awards grants for using bioengineered models to improve clinical trial design

Clinical Trials on a Chip researchers plan to build and test common and rare disease models to help improve the clinical trial process.

30 Sep 2020

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Gruthan Bioscience, LLC, a Medical University of South Carolina startup based in Charleston, South Carolina, received a Small Business technology Transfer (STTR) award from the National Heart, Blood and Lung Institute in August to take the next step in developing a novel class of cholesterol-lowering drugs to treat familial hypercholesterolemia.

24 Sep 2020

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Curi Bio today announced the Mantarray™ platform for human-relevant 3D engineered muscle tissue (EMT) analysis.

From Curi Bio 16 Sep 2020