Exhaustion News and Research

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What happens to your body during an ultramarathon? New study reveals key metabolic changes

This study tracked ultramarathon runners across 100 km, 160.9 km, and 230 km events to examine real-world metabolic, hormonal, and muscle stress responses. Severe energy deficits, muscle damage, and heterogeneous hormonal shifts were observed, with the greatest strain seen in the 230 km distance.

10 Dec 2025

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing terminal exhaustion and enhancing tumour control in mice. This metabolic reprogramming also boosts responsiveness to PD-1 blockade, suggesting a potential strategy to improve cancer immunotherapy.

10 Dec 2025

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators.

9 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

AI tools can ease documentation burden and reduce physician burnout

Artificial intelligence (AI) tools designed to automatically document patient visits show promise in reducing the time physicians spend on paperwork and may improve their work experience, according to a new randomized clinical trial conducted at UCLA Health.

26 Nov 2025

Engineered CAR-T cells show promise against glioblastoma in preclinical models

With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer.

20 Nov 2025

Better nurse staffing linked to major drops in physician burnout

The study highlights the impact of organizational factors on physician well-being, emphasizing the need for improved nurse staffing and teamwork in hospitals.

20 Nov 2025

Study uncovers how tumors exploit a molecular signal to exhaust T cells

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them-and how silencing that signal could revive the body's immunity.

17 Nov 2025

Single-cell study reveals how HPV shapes immune landscape in penile cancer

Although penile cancer represents less than 1% of male malignancies, it carries substantial physical and psychological burden, with a five-year survival rate near 50%.

13 Nov 2025

Study links dysautonomia to breathing problems in chronic fatigue patients

Chronic fatigue syndrome leaves patients exhausted and struggling with brain fog - and it typically gets worse after mental or physical exercise, a phenomenon called post-exertional malaise.

10 Nov 2025

Genetic and cellular mechanisms underlying steatotic liver disease

Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), has emerged as the dominant cause of chronic liver disease worldwide, displacing viral hepatitis as the primary aetiology.

10 Nov 2025

New combination treatment overcomes resistance in ER positive breast cancer

In preclinical studies, researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have tested a new combination therapy for hormone-resistant, estrogen receptor-positive (ER+) breast cancer and were able to shrink tumors, reduce the number of cancer stem cells and reprogram the immune environment to be less supportive of cancer growth.

6 Nov 2025

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Urolithin A, a natural postbiotic known to trigger mitophagy, rejuvenated key immune cell functions in healthy middle-aged adults after 28 days. The trial showed a shift toward a youthful, energy-efficient CD8⁺ T-cell profile and enhanced bacterial clearance without inflammatory side effects.

3 Nov 2025

Exhaustion News and Research

What happens to your body during an ultramarathon? New study reveals key metabolic changes

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Engineered herpes virus activates potent immune responses against glioblastoma

AI tools can ease documentation burden and reduce physician burnout

Engineered CAR-T cells show promise against glioblastoma in preclinical models

Better nurse staffing linked to major drops in physician burnout

Study uncovers how tumors exploit a molecular signal to exhaust T cells

Single-cell study reveals how HPV shapes immune landscape in penile cancer

Study links dysautonomia to breathing problems in chronic fatigue patients

Genetic and cellular mechanisms underlying steatotic liver disease

New combination treatment overcomes resistance in ER positive breast cancer

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Ancient DNA uncovers paratyphoid and relapsing fever among Napoleonic troops

Leveraging the power of T cells for more effective and durable cancer immunotherapies

Predictive models identify high-risk liver cancer recurrence

Targeting the glycocalyx may offer a new approach to reduce frailty in older adults

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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