Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Longer caregiving hours tied to worse menopause symptoms in women

Researchers have identified a link between the number of caregiving hours per week a woman performs and menopause symptom burden.

30 Jan 2025

New biomarkers may offer a more sensitive approach for monitoring kidney health

Drug-induced kidney injury, or nephrotoxicity, is a common complication in clinical medicine that happens when drugs damage the kidneys.

6 Jan 2025

CMS introduces new payment model to improve kidney transplant outcomes

A new final rule issued by the Centers for Medicare and Medicaid Services and the U.S. Department of Health and Human Services this week for a mandatory alternative payment model called the Increasing Organ Transplant Access (IOTA) Model aimed to improve the number of life-saving kidney transplants for patients whose kidneys have failed.

2 Dec 2024

The global challenge of weight-related issues in kidney disease

A new nationwide study from Japan spanning a 14 year study period has revealed an increasing trend of overweight and obesity in patients with the incident end-stage kidney disease (ESKD).

6 Nov 2024

3D tumor mapping reveals new insights into cancer biology and treatment

A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells - and the cells of a tumor's surrounding environment - are organized, in 3D, and how that organization changes when a tumor spreads to other organs.

1 Nov 2024

Urine transcriptomics: A new frontier for non-invasive genitourinary disease detection

Researchers explore the potential diagnostic utility of transcriptomic and metabolic signals in the genitourinary system.

29 Oct 2024

NIH grants $2.6 million to explore the effects of high blood-pressure drugs in CKD patients

The National Institutes of Health awarded a four-year, $2.6 million grant to researchers at Case Western Reserve University to study how high blood-pressure drugs affect patients with chronic kidney disease (CKD).

28 Oct 2024

Clinical trial highlights efficacy of imlifidase for kidney transplant recipients

For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX) - a procedure that removes antibodies from the plasma portion of the blood.

27 Oct 2024

Phase 3 trial assesses clazakizumab in kidney transplant recipients with caAMR

Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal antibody that targets the inflammatory cytokine interleukin-6 (IL-6), stabilized kidney transplant recipients' kidney function in a phase 2 trial.

27 Oct 2024

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis.

27 Oct 2024

Novel multi-biomarker approach enhances chronic kidney disease risk assessment

Prior efforts to identify novel kidney biomarkers as risk factors for chronic kidney disease (CKD) progression have typically evaluated proteins individually, which limits their prognostic power.

26 Oct 2024

New trial shows felzartamab reduces proteinuria in IgA nephropathy patients

IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their surface.

26 Oct 2024

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients' age.

26 Oct 2024

Study: GLP-1RA not associated with acute kidney injury risk during anti-cancer treatments

Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA–associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA–associated AKI among patients on anti-cancer drugs is unclear.

26 Oct 2024