Pulmonary Fibrosis News and Research

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Study reveals pathways behind organ damage in severe COVID-19

New research published in the journal Proceedings of the National Academy of Sciences sheds light on the pathways that drive organ damage and death in severe COVID-19 and helps explain why survivors of the disease can experience long-term complications.

2 Dec 2024

Calluna Pharma successfully completes Phase 1 clinical study of CAL101, a first-in-class therapeutic for fibrotic and fibro-inflammatory indications

Calluna Pharma AS (Calluna), a clinical stage biotechnology company pioneering first-in-class antibodies to treat inflammatory and fibrotic diseases, today announced the completion of Phase 1 clinical study for CAL101, Calluna’s lead product candidate.

23 Oct 2024

Boston University and GSK collaborate to tackle pulmonary fibrosis

Researchers from the Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center (BMC) have announced a new collaboration with the global biopharma company GSK to advance innovative research focused on developing cutting-edge models to study and treat lung diseases like pulmonary fibrosis.

17 Oct 2024

Anti-fibrotic drug shows promise in breast cancer

The most common breast cancer is HER2-negative, so called because it has low amounts of one of the proteins that contribute to tumor cell growth, HER2. Despite this common trait, the development of HER2-negative cancers varies among patients, so one goal is to be able to classify tumors in more detail and thus determine the best treatment for each case.

20 Sep 2024

New study offers hope for extending ovarian healthspan and function

A woman's ovaries are like a factory where eggs grow and produce hormones that regulate everything from menstruation and pregnancy to bone density and mood.

17 Sep 2024

Newcells Biotech launches high-content and high-throughput imaging suite to advance pre-clinical drug development programmes

Newcells Biotech (“Newcells”), a leading drug discovery partner specialising in the development of in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced the launch of its imaging suite and advanced lung Fibroblast-to-Myofibroblast Transition (FMT) assay.

From Newcells Biotech 17 Sep 2024

Shorter leukocyte telomere length and greater LTL attrition tied to cystic fibrosis severity

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 16 on August 29, 2024, entitled, "Leukocyte telomere length and attrition in association with disease severity in cystic fibrosis patients."

12 Sep 2024

Immune cells prevent the lungs' protective barrier from healing after viral infections

Investigators involved in a multicenter study co-led by Cedars-Sinai discovered a pathway by which immune cells prevent the lungs' protective barrier from healing after viral infections like COVID-19.

4 Sep 2024

Understanding the mechanisms of cardiac fibrosis

The article explores the role of the m6A reader YTHDF1 in cardiac fibrosis, a condition characterized by the excessive accumulation of extracellular matrix proteins, leading to the stiffening of the heart and impaired function. Cardiac fibrosis is a common pathological process in various cardiovascular diseases, including hypertension, myocardial infarction, and heart failure.

29 Aug 2024

Novel drug-carrying molecule slips past the lung's natural defenses to cure disease

A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter Lab at the University of Virginia School of Engineering and Applied Science.

22 Aug 2024

New ultrasound-based tool offers precise measurement of lung diseases

Researchers have established a suite of parameters that can be determined using ultrasound to quantitatively measure different physical characteristics of the lung.

13 Aug 2024

Insilico Medicine unveils Science42:DORA to streamline academic writing and research

Writing research papers is critical for disseminating scientific findings, but it does come with efficiency burdens, particularly for early-career researchers and non-native English speakers.

28 Jul 2024

Cordyceps sinensis shown to alleviate idiopathic pulmonary fibrosis in mice

A recent study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

25 Jul 2024

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval.

25 Jul 2024

Proteomic signatures enhance risk prediction for both common and rare diseases

Researchers have developed sparse prediction models combining plasma proteins and clinical data to predict the 10-year risk of 218 diseases. The study, involving over 41,000 participants, highlights the enhanced predictive power of proteomic signatures.

24 Jul 2024

Research shows the ability of proteins to predict onset of many diverse diseases

Research on thousands of proteins measured from a drop of blood demonstrates the ability of proteins to predict the onset of many diverse diseases.

22 Jul 2024

Cystic fibrosis drug reduces hyper-inflammation in COVID-19 pneumonia patients

A drug commonly used to treat cystic fibrosis improved outcomes for patients with severe COVID-19 pneumonia and could be used to treat other respiratory infections, according to clinical trial results from researchers at UCL, UCLH and the Francis Crick Institute.

18 Jul 2024

Senolytic drugs are not a "one-size-fits-all" remedy and may benefit some older women

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a "one-size-fits-all" remedy, Mayo Clinic researchers have found.

2 Jul 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Open-ILD: Pioneering stem cell research to combat interstitial lung disease

Imagine a world where breathing is a luxury and a cough marks the sound of an inner battle. Interstitial Lung Disease (ILD), a condition characterised by inflammation and fibrosis, is a major cause of severe respiratory illness and can occur in children.

13 Jun 2024