in vivo News and Research

RSS

Engineered cartilage grafts improve surgery for narrowed child airways

A study led by researchers at Children's Hospital of Philadelphia (CHOP) demonstrated a new method of using decellularized cartilage with patient-specific cells to help enlarge the pediatric airways narrowed as a result of severe subglottic stenosis.

17 Jun 2026

Family genetics study reveals clues to longer healthspan

Understanding why some people stay healthy without developing disease until late in life (have an increased healthspan), whereas others become infirm at a much younger age has important implications for the health of today's ageing population.

15 Jun 2026

Bionic cooling skin accelerates healing and combats wound infections

As the global burden of infected wounds continues to rise-with over 300 million surgeries performed annually and postoperative infections affecting 5–20% of patients-conventional wound dressings face a critical limitation: no single product has successfully integrated protective function, wearing comfort, and efficient antibacterial activity.

15 Jun 2026

Gut microbes control liver genes by flipping DNA switches

A local research study led by scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) has uncovered how the gut microbiome can influence gene activity in the liver by acting on short stretches of regulatory DNA that function like molecular "switches".

15 Jun 2026

Synthetic cooling agents in e-cigarettes link to abnormal heartbeats

Synthetic cooling ingredients added to e-cigarettes caused abnormal heartbeats (arrhythmias) and increased cardiovascular risk measures in mice and lab-grown human heart cells, according to new independent research published today in Circulation: Arrhythmia and Electrophysiology, a peer-reviewed journal of the American Heart Association.

15 Jun 2026

Phase 3 study of in vivo CRISPR therapy for hereditary angioedema successfully completed

Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first-ever Phase 3 study of an in vivo CRISPR therapy.

13 Jun 2026

Injectable wireless device offers new approach to control nerve activity

Researchers from NYU Abu Dhabi, in collaboration with Cleveland Clinic Abu Dhabi, have developed a tiny, injectable medical device that introduces a new approach to treating chronic pain and movement disorders by controlling nerve activity without the need for surgery, batteries, or wires, offering a simpler and less invasive way to treat neurological conditions.

12 Jun 2026

New stretchable bioelectronics advance wearable and implantable health monitoring

Wearable and implantable biosensors have the potential to revolutionize health care by diagnosing, monitoring, and even treating a wide range of health conditions.

11 Jun 2026

New treatment platform delivers full-length mRNA for Duchenne muscular dystrophy

A new treatment platform developed by researchers at The University of Texas MD Anderson Cancer Center was able to deliver messenger RNA (mRNA) of the full-length DMD gene into preclinical models of Duchenne muscular dystrophy, successfully restoring the production of an important muscle protein, dystrophin, and dramatically improving muscle strength, endurance and function in vivo.

11 Jun 2026

Scientists discover new intracellular immune defense against infections

When we think of the immune system, most people imagine white blood cells putting up a fight against invading germs within our bloodstream.

4 Jun 2026

New PET imaging approach quantifies synaptic pathology in multiple sclerosis

A new PET imaging approach that measures synaptic density in the spinal cord provides a quantitative way to assess the brain's functional wiring in patients with multiple sclerosis.

2 Jun 2026

New blood test tracks real time gene expression inside living brain tissue

Cell function is determined by how DNA is expressed into proteins. That process includes two main steps - transcription, when messenger RNA (mRNA) makes copies of active genes, and translation, when mRNA guides protein assembly.

2 Jun 2026

Hypoxia-gated AAV enables targeted treatment for advanced NSCLC

Adeno‑associated virus (AAV) vectors offer safety and durable expression but lack tumor specificity. This hypothesis proposes an NSCLC‑directed, hypoxia‑responsive AAV platform that integrates MGS4 peptide‑guided capsid targeting with dual hypoxia‑responsive element (HRE)‑gated promoters driving Q‑CXCL9‑Fc (chemokine) and miR‑30‑based shRNA against mesothelin (MSLN).

1 Jun 2026

The growing role of NIR-II imaging in preclinical research

NIR-II imaging has many advantages for preclinincal research as it supports deeper visualization with lower scattering and autofluorescence.

From Scintica Instrumentation Inc. 29 May 2026

AI maps how brain fluids move to clear waste

MR-AIV uses physics-informed AI and DCE-MRI scans to infer 3D brain-wide fluid movement in mice without direct flow measurements. The method distinguished slow diffusion-dominated transport from faster advective flow and estimated pressure and permeability patterns linked to brain waste clearance.

28 May 2026

Traditional medicinal plant extract shows promising anti-skin aging effects

Announcing a new publication for Acta Materia Medica journal. Vicatia thibetica de Boiss (V. thibetica), a traditional medicinal and edible plant used by the Bai ethnic group in China, is known for its effects in tonifying qi, nourishing the blood, dispelling dampness, and relieving itching.

27 May 2026

Artificial intelligence reveals hidden fluid flow patterns in sleeping brains

When a person goes into deep sleep, waterlike fluid circulates around the brain, washing away metabolic waste that is linked to diseases such as Alzheimer's.

27 May 2026

Degrading mutant KRAS protein induces greater lung cancer regression

KRAS is one of the oncogenes most frequently altered in cancer, mutated in approximately one-third of lung adenocarcinomas.

27 May 2026

How the right diet could support the gut bacteria that matter most

This review examines how gut keystone bacteria shape microbiome stability, disease risk, and responses to diet. It highlights why better identification methods, experimental validation, and precision diet-probiotic strategies are needed to restore gut homeostasis.

26 May 2026

One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial

A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.

26 May 2026