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Combination therapy found to be effective against treatment-resistant hepatocellular carcinoma

A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital.

30 Nov 2020

Antimicrobial found in soaps worsens fatty liver disease in mice

University of California San Diego School of Medicine researchers found evidence that triclosan -- an antimicrobial found in many soaps and other household items -- worsens fatty liver disease in mice fed a high-fat diet.

23 Nov 2020

Study shows new route for treating myocardial infarction

When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart's ventricular chambers (endocardium). Novel

19 Nov 2020

Scientists identify previously unknown mechanism that drives tumor spread

Any given tumor is composed of a multitude of cell types that can each look or behave differently from its neighbors.

19 Nov 2020

Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

A new study describes two promising small molecules that inhibit a host cell factor, called nucleotide binding oligomerization domain-containing protein 2 (NOD2), that inhibits the replication and spread of many arboviruses. This could lead to the development of broad-spectrum antivirals. The study's findings have been published on the preprint server bioRxiv*.

10 Nov 2020

Preeclampsia-related placental gene expression may be associated with vitamin D status

According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies. It can cause serious, sometimes fatal, complications in the mother and child.

10 Nov 2020

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments.

6 Nov 2020

High Throughput Identification and Quantification of Breast Cancer With NMR-Based Metabolomics

Breast cancer is the leading cause of cancer-related death among the female population globally, despite the ever-growing technology of early detection.

From Bruker BioSpin Division 30 Oct 2020

Novel mechanism increases arterial diameter, allows increased inflow

Upon a heart infarct or stroke, rapid restoration of blood flow, and oxygen delivery to the hypoperfused regions is of eminent importance to prevent further damage to the heart or brain. Arterial diameter is a critical determinant of blood flow conductance.

28 Oct 2020

Scripps Research scientists uncover potential new strategy for treating eye diseases

Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness.

27 Oct 2020

Advancements in research on cancer signal transduction and treatment

Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration.

27 Oct 2020

Novel machine learning algorithm helps find drug binding sites

Scientists from the iMolecule group at Skoltech Center for Computational and Data-Intensive Science and Engineering developed BiteNet, a machine learning algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins.

27 Oct 2020

Happiness neurotransmitter serotonin plays role in evolutionary expansion of the neocortex

During human evolution, the size of the brain increased, especially in a particular part called the neocortex.

23 Oct 2020

New therapeutic approach for treating patients with compromised immune systems

A young woman who had been hospitalized for three months straight due to debilitating, recurrent infections with no apparent underlying cause was finally able to go home thanks to a Massachusetts General Hospital (MGH) team who put their heads together, discovered a root of the problem, and developed a novel treatment strategy just for her.

23 Oct 2020

Researchers assess molecular basis of SARS-CoV-2 severity and poor outcomes in lung disease

A recent study published on the preprint server bioRxiv in October 2020 shows that in patients with chronic lung disease, the pattern of gene expression in the different types of cell changes such that the lung epithelium is prepared to tackle SARS-CoV-2 infection. Also, the altered gene programs have an impact on the immune response.

22 Oct 2020

New diagnostic method may allow for real-time detection of cancer growth patterns

Using a 2 ml blood sample from 100 gastric cancer patients, researchers succeeded in identifying cancer cells circulating in the bloodstream and trace them back to their origin tumor by detecting an overexpression of fibroblast growth factor receptor (FGFR2) in both the cancer cells and the tumor.

21 Oct 2020

New tool can provide non-invasive decision support for NSCLC treatment

Personalized treatment options for patients with lung cancer have come a long way in the past two decades.

16 Oct 2020

Small molecule restores normal heart development in animal model with rare genetic disorder

A research team at the Greenwood Genetic Center has successfully used small molecules to restore normal heart and valve development in an animal model for Mucolipidosis II (ML II), a rare genetic disorder. Progressive heart disease is commonly associated with ML II.

15 Oct 2020

Study provides new insight into unknown effects of factors that regulate blood vessel formation

A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation.

14 Oct 2020

SARS-CoV-2 spike protein may induce analgesia

A recent study published in the journal Pain in October 2020 adds another piece to the puzzle, showing that the virus is capable of dulling pain pathways. This may contribute to its early and extensive spread.

7 Oct 2020

Growth Factor News and Research

Combination therapy found to be effective against treatment-resistant hepatocellular carcinoma

Antimicrobial found in soaps worsens fatty liver disease in mice

Study shows new route for treating myocardial infarction

Scientists identify previously unknown mechanism that drives tumor spread

Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

Preeclampsia-related placental gene expression may be associated with vitamin D status

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

High Throughput Identification and Quantification of Breast Cancer With NMR-Based Metabolomics

Novel mechanism increases arterial diameter, allows increased inflow

Scripps Research scientists uncover potential new strategy for treating eye diseases

Advancements in research on cancer signal transduction and treatment

Novel machine learning algorithm helps find drug binding sites

Happiness neurotransmitter serotonin plays role in evolutionary expansion of the neocortex

New therapeutic approach for treating patients with compromised immune systems

Researchers assess molecular basis of SARS-CoV-2 severity and poor outcomes in lung disease

New diagnostic method may allow for real-time detection of cancer growth patterns

New tool can provide non-invasive decision support for NSCLC treatment

Small molecule restores normal heart development in animal model with rare genetic disorder

Study provides new insight into unknown effects of factors that regulate blood vessel formation

SARS-CoV-2 spike protein may induce analgesia

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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