Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Depressed adolescents respond best to psychotherapy and antidepressant medication

A combination of psychotherapy and antidepressant medication appears to be the most effective treatment for adolescents with major depressive disorder - more than medication alone or psychotherapy alone, according to results from a major clinical trial funded by the National Institutes of Health's National Institute of Mental Health (NIMH).

2 Oct 2007

Genetic test announced for suicidal ideation in patients using antidepressant drugs

NeuroMark, a Boulder, Colorado company, announced today the immediate availability of a genetic test to identify people at risk of suicidal ideation - thoughts of committing suicide - when prescribed an antidepressant drug.

27 Sep 2007

Potential new therapeutic target for obesity

A hormone system linked to reducing food consumption appears to do so by increasing stress-related behaviors, according to a new study.

25 Sep 2007

Women more depressed and men more impulsive with reduced serotonin functioning

Women and men appear to respond differently to the same biochemical manipulation.

18 Sep 2007

Seroquel XR tablets approved in Netherlands for the treatment of schizophrenia

AstraZeneca today announced the Netherlands regulatory authority MEB (Medicines Evaluation Board) has approved Seroquel XR (quetiapine fumarate) Extended-Release Tablets, a once-daily medicine for the treatment of schizophrenia in adult patients.

29 Aug 2007

Depression over-diagnosed and many people just blue

An Australian psychiatrist has accused the medical profession of over-diagnosing depression, and says thousands of people are wrongly being prescribed drugs to treat it.

20 Aug 2007

Brain imaging reveals breakdown of normal emotional processing

Brain imaging has revealed a breakdown in normal patterns of emotional processing that impairs the ability of people with clinical depression to suppress negative emotional states.

17 Aug 2007

Emotional brain circuits and depression

In what may be the first study to use brain imaging to look at the neural circuits involved in emotional control in patients with depression, researchers at the University of Wisconsin-Madison have found that brains of people with clinical depression react very differently than those of healthy people when trying to cope with negative situations.

16 Aug 2007

Cerebral blood flow provides clues to treating depression

The usefulness of established molecular imaging/nuclear medicine approaches in identifying the hows and whys of brain dysfunction and its potential in providing immediately useful information in treating depression are emphasized in a study in the August Journal of Nuclear Medicine.

9 Aug 2007

Kids who prefer evenings are more likely to exhibit antisocial behavior

A propensity for activities in the evening rather than in the morning may offer clues to behavioral problems in early adolescence, according to psychologists who have found that kids who prefer evenings are more likely to exhibit antisocial behavior, rule-breaking, and attention problems.

11 Jul 2007

Five distinct subtypes of alcoholism identified

Analyses of a national sample of individuals with alcohol dependence (alcoholism) reveal five distinct subtypes of the disease, according to a new study by scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).

29 Jun 2007

Barr announces tentative approval for generic version of Effexor tablets

Barr Pharmaceuticals, Inc. has announced that its subsidiary PLIVA has received tentative approval from the U.S. Food and Drug Administration (FDA) for its generic version of Wyeth Pharmaceuticals Inc.'s Effexor (Venlafaxine Hydrochloride) Tablets, 25mg, 37.5mg, 50mg, 75mg and 100mg.

27 Jun 2007

Genetic variations may help explain why some men with depression develop suicidal thoughts

Although most patients with depression respond favorably to antidepressant medications, a very small subgroup may experience worse symptoms after beginning treatment, according to background information in the article.

5 Jun 2007

Urgent need for countries to provide a network of community mental health services

For the first time, WHO invited people living with mental disorders to attend the Forum, sending a message to countries that it is important to give a voice to this excluded group to claim their rights and secure their participation in society.

3 Jun 2007

Adding medication improves recovery for elderly with depression

Adding a medication to a standard treatment regimen for major depressive disorder in the elderly improves chances of recovery in those who do not adequately respond to the first-course therapy or who relapse from it, finds a University of Pittsburgh School of Medicine study published in the June issue of the American Journal of Psychiatry, the official journal of the American Psychiatric Association.

3 Jun 2007

New mothers often not asked about depression

The majority of doctors in North Carolina do not probe for signs of postpartum depression in new mothers, according to a survey conducted by researchers at the University of North Carolina at Chapel Hill.

1 Jun 2007

Efficacy and safety of Aripiprazole as adjunctive therapy in major depressive disorder

In adults with major depressive disorder, adding aripiprazole to antidepressant therapy (ADT) resulted in significant improvement in the primary endpoint, the Montgomery-Asberg Depression Rating Scale (MADRS) Total Score.

24 May 2007

FDA wants new warnings on antidepressant medications

The U.S. Food and Drug Administration (FDA) has proposed that makers of all antidepressant medications update the existing black box warning on their products' labeling to include warnings about increased risks of suicidal thinking and behavior, known as suicidality, in young adults ages 18 to 24 during initial treatment (generally the first one to two months).

4 May 2007

FDA - all antidepressants need new warning labels

The Food and Drug Administration (FDA) in the United States wants the manufacturers of antidepressant medications to change the labels on their products.

3 May 2007

Pregnant U.S. women commonly smoke

While pregnancy may be considered an effective motivator for smoking cessation, results of a new study by researchers at the Mailman School of Public Health indicate that pregnant U.S. women commonly smoke, placing themselves and their unborn children at risk for health and developmental complications.

25 Apr 2007