Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Human microbiome metabolites enhance colon injury by enterohemorrhagic E. coli, study shows

It remains mysterious why humans get infected by some bacterial or viral pathogens relatively easily while animals that have very similar tissues and immune functions do not.

20 Mar 2019

Age-related changes to gut microbiome have adverse impact on vascular health, study shows

Why do blood vessels naturally stiffen and degrade as we age, boosting cardiovascular disease risk? New University of Colorado Boulder research has identified a surprising new culprit--and it lives in your gut.

20 Mar 2019

Researchers measure brain metabolite levels in people with mild memory problems

Using strong and targeted but noninvasive magnets at specific sites in the brains of people with and without mild learning and memory problems, Johns Hopkins researchers report they were able to detect differences in the concentrations of brain chemicals that transmit messages between neurons.

20 Mar 2019

Preliminary estimation of contaminants and aromatic substances in diapers

The report "Sécurité des couches pour bébé", published by the French Agency for Food, Environmental and Occupational Health & Safety, deals with hazardous substances in disposable panty diapers.

7 Mar 2019

Research reveals how metabolites can be used to inhibit epigenetic mechanisms and treat MS

Understanding and mitigating the role of epigenetics (environmental influences that trigger changes in gene expression) in disease development is a major goal of researchers.

28 Feb 2019

Researchers find new precise and accurate biomarker of cyanide exposure

Cyanide exposure can happen occupationally or in low levels from inhaling cigarette smoke -- or from being poisoned by someone out to get you.

28 Feb 2019

Researchers pinpoint a set of enzymes involved in colon cancer growth

University of Massachusetts Amherst food science researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer.

26 Feb 2019

Children from homes with flame-retardant sofa have high SVOC concentration in their blood

Children living in homes with all vinyl flooring or flame-retardant chemicals in the sofa have significantly higher concentrations of potentially harmful semi-volatile organic compounds in their blood or urine than children from homes where these materials are not present, according to a new Duke University-led study.

18 Feb 2019

Discovery of weakness in a rare cancer could be exploited with drugs

Cancer cells are, in some respects, impressive: They can grow relentlessly, sidestep the aging process by becoming immortal, and evade the immune system's persistent attacks. But in the process of acquiring such superpowers, the cells must occasionally relinquish other, more mundane skills--including the ability to produce certain nutrients.

15 Feb 2019

New 'WormJam model' could provide valuable insights into human aging

What can worms tell us about human aging? A lot more than you'd think; as research led by the Babraham Institute but involving researchers from multiple disciplines drawn together from across the world has shown.

7 Feb 2019

Hibernation spurts of hamsters hold clues to better treatments for Alzheimer's disease

Syrian hamsters are golden-haired rodents often kept as house pets. Cold and darkness can cause the animals to hibernate for 3-4 days at a time, interspersed with short periods of activity.

7 Feb 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Yeast model may pave way for development of novel therapies for metabolic disorders

There are hundreds of metabolic disorders -- including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria.

17 Jan 2019

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Cancer is a multidisciplinary disease, with different mutations leading to different prognoses and treatment necessities. Among the most important mutation targets in cancers, affecting more than 50% of all cancer cases, is TP53.

14 Jan 2019

Microbial metabolite from pomegranates can reduce and protect against IBD

Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease.

10 Jan 2019

Metabolite from berries and pomegranates can mitigate inflammatory bowel disease

Millions of people suffer from inflammatory bowel disease worldwide, either in the form of ulcerative colitis or Crohn's disease, and few effective long-term treatments are available. Chronic intestinal inflammation is a hallmark of IBD.

9 Jan 2019

Study elucidates how essential amino acid in humans acts as growth signal for cells

A recent study from the Laxman lab elucidates how a small metabolite and amino acid, methionine, acts as a growth signal for cells, by setting into motion a metabolic program for cell proliferation.

7 Jan 2019

Egg metabolites in blood linked to reduced risk of type 2 diabetes

Consumption of one egg every day seems to associate with a blood metabolite profile that is related to a lower risk of type 2 diabetes, a new study conducted in the University of Eastern Finland shows.

3 Jan 2019

Sleeping sickness parasite exhibits metabolic flexibility and adaptability

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of the University of Dundee in the UK, and colleagues.

28 Dec 2018

Reducing alcohol use could help quit daily smoking habit

If quitting smoking is one of your New Year's resolutions, you might want to consider cutting back on your drinking, too.

28 Dec 2018

Metabolite News and Research

Further Reading

Human microbiome metabolites enhance colon injury by enterohemorrhagic E. coli, study shows

Age-related changes to gut microbiome have adverse impact on vascular health, study shows

Researchers measure brain metabolite levels in people with mild memory problems

Preliminary estimation of contaminants and aromatic substances in diapers

Research reveals how metabolites can be used to inhibit epigenetic mechanisms and treat MS

Researchers find new precise and accurate biomarker of cyanide exposure

Researchers pinpoint a set of enzymes involved in colon cancer growth

Children from homes with flame-retardant sofa have high SVOC concentration in their blood

Discovery of weakness in a rare cancer could be exploited with drugs

New 'WormJam model' could provide valuable insights into human aging

Hibernation spurts of hamsters hold clues to better treatments for Alzheimer's disease

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Yeast model may pave way for development of novel therapies for metabolic disorders

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Microbial metabolite from pomegranates can reduce and protect against IBD

Metabolite from berries and pomegranates can mitigate inflammatory bowel disease

Study elucidates how essential amino acid in humans acts as growth signal for cells

Egg metabolites in blood linked to reduced risk of type 2 diabetes

Sleeping sickness parasite exhibits metabolic flexibility and adaptability

Reducing alcohol use could help quit daily smoking habit

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