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Titrzepatide reduces risk of death or worsening heart failure for patients with obesity-related heart failure

Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with heart failure, preserved heart pump function and obesity, new research from UVA Health reveals.

21 Nov 2024

Nanoparticle coating enhances cancer drug delivery and reduces side effects

A spoonful of sugar might actually help the medicine go down, according to recent research from the University of Mississippi. And it could reduce the harmful side effects of cancer treatment.

21 Nov 2024

Preterm birth linked to increased mortality risk across decades

According to a new study from researchers at Wake Forest University School of Medicine and The Hospital for Sick Children (SickKids) in Toronto, being born preterm is associated with an increased risk of death from birth until the third and fourth decades of life.

21 Nov 2024

Pcdh8 gene suppression critical for zebrafish notochord formation

Can a single protein-encoding gene determine whether a vertebrate embryo develops normally? Yes, according to Osaka Metropolitan University researchers, who found that suppression of Pcdh8 is essential for the notochord to elongate properly in zebrafish.

21 Nov 2024

Electrical stimulation of vagus nerve could combat inflammatory bowel disease

Researchers at Duke University School of Medicine have found that tapping into the nervous system could help reduce the gut inflammation that drives inflammatory bowel disease (IBD).

20 Nov 2024

Jaw muscle size linked to sarcopenia risk in older adults

As populations age, the prevalence of sarcopenia - a progressive loss of muscle mass and function - has become an increasingly urgent public health concern. Sarcopenia increases the risk of falls and frailty, reduces the quality of life for older adults, and heightens the likelihood of requiring long-term care. Preventing sarcopenia is, therefore, crucial for alleviating this healthcare burden.

20 Nov 2024

Novel combination of surgery and embolization reduces recurrence of subdural hematomas

A novel combination of surgery and embolization used to treat subdural hematomas, bleeding between the brain and its protective membrane due to trauma, reduces the risk of follow-up surgeries, according to researchers at Weill Cornell Medicine and University at Buffalo.

20 Nov 2024

High NHS staff turnover rates associated with rise in patient mortality

More than 4,000 people could be dying per year because of high turnover rates of nurses and doctors in NHS hospitals, according to new research from the University of Surrey.

20 Nov 2024

Decoding the genetic roots of stroke and heart attack

In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.

20 Nov 2024

Researchers develop low cost, scalable methodology for early dementia detection

A new study by researchers from Regenstrief Institute, Indiana University and Purdue University presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia.

20 Nov 2024

EZH2 enzyme drives aggressive tumor growth in treatment-resistant prostate cancer

An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study by scientists at Weill Cornell Medicine.

20 Nov 2024

New collaboration aims to improve mental health services for primary care patients

Northwestern Medicine, West Health, and the Meadows Mental Health Policy Institute have announced a new collaboration that will make accessing care to evidence-based mental health services faster and easier for primary care patients across Northwestern Medicine.

20 Nov 2024

USC researchers receive $6 million to advance dry AMD treatment

The California Institute for Regenerative Medicine (CIRM), the state's stem cell agency, has awarded a two-year, $6 million grant to a team at the USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics and the USC Roski Eye Institute advancing a new treatment for one of the leading causes of blindness in older adults.

20 Nov 2024

Landmark study highlights growing pediatric IBD rates across the U.S.

A groundbreaking study published today in Gastroenterology provides the most comprehensive assessment to date of pediatric inflammatory bowel disease (IBD) prevalence in the United States.

20 Nov 2024

CRISPR-based therapy shown to be safe, effective for people with transthyretin amyloidosis

A new type of therapy that 'edits' a gene in patients with a rare heart condition has been shown to be safe and effective, according to research from UCL and the Royal Free Hospital.

20 Nov 2024

Researchers unlock cell density as a tool for building synthetic tissues

Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs. In a new paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist Matt Thomson characterize the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space.

20 Nov 2024

Study links GERD to increased cardiovascular risk factors

A recent study published in the Journal of Translational Internal Medicine (https://doi.org/10.1515/jtim-2024-0017) reveals significant insights into the broader impact of gastroesophageal reflux disease (GERD) on cardiovascular health.

20 Nov 2024

Researchers uncover hidden roles of accessory genes in SARS-CoV-2

Viruses are lean, mean, infection machines. Their genomes are tiny, usually limited to a handful of absolutely essential genes, and they shed extra genomic deadweight extremely fast.

20 Nov 2024

New approach to stabilize RSV protein could lead to better vaccines

In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) trigger mild cold-like symptoms. But in infants and seniors, these viruses can cause severe pneumonia and even death.

20 Nov 2024

Study identifies DNA collisions driving genetic changes in cancer

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

20 Nov 2024