B Cell News and Research

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Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

30 Mar 2023

New research may upend long-held scientific dogma about short telomeres and cancer risk

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

30 Mar 2023

AI outperforms the leading tools in predicting enzyme function

A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood.

30 Mar 2023

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

A study published in Cell Reports Medicine describes that COVID-19 vaccines induce strong T cell response in blood cancer patients, irrespective of antibody response and B cell numbers.

30 Mar 2023

Do two or more mRNA vaccine doses provide additional protection in patients with prior COVID-19 infection?

Researchers conducted a retrospective cohort study among vaccinated and unvaccinated COVID-19 patients between December 16, 2020, and March 15, 2022, in the USA.

30 Mar 2023

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Researchers identified an interleukin 6 dependent alternative pathway as a therapeutic strategy against coronavirus disease 2019.

30 Mar 2023

Study finds recent shingles infection increases the risk of myocardial infarction

Researchers assessed myocardial infarction (MI) risk after zoster infection.

30 Mar 2023

Study finds that current antiviral drugs retain efficacy against newly emerged Omicron subvariants

Researchers assessed the efficacy of antiviral medications against novel Omicron subvariants.

30 Mar 2023

New review examines link between HDLC and different types of cancer

Researchers summarized studies on the association between high-density lipoprotein cholesterol and different types of cancer

29 Mar 2023

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Senescence and extracellular vesicles: novel partners in vascular amyloidosis."

29 Mar 2023

Shape of the heart determines your risk for two common heart conditions

Curious to know if you're at risk for two common heart conditions? Your doctor may want to check the shape of your heart.

29 Mar 2023

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20–30% patients with cancer respond to ICI treatment.

29 Mar 2023

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

In recent years, innovative cancer drugs that target specific molecular drivers of the disease have been embraced as the treatment of choice for many types of cancer.

29 Mar 2023

Study paves the way for wider applications of cell reprogramming in medicine

Sanford Burnham Prebys researchers have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues.

29 Mar 2023

Scientists uncover novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health

A team of researchers from Ohio University's Heritage College of Osteopathic Medicine recently discovered a novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health.

29 Mar 2023

Study investigates how loss of angulin-1/LSR affects the malignancy of lung adenocarcinoma

A new research paper was published in Oncotarget's Volume 14 on March 24, 2023, entitled, "Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells."

29 Mar 2023

Johns Hopkins Medicine surgeons to receive $21.4 million to advance xenotransplantation research

As part of the worldwide effort to facilitate a research and clinical pathway toward successful xenotransplantation - the transplantation of living cells, tissues and organs from one species to another - two Johns Hopkins Medicine surgeons, Kazuhiko Yamada, M.D., Ph.D., and Andrew Cameron, M.D., Ph.D., will receive a total of $21.4 million in funding over the next two years under two sponsored research agreements with biotechnology company United Therapeutics Corporation.

29 Mar 2023

Study finds correlations between how and which organ systems are affected in individuals with new epileptic disorder

A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein.

29 Mar 2023

Hemex Health awarded $3 million grant to advance commercialization of Gazelle Hb Variant Test for the U.S. market

Hemex Health, a medical diagnostic device company focused on expanding healthcare access to underrepresented patient populations, announced it has been awarded a 3-year, $3 million grant from the National Heart, Lung, and Blood Institute.

29 Mar 2023

B Cell News and Research

Riboswitch may be the key to advance gene therapy, regenerative medicine

New type of nanoparticle can deliver messenger RNA encoding useful proteins to the lungs

New research may upend long-held scientific dogma about short telomeres and cancer risk

AI outperforms the leading tools in predicting enzyme function

The breadth of immune responses following COVID-19 vaccination in hematology patients with diseases and treatments impacting B cell immunity

Do two or more mRNA vaccine doses provide additional protection in patients with prior COVID-19 infection?

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Study finds recent shingles infection increases the risk of myocardial infarction

Study finds that current antiviral drugs retain efficacy against newly emerged Omicron subvariants

New review examines link between HDLC and different types of cancer

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

Shape of the heart determines your risk for two common heart conditions

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

Study paves the way for wider applications of cell reprogramming in medicine

Scientists uncover novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health

Study investigates how loss of angulin-1/LSR affects the malignancy of lung adenocarcinoma

Johns Hopkins Medicine surgeons to receive $21.4 million to advance xenotransplantation research

Study finds correlations between how and which organ systems are affected in individuals with new epileptic disorder

Hemex Health awarded $3 million grant to advance commercialization of Gazelle Hb Variant Test for the U.S. market

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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