Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Senescence and extracellular vesicles: novel partners in vascular amyloidosis."

In their editorial, researchers Meredith Whitehead, Marco Antonazzi and Catherine M. Shanahan from King's College London discussed amyloidosis - a prevalent age-associated pathology caused by the accumulation of fibrous, insoluble protein fibrils in tissues. The most common human amyloid is aortic medial amyloid (AMA), caused by aggregation of a 50-amino acid peptide called medin, which is cleaved by an unknown mechanism from its parent protein, milk fat globulin EGF-factor 8 (MFGE8). Medin is present in the vessel wall of 97% of Caucasians aged over 50- years, yet despite its prevalence in the aging population there is a very limited understanding of the mechanisms driving AMA.

"Despite several forms of amyloidosis, including AMA and Alzheimer's disease (AD), being frequently associated with aging, there has been limited research to date on the effect of cellular 'aging', termed senescence, on amyloidosis."

The novel data presented in the paper by Whitehead et al. provides evidence that vascular smooth muscle cell (VSMC)-derived small extracellular vesicles (sEVs) are key mediators of medin accumulation in the vessel wall. In addition, the authors identify, for the first time, a role for cellular senescence in triggering amyloidosis via changes in sEVs and extracellular matrix (ECM) composition. Thus, this study not only advances our understanding of how AMA is formed but uncovers potential therapeutic targets for mitigating the detrimental effects of amyloidosis on tissue function.

"Further work is now required to understand the relationships between cellular aging pathways, different forms of amyloidosis and potentially other aging pathologies with shared mechanisms, such as vascular calcification, that often occur concomitantly within the aged ECM."