Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Cardiovascular disease risk linked to early brain decline in men

Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier - from their mid 50s to mid 70s - than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry.

26 Nov 2024

Machine learning tool detects early signs of Alzheimer's in mice

Subtle signs of Alzheimer's disease can emerge decades before a diagnosis - often in the form of irregular behaviors that reflect very early stages of brain dysfunction.

26 Nov 2024

Nasal spray shows promise in combating Alzheimer's

A future treatment for Alzheimer disease may involve a nasal spray. Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase (zDHHC) through a nasal-spray drug, they can counteract the cognitive decline and brain damage typical of the disease.

26 Nov 2024

Addressing the challenges of cognitive impairment detection in primary care

Early detection of cognitive impairment is essential for improving patient outcomes, but primary care settings face significant challenges in screening. This special report summarizes key points and gaps in knowledge about methods for detecting cognitive impairment in primary care clinics.

25 Nov 2024

Brain volume loss linked to Alzheimer's treatment may be caused by amyloid plaque removal

A loss of brain volume associated with new immunotherapies for Alzheimer's disease may be caused by the removal of amyloid plaques, rather than the loss of neurons or brain tissue, finds a study led by UCL researchers.

25 Nov 2024

New study offers insights into reliable Alzheimer's diagnosis

A research group at LMU University Hospital has investigated how Alzheimer's disease can be diagnosed more reliably in the future.

25 Nov 2024

Researchers develop new approach to effectively deliver therapeutics into the brain

Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach - demonstrated in mouse models and isolated human brain tissue - to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of neurological and psychiatric diseases.

25 Nov 2024

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging

Prenatal exposure to maternal pro-inflammatory cytokines shapes memory and immune function in offspring, with sex-specific effects emerging over 50 years.

24 Nov 2024

Pioneering protocol sheds light on NMDA receptor distribution in Alzheimer's brains

Researchers from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), who are also part of the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Alicante Institute for Health and Biomedical Research (ISABIAL), have developed a cellular fractionation protocol.

22 Nov 2024

New neuroimaging marker may identify persons at risk of dementia in future clinical trials

A new neuroimaging marker of cerebral small vessel disease is related to general cognition and may serve to identify persons at risk of dementia in future clinical trials, a landmark study has found.

21 Nov 2024

Study links prenatal immune activity to Alzheimer's risk in later life

Findings from a Mass General Brigham-led study that has followed participants since before birth may offer clues about the origins of Alzheimer's disease.

21 Nov 2024

Study links historical education policies to better cognitive outcomes later in life

Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a study led by a Rutgers Health researcher.

21 Nov 2024

Researchers develop low cost, scalable methodology for early dementia detection

A new study by researchers from Regenstrief Institute, Indiana University and Purdue University presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia.

20 Nov 2024

New insights into brain aging and Alzheimer's from non-human primates

A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on October 29, 2024, Volume 16, Issue 20, titled, "Brain aging and Alzheimer's disease, a perspective from non-human primates."

20 Nov 2024

Using earpiece microphones to spot early signs of Alzheimer's

Alzheimer's disease affects more than 50 million people worldwide, often devastating both the individuals who have it and their families and loved ones.

20 Nov 2024

New protein target offers promise for alleviating cognitive decline in Parkinson's disease

A recently published study by researchers at the University of Arizona Health Sciences found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.

19 Nov 2024

Quick finger prick could soon make Alzheimer's testing much more accessible

A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon make Alzheimer's testing much more accessible worldwide.

18 Nov 2024

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR) - long studied primarily for its role in learning and memory - also plays a crucial role in stabilizing brain activity.

15 Nov 2024

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

14 Nov 2024

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Professor Nancy Ip discusses her groundbreaking neuroscience research, focusing on neurotrophic factors and innovative Alzheimer's disease treatment approaches.

13 Nov 2024

Alzheimer's Disease News and Research

Further Reading

Cardiovascular disease risk linked to early brain decline in men

Machine learning tool detects early signs of Alzheimer's in mice

Nasal spray shows promise in combating Alzheimer's

Addressing the challenges of cognitive impairment detection in primary care

Brain volume loss linked to Alzheimer's treatment may be caused by amyloid plaque removal

New study offers insights into reliable Alzheimer's diagnosis

Researchers develop new approach to effectively deliver therapeutics into the brain

From womb to midlife: Prenatal immune disruptions reshape memory and cognitive aging

Pioneering protocol sheds light on NMDA receptor distribution in Alzheimer's brains

New neuroimaging marker may identify persons at risk of dementia in future clinical trials

Study links prenatal immune activity to Alzheimer's risk in later life

Study links historical education policies to better cognitive outcomes later in life

Researchers develop low cost, scalable methodology for early dementia detection

New insights into brain aging and Alzheimer's from non-human primates

Using earpiece microphones to spot early signs of Alzheimer's

New protein target offers promise for alleviating cognitive decline in Parkinson's disease

Quick finger prick could soon make Alzheimer's testing much more accessible

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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