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SYS6006 investigational COVID-19 mRNA vaccine shows promise as fourth dose booster

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 600 million confirmed cases and 6.5 million deaths worldwide.

4 Jul 2023

CRISPR/Cas9-based screening identifies potential therapies for non-alcoholic fatty liver disease

Activation of the NRF2 transcription factor shows promise as a potential treatment approach for non-alcoholic fatty liver disease (NAFLD), a condition associated with oxidative stress and liver damage. By screening FDA-approved drugs, researchers identified six compounds that enhanced NRF2 activity and demonstrated protective effects against oxidative stress and lipid accumulation.

3 Jul 2023

New study uncovers effects of beer compound on cartilage cells in osteoarthritis

Formononetin (FNT), an isoflavonoid present in beer, was investigated for its effects on chondrocytes, the cells responsible for joint health. While low levels of FNT showed no harm and reduced inflammation, excessive exposure promoted catabolic responses, shedding light on the relationship between beer consumption and osteoarthritis risk.

3 Jul 2023

New COVID-19 mRNA vaccine is safe and highly immunogenic as a heterologous booster: Study

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 600 million confirmed cases and 6.5 million deaths worldwide.

3 Jul 2023

COVID-19 severity linked to autoantibodies against blood clotting protein

Study investigates the occurrence of ADAMTS13 antibodies in COVID-19 patients and their association with disease severity and lower ADAMTS13 activity. The findings suggest the need to include ADAMTS13 antibodies in diagnosing and managing SARS-CoV-2 infections.

2 Jul 2023

Towards Zika preparedness: immunogenicity insights from vaccine research

Study assesses the safety and immunogenicity of an inactivated Zika virus vaccine candidate.

30 Jun 2023

Study shows promising prospects for automating 3D-DSRT in drug testing

The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.

29 Jun 2023

UH and CWRU research teams win Collaborative Science Pilot Awards

Three University Hospitals (UH) and Case Western Reserve University School of Medicine research teams recently received Collaborative Science Pilot Awards. The teams each received $50,000, funded by both institutions.

28 Jun 2023

New digital assay can directly measure the presence of HIV in single drop of blood

A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies.

27 Jun 2023

Is there an association between muscle-building supplements and DNA damage in resistance training practitioners?

A recent study investigated whether muscle-building supplements are associated with DNA damage in individuals practicing resistance training.

27 Jun 2023

New research shows antibody cross-reactivity between human and animal coronaviruses

Researchers probed for antibody binding against all seven human coronaviruses (hCoVs).

27 Jun 2023

New study shows promise for diphenyl ditelluride as anti-cancer drug

A new research paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells."

26 Jun 2023

Innovative nanofluidic device detects single proteins at their naturally high concentrations

In the evolving world of precision medicine, the need for methods that can measure biomolecules with supreme accuracy and specificity is paramount. Recognizing this, Associate Professor Yan Xu of the Graduate School of Engineering at Osaka Metropolitan University and his international research team have made a great stride in this direction. They have developed an innovative nanofluidic device capable of capturing single proteins stochastically and detecting them digitally at their naturally high concentrations. This breakthrough could potentially lay the foundation for the future of personalized disease prevention and treatment.

26 Jun 2023

New rapid automated viral plaque detection system enabled by holography and deep learning

In a new paper published in Nature Biomedical Engineering, a team of scientists led by Professor Aydogan Ozcan from the Electrical and Computer Engineering Department at UCLA and an associate director of the California NanoSystems Institute, developed a rapid, stain-free, and automated viral plaque detection system enabled by holography and deep learning.

23 Jun 2023

Assay News and Research

SYS6006 investigational COVID-19 mRNA vaccine shows promise as fourth dose booster

CRISPR/Cas9-based screening identifies potential therapies for non-alcoholic fatty liver disease

New study uncovers effects of beer compound on cartilage cells in osteoarthritis

New COVID-19 mRNA vaccine is safe and highly immunogenic as a heterologous booster: Study

COVID-19 severity linked to autoantibodies against blood clotting protein

Towards Zika preparedness: immunogenicity insights from vaccine research

Study shows promising prospects for automating 3D-DSRT in drug testing

UH and CWRU research teams win Collaborative Science Pilot Awards

New digital assay can directly measure the presence of HIV in single drop of blood

Is there an association between muscle-building supplements and DNA damage in resistance training practitioners?

New research shows antibody cross-reactivity between human and animal coronaviruses

New study shows promise for diphenyl ditelluride as anti-cancer drug

Innovative nanofluidic device detects single proteins at their naturally high concentrations

New rapid automated viral plaque detection system enabled by holography and deep learning

Plant based compound peruvoside may be able to prevent up to 12 medically important viruses

Is there an association between COVID-19 vaccination and changes in ovarian reserve?

New insights into lymphatic cell migration and lymphatic vessel remodeling

New adhesive bandage relies on gold nanoparticles to quickly detect COVID-19 antibodies

PacBio collaborates with Radboudumc to explore genetic causes of rare and genetic diseases

Herbal extracts for mental health: Are they safe for pregnant women?

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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