Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

GVK Biosciences extends GOBIOM license to Biomarker Qualification Group of US FDA

GVK Biosciences (GVK BIO) today announced that it is extending its Clinical Biomarker Database (GOBIOM) license to the Biomarker Qualification Group of the US Food and Drug Administration (US FDA).

5 Feb 2013

Nicotine metabolism inversely linked to addiction severity in teens

Reduced nicotine metabolism is associated with a greater number of cigarettes smoked per day and increased levels of dependence in adolescent smokers, researchers report.

4 Feb 2013

Scientists review damage-control in metabolism

In this week's issue of the prestigious journal Nature Chemical Biology, scientists Carole Linster (University of Luxembourg), Emile Van Schaftingen (Louvain University), and Andrew D. Hanson (University of Florida, Gainesville) review an important, but so far neglected, part of metabolism, namely metabolite damage-control.

31 Jan 2013

FDA accepts Genzyme’s LEMTRADA sBLA for review

Genzyme, a Sanofi Company, announced that the U.S. Food and Drug Administration (FDA) has accepted for review the company's supplemental Biologics License Application (sBLA) file seeking approval of LEMTRADA (alemtuzumab) for the treatment of relapsing multiple sclerosis (RMS).

28 Jan 2013

Lack of Mthfd1l enzyme causes neural tube defects in developing embryos

Researchers at The University of Texas at Austin have discovered that the lack of a critical enzyme in the folic acid metabolic pathway leads to neural tube birth defects in developing embryos.

18 Jan 2013

Acetaminophen may improve postoperative outcomes

Prophylactically administered intravenous acetaminophen could reduce postoperative nausea and vomiting, research suggests.

16 Jan 2013

DNA adducts linked to oral cancer in smokers

Having a high susceptibility to certain types of DNA damage caused by tobacco smoking could significantly increase the risk for oral cancer, show results of a Taiwanese study.

28 Dec 2012

Researchers study response of living cells to artificial protein

One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniques-collectively referred to as synthetic biology-have been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes.

28 Dec 2012

Jagaricin and antifungal drugs: an interview with Prof Christian Hertweck

Most people have already experienced a fungal infection (mycosis) of the outer layer of the skin, athlete’s foot or ringworm. Whereas such infections may be cumbersome and often difficult to cure, usually they are not dangerous. However, in cases where a fungus causes a systemic infection, this is, it infects internal organs such as lungs or brain, the infection may turn into a life-threatening disease. Of course, only pathogenic fungi cause problems and the degree of virulence varies.

18 Dec 2012

Study finds new evidence that vitamin D decreases risk of autism in children

A study just published online in the peer-reviewed journal Dermato-Endocrinology found additional evidence that vitamin D reduces the risk of developing autism.

14 Dec 2012

Study identifies metabolic factors related to bread's beneficial effects on cardiovascular health

According to a study, daily bread consumption, especially wholemeal bread, can prevent cardiovascular disease. The study has been led by the professor Rafael Llorach, Ramon y Cajal researcher from the Department of Nutrition and Bromatology at the Faculty of Pharmacy and from the Food and Nutrition Torribera campus of the University of Barcelona.

29 Nov 2012

Preschool children particularly vulnerable to food-borne toxins

In a sobering study published in the journal Environmental Health, researchers at UC Davis and UCLA measured food-borne toxin exposure in children and adults by pinpointing foods with high levels of toxic compounds and determining how much of these foods were consumed.

14 Nov 2012

TRILOGY-ACS platelet function substudy results revealed

The platelet function substudy of the TRILOGY-ACS trial shows that there is no significant difference between prasugrel and clopidogrel in cardiovascular mortality, myocardial infarction, or stroke outcomes.

12 Nov 2012

Lack of vitamin D2 associated with Alzheimer's

Scientists at London's Kingston University have uncovered evidence that lack of a particular form of vitamin D is associated with Alzheimer's disease.

8 Nov 2012

Washington University, SRI investigators launch Global Metabolomic Initiative

Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people.

7 Nov 2012

Soy products do not prevent onset of vasomotor symptoms in women

A team of investigators led by UC Davis found that eating soy products such as soy milk and tofu did not prevent the onset of hot flashes and night sweats as women entered menopause.

2 Nov 2012

MH6 vaccine shows promise in treating meth addiction

Scientists at The Scripps Research Institute (TSRI) have performed successful tests of an experimental methamphetamine vaccine on rats. Vaccinated animals that received the drug were largely protected from typical signs of meth intoxication.

2 Nov 2012

Maternal dietary acrylamide has negative effect on fetal growth

Pregnant women who consume a diet that is high in acrylamide, found in cooked starchy foods such as toast, chips, and crisps, are more likely to give birth to a small for gestational age baby than women who do not.

24 Oct 2012

EMA CHMP issues positive opinion to Savient's KRYSTEXXA for treatment of chronic gout

Savient Pharmaceuticals, Inc. and its wholly owned subsidiary, Savient Pharma Ireland Limited, announced that the European Medicines Agency's Committee for Medicinal Products for Human Use has completed its scientific assessment and has issued a positive opinion recommending approval of a marketing authorization in the European Union for KRYSTEXXA for the treatment of severe debilitating chronic tophaceous gout in adult patients who may also have erosive joint involvement and who have failed to normalize serum uric acid with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these medicines are contraindicated.

19 Oct 2012

Genzyme announces key data from AUBAGIO Phase III trial on multiple sclerosis

Genzyme, a Sanofi company announced today that key data from the TOWER trial were presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS).

15 Oct 2012