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Role of the transketolase-like 1 gene in the development of the modern human brain

In a new study, researchers demonstrated how transketolase-like 1 (TKTL1) gene expression influenced neocortical neurogenesis in modern humans.

12 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

A single genomic change may have given modern humans an advantage over Neanderthals

A single amino acid change in the transketolase-like 1 (TKTL1) protein may have given modern humans an advantage over more ancient contemporaries like Neanderthals by enabling increased neocortical neurogenesis, researchers report.

9 Sep 2022

Study provides some important new clues to age-related memory decline

One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier.

8 Sep 2022

How a key brain network responds to seasonal shifts in day length

A recent paper examined the difference in neuronal communication in the hypothalamic network that regulates physiological function in response to the photoperiod.

8 Sep 2022

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston.

8 Sep 2022

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny.

6 Sep 2022

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

The brain's cerebral cortex is made up of distinct regions involved in myriad processes, from sensory perception to cognitive functions like memory, attention, and decision-making. University of Pittsburgh neuroscience researchers have found that the properties of one neuron subtype - somatostatin neurons - are specialized in different subregions of the cortex.

6 Sep 2022

The brain and fat communicate directly

Researchers examine the sensory innervation of fat cells within subcutaneous fat deposits.

4 Sep 2022

UTHSC team wins $2.13 million NINDS award to study early neuron development

The National Institute of Neurological Disorders and Stroke has awarded $2.13 million to a University of Tennessee Health Science Center (UTHSC) team studying how neural cells that build a functional brain are generated during embryonic and neonatal life.

2 Sep 2022

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

These days, dragons are keeping Game of Thrones fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded dragon Pogona vitticeps.

2 Sep 2022

Understanding how microglia change their states to adapt to different areas of the brain

In this interview, News Medical speaks to Jeffrey Stogsdill, Ph.D., about his latest research exploring how microglia change their state to adapt to different areas of the brain.

2 Sep 2022

New kind of synapse discovered in neurons’ tiny hairs

Scientists at HHMI's Janelia Research Campus have discovered a new kind of synapse in the tiny hairs on the surface of neurons.

1 Sep 2022

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Cell-based immunotherapy called CAR-T cell therapy has revolutionized the treatment of several cancers.

1 Sep 2022

Scientists uncover how a build-up of harmful protein starts to happen in Parkinson's disease

Scientists at the Francis Crick Institute, UCL and the University of Edinburgh have uncovered how a build-up of harmful protein starts to happen within neurons in Parkinson's disease, ultimately causing nerve cell death.

30 Aug 2022

EPFL scientists uncover key mechanisms underlying the formation of protein tangles in the brain

Neurodegenerative disorders such as Alzheimer's and Parkinson's disease are associated with atypical proteins that form tangles in the brain, killing neurons.

29 Aug 2022

Target blood pressure of 77 mmHg provides no benefit for comatose cardiac arrest survivors

A target blood pressure of 77 mmHg provides no benefit to survival or neurological outcome in comatose cardiac arrest survivors compared with a 63 mmHg target, according to late breaking research presented in a Hot Line session today at ESC Congress 2022.

28 Aug 2022

Mouse embryoids offer a promising model system to spur research into embryonic development and disease

Scientists funded in part by the National Institutes of Health have generated a mouse embryo model, or embryoid, that develops beyond neurulation—formation of the neural tube, which gives rise to the central nervous system—and closely mirrors natural mouse embryos 8.5 days after fertilization.

25 Aug 2022

Brain cells with the same birthdate show distinct connectivity and activity, study finds

Brain cells with the same "birthdate" are more likely to wire together into cooperative signaling circuits that carry out many functions, including the storage of memories, a new study finds.

22 Aug 2022

Increasing the production of new neurons rescues memory defects in mice with Alzheimer's disease

Researchers at the University of Illinois Chicago have discovered that increasing the production of new neurons in mice with Alzheimer's disease (AD) rescues the animals' memory defects.

19 Aug 2022

Neuron News and Research

Role of the transketolase-like 1 gene in the development of the modern human brain

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

A single genomic change may have given modern humans an advantage over Neanderthals

Study provides some important new clues to age-related memory decline

How a key brain network responds to seasonal shifts in day length

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

The brain and fat communicate directly

UTHSC team wins $2.13 million NINDS award to study early neuron development

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

Understanding how microglia change their states to adapt to different areas of the brain

New kind of synapse discovered in neurons’ tiny hairs

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Scientists uncover how a build-up of harmful protein starts to happen in Parkinson's disease

EPFL scientists uncover key mechanisms underlying the formation of protein tangles in the brain

Target blood pressure of 77 mmHg provides no benefit for comatose cardiac arrest survivors

Mouse embryoids offer a promising model system to spur research into embryonic development and disease

Brain cells with the same birthdate show distinct connectivity and activity, study finds

Increasing the production of new neurons rescues memory defects in mice with Alzheimer's disease

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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