Bone News and Research

RSS

Solving a decades-long puzzle in leishmaniasis drug development

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts about 1 million people and kills about 30,000 people around the world every year.

20 Dec 2024

Assessing the impact of gozetotide in PSMA-positive prostate cancer

Gozetotide is a drug for diagnostic application in adults with prostate cancer. It is currently the only diagnostic agent that recognizes PSMA-positive prostate cancer and can therefore identify patients for whom PSMA-targeted therapy with (177Lu)lutetium vipivotide tetraxetan ("Lutetium-177" for short) is an option.

20 Dec 2024

Pioneering research identifies three subtypes of osteosarcoma for better treatment

Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care.

20 Dec 2024

Kaempferol boosts immune tolerance and fights allergies

Kaempferol's role in Treg development is linked to Aldh1a2 activation in dendritic cells, highlighting its potential in suppressing inflammation and allergies.

19 Dec 2024

Surgeons slow to adopt new biomaterials for bone defects

Two million bone transplants are performed worldwide yearly, including half a million in the United States alone. Yet, a QUT-led study has found surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions.

19 Dec 2024

Syphilis family traced to Pre-Columbian Americas

In spring 1495, the Italian campaign of Charles VIII of France was interrupted by an intense outbreak of an apparently unknown illness – a disease of high mortality that quickly engulfed the whole of Europe and left its survivors with life changing impairments to their bodies and minds.

18 Dec 2024

Huntsman Cancer Institute joins innovative clinical trials program for blood cancers

Huntsman Cancer Institute at the University of Utah (the U) has joined other institutions in an innovative clinical trials program designed to match patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with a clinical trial specifically designed for the genetic signature of their disease.

17 Dec 2024

Neanderthal legacy: The surprising genetics behind human tooth size

A recent study identifies key genetic factors—PITX2 expression and Neanderthal-introgressed HS3ST3A1—that contribute to variations in tooth size among modern human populations, especially highlighting differences across ancestries.

17 Dec 2024

WashU Medicine receives $10.8 million grant to advance blood cancer research

Continuing its role as a leader in leukemia research, Washington University School of Medicine in St. Louis has been awarded a five-year, $10.8 million grant to further its exceptional programs in leukemia and other blood cancers.

16 Dec 2024

Gene variant in Andean populations could help predict blood cancer treatment outcomes

Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity of diseases and treatment responses for certain types of blood cancer.

14 Dec 2024

New technique offers safer option for head and neck reconstruction

Sometimes, moving just a few inches can go a long way. Osaka Metropolitan University researchers have developed a promising technique for head and neck reconstruction that shifts the placement of transferred tissue with blood vessels attached, offering a safer, faster option for patients with complex tissue defects, especially those at high risk.

13 Dec 2024

Improving head and neck reconstruction with a modified pedicled flap

Osaka Metropolitan University researchers have developed a promising technique for head and neck reconstruction that shifts the placement of transferred tissue with blood vessels attached, offering a safer, faster option for patients with complex tissue defects, especially those at high risk.

13 Dec 2024

Skin as an immune hero: Fighting infections with self-made antibodies

Researchers uncover how the skin autonomously produces antibodies through specialized immune structures, maintaining microbial balance and preventing infections.

12 Dec 2024

Implantable sensors aid in optimizing bone injury recovery

Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.

12 Dec 2024

High-dose chemotherapy followed by autologous stem cell transplant ineffective for patients with mantle cell lymphoma

Late-breaking research reveals there is no benefit from high-dose chemotherapy followed by autologous stem cell transplant (ASCT) for patients with mantle cell lymphoma (MCL) in remission following their initial treatment.

11 Dec 2024

Daratumumab treatment shows promise for high-risk smoldering multiple myeloma in phase 3 trial

A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM).

10 Dec 2024

Toxic chemical exposure in early life linked to behavioral problems in rats

Early life exposure to a class of endocrine-disrupting chemicals (EDCs) called polychlorinated biphenyls (PCBs) may lead to behavioral problems in rats, according to a new animal study published in the Journal of the Endocrine Society.

10 Dec 2024

Researchers find brain-body immune link in the dural sinuses and skull marrow

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London provides valuable insights into the brain-body immune connection identifying key communication hubs in the dural sinuses and skull bone marrow at the back of the head.

10 Dec 2024

New triplet therapies show promise for relapsed and newly diagnosed leukemias

Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias.

9 Dec 2024

Smoking linked to increased genetic mutations in myelodysplastic syndromes

Smokers with myelodysplastic syndromes (MDS) or a precursor condition had elevated levels of genetic mutations linked to the disease, a new study shows.

9 Dec 2024