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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered RNAi therapeutic targeting glycolate oxidase for the treatment of primary hyperoxaluria type 1.

4 Oct 2018

Researchers decode anti-inflammatory mechanism of vitamin E and its metabolites

Vitamin E's positive effects often fail to manifest themselves as strongly as expected, but sometimes administering vitamin E actually has detrimental effects. An international team has now found a possible cause for this.

3 Oct 2018

New approach promises to forecast cultivar resistance at much earlier stage

Bacterial wilt devastates food crops all over the world. It destroys major crop plants such as tomatoes, potatoes, bananas, ginger and pepper. It occurs in many countries and attacks over 200 plant species.

27 Sep 2018

Lancaster professor aims to understand how genes affect smoking cessation

The Canadian Institute of Health Research has awarded $929,475 to Professor Jo Knight of Lancaster Medical School, Lancaster Data Science Institute and the Department of Psychiatry at the University of Toronto.

25 Sep 2018

Potential drugs to treat neurodegenerative diseases garner $3 million grant

A new four-year, $3 million grant will enable Scripps Research scientists to advance compounds that may protect neurons in diseases caused by toxic protein accumulation, including Parkinson's, ALS, Alzheimer's and Creutzfeldt-Jakob disease.

18 Sep 2018

Abnormal levels of metabolites can reliably predict lung disease in 9/11 firefighters

Abnormal levels of more than two dozen metabolites - chemicals produced in the body as it breaks down fats, proteins and carbohydrates - can reliably predict which Sept. 11 firefighters developed lung disease and which did not, a new analysis shows.

4 Sep 2018

Researchers develop new approach to treating cancer using enzyme therapy

Researchers at The University of Texas at Austin have developed a new approach to treating cancer using enzyme therapy.

29 Aug 2018

Scientists develop urine diagnostic to detect parasitic worms that cause river blindness

Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.

28 Aug 2018

Chemists synthesize garlic ingredient from readily available components

Fresh garlic extracts contain a variety of healthy organosulfur compounds, among which ajoene forms a major oil-extractable ingredient.

24 Aug 2018

Study uncovers link between gut bacteria and 'hedonic eating'

A study of 63 healthy people showed that those with elevated microbiome levels of the metabolite indole - produced when gut bacteria break down the amino acid tryptophan - had stronger function and connectivity in specific areas of the brain's reward network.

24 Aug 2018

NRGene partners with Pure Cannabis Research AG to develop novel cannabis varieties

NRGene, the leading provider of genome-wide sequencing and analysis, has partnered with Pure Cannabis Research AG, a Swiss breeding company that focuses on developing novel cannabis varieties. Pure Cannabis Research AG is a subsidiary of the Pure Holding AG.

22 Aug 2018

A form of vitamin B3 shows potential to prevent acute kidney injury

Acute kidney injury, an often fatal condition without a specific treatment, affects up to 10 percent of all hospitalized adults in the United States and 30-40 percent in low-income countries.

21 Aug 2018

New research confirms link between DDT exposure and autism

The results of a national birth cohort study published today provide biomarker evidence that DDT increases the risk of autism.

15 Aug 2018

Study: Potential new class of drugs may lower heart disease risk by targeting gut microbes

Cleveland Clinic researchers have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut.

7 Aug 2018

New study uses metabolomics to compare lipid profiles of infant formulas and human milk

Metabolomics is the latest omics systems science technology with emerging applications towards psychiatry, personalized medicine, and most recently, precision nutrition research.

3 Aug 2018

Traumatic brain injury biomarker could help predict patient prognosis

A preclinical study has shown that levels of lysophosphatidic acid (LPA) are significantly increased following traumatic brain injury (TBI).

16 Jul 2018

Research reveals why risks of complications in pregnancy vary based on baby's sex

The sex of a baby controls the level of small molecules known as metabolites in the pregnant mother's blood, which may explain why risks of some diseases in pregnancy vary depending whether the mother is carrying a boy or a girl, according to new research from the University of Cambridge.

12 Jul 2018