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Spermidine regulates RIPK1 to combat diabetes and vascular damage

Researchers reveal that spermidine-mediated acetylhypusination of RIPK1 suppresses necroptosis and insulin resistance, offering potential therapeutic strategies for type 2 diabetes.

18 Nov 2024

Engineered SNIPRs transform CAR T-cell precision for safer cancer therapy

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR T-cells. This breakthrough enhances tumor targeting while reducing off-target effects, paving the way for advanced synthetic biology applications.

17 Nov 2024

UBC researchers develop coating to make medical devices safer for patients

University of B.C. researchers have developed a groundbreaking coating that could make medical devices safer for millions of patients, reducing the risks associated with blood clots and dangerous bleeding.

12 Nov 2024

Vitamin D receptor activation slows cell overgrowth in pulmonary hypertension

The study demonstrates that activating the vitamin D receptor (VDR) with calcitriol suppresses cell proliferation in pulmonary arterial smooth muscle cells, potentially reducing disease severity in pulmonary arterial hypertension (PAH).

12 Nov 2024

Traditional and cutting-edge endoscopic modalities in colorectal cancer diagnosis

The evolution of gastrointestinal (GI) endoscopy has transformed CRC diagnostics since its early 20th-century origins.

8 Nov 2024

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

Spatial transcriptomics uncovers tissue niches in multiple sclerosis

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers of multiple sclerosis progression.

8 Nov 2024

Metabolic surgery cuts diuretic dependence in heart failure patients

Pennington Biomedical Research Center researchers at the Metamor Institute, along with colleagues from Our Lady of the Lake and LSU Health-New Orleans, have recently determined that metabolic surgery on patients with heart failure can result in a reduction in the need for oral diuretics, which are used to manage symptoms such as venous and vascular pressures.

7 Nov 2024

Lithuanian scientists develop non-invasive device to improve blood circulation

Impaired blood circulation in the lower limbs is a common health problem among the elderly and one of the most prominent complications of diabetes, called diabetic foot.

7 Nov 2024

Anti-inflammatory cytokine linked to capillary obstruction and cognitive decline in diabetes

Elevated IL-10 in diabetes causes capillary obstruction, linked to cognitive deficits. Blocking IL-10 receptors shows promise for improving brain function.

7 Nov 2024

Researchers awarded Synergy Grant to target tumor vessels and boost immunotherapy

Targeting and customizing blood vessels in tumors to increase T cell infiltration and maintain their function may represent the next breakthrough in cancer therapy.

5 Nov 2024

$Herba Siegesbeckiae subfraction HS-C protects against myocardial I/R injury$

Herba Siegesbeckiae subfraction HS-C protects against myocardial I/R injury

Announcing a new publication for Acta Materia Medica journal. Herba Siegesbeckiae (HS) has been traditionally used for managing cardio- and cerebro-vascular diseases.

5 Nov 2024

New Alzheimer's guidelines focus on risk, not diagnosis, in healthy adults

Researchers from the International Working Group recommend categorizing biomarker-positive, cognitively normal individuals as "at risk" for Alzheimer's to avoid unnecessary diagnoses and emphasize preventive care.

4 Nov 2024

Advanced deep learning technique enhances choroidal vessel visualization

Researchers from Peking University have developed a novel noninvasive choroidal angiography method that enables layer-wise visualization and evaluation of choroidal vessels using deep learning.

4 Nov 2024

Mortality risk higher for those diagnosed with type 2 diabetes at younger ages

Findings indicate younger-onset type 2 diabetes is associated with higher mortality and complications, highlighting the need for focused healthcare strategies.

4 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

New stent sensor developed to detect blockages early

Stents to treat various blockages in the human body can themselves become blocked, but a new sensor developed at the University of Michigan for stents that are used in the bile duct may one day help doctors detect and treat stent blockages early, helping keep patients healthier.

1 Nov 2024

Heart attack triggers sleep increase to aid recovery

A heart attack can trigger a desire to get more sleep, allowing the heart to heal and reduce inflammation - and this happens because the heart sends special signals to the brain, according to a new Mount Sinai study.

1 Nov 2024

Researchers develop novel oxygen-independent therapy for cancer

Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective. An international research team has developed a novel mechanism of action that works without oxygen: polymeric incorporated nanocatalysts target the tumor tissue selectively and switch off the glutathione that the cells need to survive.

1 Nov 2024

Lithuanian scientists develop eco-friendly cellulose matrix for biomedical applications

The efficient use of cellulose - the primary plant scaffold and a major natural building block - could address many issues associated with petroleum-based polymers across various industries.

30 Oct 2024