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Study offers new avenue to pursue in quest for desperately needed treatments for ALS

St. Jude Children's Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis (ALS) disrupt the RNA transport system in nerve cells.

6 Feb 2014

Scientists discover new mechanism governing brain stem cell proliferation

Higher mammals, such as humans, have markedly larger brains than other mammals. Scientists from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden recently discovered a new mechanism governing brain stem cell proliferation.

5 Feb 2014

Findings explain molecular mechanisms underlying microvascular disease in diabetes patients

Patients with diabetes are at increased risk of microvascular complications, which develop when the body's small blood vessels become diseased. One of the most common problems results when wounds fail to heal properly, which can lead to ulcers, chronic infections, and in the most serious cases, limb amputations.

5 Feb 2014

Domain Therapeutics, XOMA to jointly evaluate DTect-All to identify allosteric modulator antibodies

Domain Therapeutics, a biopharmaceutical company specializing in the research and development of new drug candidates targeting G protein-coupled receptors (GPCRs), today announces it has entered into a multi-step collaboration with XOMA Corporation, a leader in the discovery and development of therapeutic antibodies.

4 Feb 2014

New sensor system provides high-quality indoor air without energy losses linked with ventilation

A research consortium being coordinated at Saarland University is developing a novel sensor system for monitoring airborne contaminants that will provide high-quality indoor air without the energy losses typically associated with ventilation.

4 Feb 2014

Discovery may have implications for HIV vaccine research

NIH scientists have discovered a mechanism involved in stabilizing key HIV proteins and thereby concealing sites where some of the most powerful HIV neutralizing antibodies bind, findings with potential implications for HIV vaccine research.

4 Feb 2014

New noninvasive chemical probe detects common species of staph bacteria in the body

Chances are you won't know you've got a staph infection until the test results come in, days after the symptoms first appear. But what if your physician could identify the infection much more quickly and without having to take a biopsy and ship it off for analysis?

From Integrated DNA Technologies 3 Feb 2014

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute discovered in pre-clinical models that dormant prostate cancer cells found in bone tissue can be reawakened, causing metastasis to other parts of the body. Understanding this mechanism of action may allow researchers to intervene prior to disease progression.

31 Jan 2014

VIB and CD3 sign agreement with AstraZeneca for development of novel MALT1 inhibitors

VIB and CD3 (KU Leuven) today announced the signing of a license and collaboration agreement with AstraZeneca for the development of novel MALT1 inhibitors as therapeutics in inflammatory and oncological diseases.

31 Jan 2014

RNAi-based screening offers MPM treatment hope

Research using RNA interference-based screening has identified several potential targets for the treatment of malignant pleural mesothelioma.

31 Jan 2014

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Patients with advanced hepatocellular (or liver) cancer have high mortality rates, with existing drugs demonstrating only a small, but significant survival advantage. By combining a zebrafish model of liver cancer with data from human tumors, researchers from the Icahn School of Medicine at Mount Sinai hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma, the most common form of liver cancer to develop from liver cells.

31 Jan 2014

Researchers gain better understanding of HIV infection through electron microscopy

The human intestinal tract, or gut, is best known for its role in digestion. But this collection of organs also plays a prominent role in the immune system. In fact, it is one of the first parts of the body that is attacked in the early stages of an HIV infection. Knowing how the virus infects cells and accumulates in this area is critical to developing new therapies for the over 33 million people worldwide living with HIV. Researchers at the California Institute of Technology are the first to have utilized high-resolution electron microscopy to look at HIV infection within the actual tissue of an infected organism, providing perhaps the most detailed characterization yet of HIV infection in the gut.

30 Jan 2014

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

30 Jan 2014

Spontaneous tumorigenic transformation of human MSCs can occur during cell culture expansion

Researchers at Erasmus University Medical Center Rotterdam, The Netherlands, led by Dr. Qiuwei Pan and Dr. Luc van der Laan, have discovered that spontaneous tumorigenic transformation of human mesenchymal stem/stromal cells (MSCs) can occur during cell culture expansion, although the frequency is relatively low and often only observed after extensive passage in culture.

30 Jan 2014

New insight into mammalian circadian rhythms could lead to therapies for metabolic disorders

We've all heard about circadian rhythm, the roughly 24-hour oscillations of biological processes that occur in many living organisms. Yet for all its influence in many aspects of our lives - from sleep to immunity and, particularly, metabolism - relatively little is understood about the mammalian circadian rhythm and the interlocking processes that comprise this complex biological clock.

30 Jan 2014

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Dormant prostate cancer cells in bone tissue can be reawakened to cause secondary tumours, according to new research published in Endocrine-Related Cancer. Targeting the wake-up call could prevent metastasis and improve prostate cancer survival rates.

29 Jan 2014

Scientists develop monoclonal antibodies that may lead to new, innovative treatments for cancer patients

Using monoclonal antibodies to fight cancer is a complex, yet promising area of study. At Memorial Sloan Kettering Cancer Center, physician-scientists have focused their attention on expanding the current therapeutic antibody repertoire, and believe a newly developed platform will do just that - ultimately leading to new and innovative treatments for cancer patients with a broad range of malignancies.

29 Jan 2014

Molecule News and Research

Study offers new avenue to pursue in quest for desperately needed treatments for ALS

Scientists discover new mechanism governing brain stem cell proliferation

Findings explain molecular mechanisms underlying microvascular disease in diabetes patients

Domain Therapeutics, XOMA to jointly evaluate DTect-All to identify allosteric modulator antibodies

New sensor system provides high-quality indoor air without energy losses linked with ventilation

Discovery may have implications for HIV vaccine research

New noninvasive chemical probe detects common species of staph bacteria in the body

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

VIB and CD3 sign agreement with AstraZeneca for development of novel MALT1 inhibitors

RNAi-based screening offers MPM treatment hope

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Researchers gain better understanding of HIV infection through electron microscopy

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

Spontaneous tumorigenic transformation of human MSCs can occur during cell culture expansion

New insight into mammalian circadian rhythms could lead to therapies for metabolic disorders

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Scientists develop monoclonal antibodies that may lead to new, innovative treatments for cancer patients

New molecule reduces diabetic patients' higher risk of developing dementia, Alzheimer's

Changes in SirT1 protein can prevent excess metabolic stress associated with obesity, diabetes and aging

New data on extending the serum half-life of albumin in vivo announced by Novozymes Biopharma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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