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SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

A new study discusses the effect of the Omicron variant’s mutations on its binding efficiency to the ACE2 receptor.

9 Dec 2021

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Researchers from the Centro de Investigaciones Biológicas Margarita Salas have been investigating one of the mutations that typically appear in the Delta variant.

9 Dec 2021

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Scientists attempt to understand the evolution of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

New study results provide evidence that the binding between SARS-CoV-2 RBD and host ACE2 receptor is aided by the glycosylation on each protein.

9 Dec 2021

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

Researchers have developed Nanocovax, a COVID-19 subunit vaccine based on recombinant protein technology to produce the extracellular (soluble) portion of the S protein of SARS-CoV-2.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

A team of researchers set out to build a full-length, membrane-embedded spike to study its conformational dynamics at the atomic level using molecular dynamics simulations to understand better how this important component of the virus machinery works.

8 Dec 2021

Quantum mechanical characterization of SARS-CoV-2 Omicron variant interaction with human ACE2 receptor

Researchers from Universite Grenoble Alpes have been investigating the changes in the Omicron variant RBD and how they affect ACE2 binding.

8 Dec 2021

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

Researchers from the Management and Science University in Malaysia have used computational tools to investigate the new variant.

8 Dec 2021

Does a COVID-19 vaccine booster improve the immune response of a poor responder?

A new study has focussed on determining the levels of nAb in individuals who received the second and third doses of the RNA vaccines developed by Pfizer and Moderna.

8 Dec 2021

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Researchers investigate the conformational dynamics of the SARS-CoV-2 RBD using the atomistic molecular dynamics simulation method.

7 Dec 2021

Homologous mRNA and heterologous vaccines elicit high immune responses

New study findings show that homologous mRNA or heterologous vaccination induces the highest immune responses due to high RBD- and S1-specific antibodies.

7 Dec 2021

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

The current study not only analyses the mutations in the Omicron spike variant but classifies various combinations of spike mutations into groups.

7 Dec 2021

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

A new study provides understanding of the intricate roles and functions of the different elements of spike proteins and shows how the spike protein samples a crowded surface of its host cell via the glycans.

7 Dec 2021

Study suggests algal polysaccharide may be a promising anti-COVID-19 candidate

Researchers from the Rensselaer Polytechnic Institute have been investigating the potential of rhamnan sulfate as an antiviral agent.

7 Dec 2021

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

In a recent study conducted at Yale University, USA, scientists have investigated the immunogenicity of mRNA-based coronavirus disease 2019 (COVID-19) vaccine candidates encoding the spike proteins of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. The findings reveal that the vaccines induce robust immune responses against SARS-CoV-2 variants. The study is currently available on the bioRxiv* preprint server.

6 Dec 2021

SARS-CoV-2 S2 immunization as a pan-coronavirus vaccine approach

A new mouse model suggests that prior HCoV-OC43 S immunity primes neutralising antibody responses to otherwise subimmunogenic SARS-CoV-2 S exposure as well as promotes S2-targeting antibody responses.

6 Dec 2021

Scientists find infection of sustentacular cells in the olfactory epithelium of COVID-19 patients

It is now widely known that COVID-19 is associated with the transient or long-term loss of olfaction (the sense of smell) but the mechanisms remain obscure.

6 Dec 2021

ACE2 News and Research

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

Quantum mechanical characterization of SARS-CoV-2 Omicron variant interaction with human ACE2 receptor

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

Does a COVID-19 vaccine booster improve the immune response of a poor responder?

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Homologous mRNA and heterologous vaccines elicit high immune responses

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

Study suggests algal polysaccharide may be a promising anti-COVID-19 candidate

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

SARS-CoV-2 S2 immunization as a pan-coronavirus vaccine approach

Scientists find infection of sustentacular cells in the olfactory epithelium of COVID-19 patients

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