Preclinical News and Research

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Animal research reveals metabolic differences between tirzepatide and semaglutide

New animal research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May), reveals distinct metabolic adjustments to tirzepatide and semaglutide treatment, with tirzepatide temporarily increasing energy expenditure and semaglutide initially reducing energy expenditure.

14 May 2025

Once-daily oral treatment shows positive results in first human study for obesity treatment

A first-in-human study of an investigational once-daily oral treatment for obesity (SYNT-101) demonstrated positive preliminary data for the safe and effective redirection of nutrient absorption into the lower intestine, the weight loss and metabolic management mechanism behind gastric bypass surgery.

14 May 2025

NIH grant supports Wayne State University research on protecting vision in people with diabetes

A four-year, $2.33 million grant from the National Eye Institute of the National Institutes of Health to Wayne State University is supporting research focused on improving and preserving vision and eye health in those with diabetes.

13 May 2025

‘Cell line atlas’ can help better understand biliary tract cancer biology

Advanced biliary tract cancer (BTC) includes cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. BTC is a rare and aggressive group of cancers, carrying one of the worst prognoses in all of oncology.

12 May 2025

Precision nano therapy targets tumor nerves in pancreatic cancer

Announcing a new publication for Acta Materia Medica journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer.

8 May 2025

New brain imaging method shows promise for early diagnosis of Parkinson's disease

An international team, led by researchers at the Champalimaud Foundation (CF), has shown – for the first time in a realistic way – that it may be possible to diagnose Parkinson's disease (PD) years before it becomes untreatable, by scanning people's brains with functional magnetic resonance imaging (fMRI).

8 May 2025

Study reveals potential new strategy to prevent or slow progression of Type 1 diabetes

A study co-led by Indiana University School of Medicine researchers presents a potential new strategy to prevent or slow the progression of Type 1 diabetes by targeting an inflammation-related protein known to drive the disease.

7 May 2025

Combining vagus nerve stimulation with therapy provides lasting PTSD relief

In a first-of-its-kind clinical study, scientists at The University of Texas at Dallas and Baylor University Medical Center showed that patients with treatment-resistant PTSD were symptom-free up to six months after completing traditional therapy paired with vagus nerve stimulation (VNS).

5 May 2025

Disrupted muscle clocks linked to accelerated aging in shift workers

Muscle cells contain their own circadian clocks and disrupting them with shift work can have a profound impact on aging, according to new research.

5 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

Getting active in midlife may boost brain resilience to Alzheimer’s

In cognitively healthy middle-aged adults at risk for Alzheimer’s disease, becoming physically active, especially in line with WHO guidelines, was linked to lower brain amyloid burden. Remaining sedentary was associated with reduced cortical thickness in brain regions vulnerable to AD.

1 May 2025

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Folic acid plays a dual role in breast cancer depending on dose and context. While moderate intake may reduce risk, high levels or genetic variants disrupting metabolism may promote tumor progression via altered DNA methylation.

30 Apr 2025

Licensing agreed for Optimer as novel vaccine adjuvant

Aptamer Group plc, the leading developer of next-generation synthetic binders delivering innovation to the life science industry, has entered into a global licensing agreement with the University of Glasgow for the commercial use of a developed panel of Optimer binders as vaccine adjuvants in the swine health sector.

30 Apr 2025

New antiviral compounds show broad protection against COVID-19 variants

Novel Mpro inhibitors exhibit broad activity against SARS-CoV-2 and other coronaviruses.

30 Apr 2025

Metrion Biosciences launches NaV1.9 high-throughput screening assay to strengthen screening portfolio and advance research on new medicines for pain

Metrion Biosciences ("Metrion"), the specialist preclinical contract research organization (CRO) and a global leader in ion channel services, today announced the launch of its validated, high-throughput NaV1.9 screening assay to advance discovery and development of novel pain therapeutics.

28 Apr 2025

Preclinical News and Research

Animal research reveals metabolic differences between tirzepatide and semaglutide

Once-daily oral treatment shows positive results in first human study for obesity treatment

NIH grant supports Wayne State University research on protecting vision in people with diabetes

‘Cell line atlas’ can help better understand biliary tract cancer biology

Precision nano therapy targets tumor nerves in pancreatic cancer

New brain imaging method shows promise for early diagnosis of Parkinson's disease

Study reveals potential new strategy to prevent or slow progression of Type 1 diabetes

Combining vagus nerve stimulation with therapy provides lasting PTSD relief

Disrupted muscle clocks linked to accelerated aging in shift workers

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Getting active in midlife may boost brain resilience to Alzheimer’s

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Licensing agreed for Optimer as novel vaccine adjuvant

New antiviral compounds show broad protection against COVID-19 variants

Metrion Biosciences launches NaV1.9 high-throughput screening assay to strengthen screening portfolio and advance research on new medicines for pain

Humanized antibody dismantles metabolic barrier as a potential cancer immunotherapy

UQ begins first human trial of immunotherapy for Type 1 diabetes

Dana-Farber experts present innovative cancer studies at the 2025 AACR Annual Meeting

MD Anderson researchers present promising clinical trial results at AACR 2025

Global survey highlights barriers to VR haptics in dental education

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