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Discovery of novel form of regulation of the GLI1 gene

The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer.

14 Nov 2005

Molecular origins of diabetes

An unexpected twist to a discovery reported just two months ago may significantly improve our understanding about the molecular origins of diabetes.

14 Nov 2005

Researchers can now identify patients likely to respond to cancer drug therapy

Researchers at UCLA's Jonsson Cancer have identified key characteristics in certain deadly brain tumors that make them 51 times more likely to respond to a specific class of drugs than tumors in which the molecular signature is absent.

13 Nov 2005

Number of men interested in donating sperm has declined significantly

A study by a leading UK fertility centre has found that the numbers of men - especially students - coming forward as potential sperm donors fell sharply after 2000, almost certainly due to growing awareness that changes in the law would be removing the right to anonymity.

13 Nov 2005

University of Alberta researchers pioneer gene therapy to restore alveoli and lung capillaries in damaged rat lungs

The good news is that medical advances in perinatal care have allowed us to save many more premature babies. The bad news is they're often at risk of developing bronchopulmonary dysplasia--a chronic lung disease caused by having to place the tiny infants on ventilators and oxygen-rich therapy for acute respiratory failure.

13 Nov 2005

New understanding of the disease process involved in atherosclerosis

The progression of the artery-clogging disease atherosclerosis is linked to the inability of specialized bone marrow cells to continuously repair damage to the arterial lining, Duke University Medical Center researchers have demonstrated.

13 Nov 2005

Link between diet and epileptic seizures studied

Although the high-fat, calorie-restricted ketogenic diet (KD) has long been used to prevent childhood epileptic seizures that are unresponsive to drugs, physicians have not really understood exactly why the diet works.

13 Nov 2005

Lifelong exercise decreases cellular aging in the brain

In the first study to show that lifelong exercise decreases cellular aging in the brain, scientists from the McKnight Brain Institute of the University of Florida say that moderately active rats have healthier DNA and more robust brain cells than their less active counterparts. The research was presented at the Society for Neuroscience's 35th annual meeting in Washington, D.C.

13 Nov 2005

Maternal malaria and gravidity interact to modify infant susceptibility to malaria

Every year at least 30 million women in malaria-endemic areas of Africa become pregnant. Many of them develop placental malaria, a pregnancy-specific form of the disease, which frequently results in low birth weight of the child.

13 Nov 2005

Genetic factors versus environmental factors in assessing malaria risk

Humans exposed to malaria get infected and sick to varying degrees, and some of that variation is due to differences in genetic makeup between individuals. But how important are genetic factors compared with environmental ones?

13 Nov 2005

Adverts for SSRI antidepressants misleading

Consumer ads for a class of antidepressants called SSRIs often claim that depression is due to a chemical imbalance in the brain, and that SSRIs correct this imbalance, but these claims are not supported by scientific evidence, say researchers in PLoS Medicine.

13 Nov 2005

Phenolic compounds in olive oil may explain cardiovascular health benefits associated with Mediterranean Diet

Phenolic compounds in olive oil, which have antioxidant, anti-inflammatory and anti-clotting properties, may explain cardiovascular health benefits associated with the so-called Mediterranean Diet, according to a new study in the Nov. 15, 2005, issue of the Journal of the American College of Cardiology.

13 Nov 2005

Cellular signal may determine life or death for damaged brain cells

Scientists at the Universities of Heidelberg and Ulm and a unit of the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have discovered that a specific signal within brain cells may determine whether they live or die after a stroke.

13 Nov 2005

Promising functional readouts of immunity in a blood-stage malaria vaccine trial

A malaria vaccine remains the most desired tool to combat the worsening malaria epidemic in many developing countries. Pierre Druilhe and colleagues (from the Institut Pasteur in Paris) have completed the first human trial of a vaccine based on MSP3, a protein present on the surface of the malaria parasite, with very encouraging results.

13 Nov 2005

Obstructive sleep apnea significantly increases the risk of stroke

An observational study of more than 1,000 patients at the Yale Center for Sleep Medicine found that obstructive sleep apnea significantly increases the risk of stroke or death from any cause, and that the risk is linked to sleep apnea severity.

13 Nov 2005

Physical activity enhances long-term quality of life in older adults

Exercise is a lot like spinach … everybody knows it's good for you; yet many people still avoid it, forgoing its potential health benefits.

13 Nov 2005

Antibiotics overprescribed for sore throat

Physicians prescribe antibiotics for more than half of children with sore throat, exceeding the expected prevalence of strep throat, and used nonrecommended antibiotics for 27 percent of children who received an antibiotic prescription, according to a study in the November 9 issue of JAMA: The Journal of the American Medical Association.

13 Nov 2005