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UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation.

22 Dec 2022

DISCO-MS technology enables the study of diseases at their earliest stages

How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack.

22 Dec 2022

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

A recent Nature Cancer study documented that individuals with B cell lymphomas (LY) and multiple myeloma (MM) developed potent infection neutralization capabilities against several SARS-CoV-2 variants of concern (VoCs).

22 Dec 2022

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

A new study in mice has helped illuminate how the brain's primary motor cortex (M1) – a brain region most commonly associated with control of motor functions – helps suppress dimensions of neuropathic pain.

22 Dec 2022

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases.

22 Dec 2022

Research serves as a platform to identify therapeutic drugs for schizophrenia

Inflammation and overactivation of the immune system in the brain can cause loss of synapses and the death of neurons, leading to neurodegenerative and psychiatric diseases.

22 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

Extracellular vesicles enhance cancer immunotherapy

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor.

22 Dec 2022

3D neutron tomography reveals water diffusion across the bone material

What keeps bones able to remodel themselves and stay healthy? A team from Charité Berlin has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load.

22 Dec 2022

Impact of epigenetics on the clinical management of cancer patients

Dr. Manel Esteller and Dr. Verónica Dávalos, researchers at the Josep Carreras Leukaemia Research Institute, describe in a new article the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments.

22 Dec 2022

Study helps understand why some people have persistent smell loss after COVID-19 infection

The reason some people fail to recover their sense of smell after COVID-19 is linked to an ongoing immune assault on olfactory nerve cells and an associated decline in the number of those cells, a team of scientists led by Duke Health report.

21 Dec 2022

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

21 Dec 2022

Researchers unravel how one of the crucial early steps on the path of life could have happened

One-hundred fifty years ago, Charles Darwin speculated that life likely originated in a warm little pond. There, Darwin supposed, chemical reactions and the odd lightning strike might have led to chains of amino acids that, over time, became more and more complex until the beginnings of life emerged.

21 Dec 2022

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Omicron subvariants effectively escape B-cell immune responses by modifying neutralizing antibody epitopes.

21 Dec 2022

New methods can advance the development of rapid diagnostics for many infectious diseases

Two companion studies report new artificial intelligence approaches for identification of molecular "fingerprints" for specific infections. The methods, used here to derive a fingerprint for COVID-19, can advance the development of rapid diagnostics for many infectious diseases.

21 Dec 2022

Recapitulating early stages of the human body plan in a dish

Although Michelangelo's masterpiece David captured the magnificence of the human body - how this exquisite body plan is exactly established during human development has puzzled scientists for more than a century.

21 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

A microbiologist at the University of Massachusetts Amherst has received a National Institutes of Health grant to support research aimed ultimately at developing new, more effective treatments for tuberculosis (TB).

21 Dec 2022

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

A study conducted in Serrana, a small town in São Paulo state used as a model for COVID-19 vaccination in Brazil, shows that mass vaccination reduced the severe case and death rates even while the gamma and delta variants were circulating.

21 Dec 2022

Research could pave way for designing more strategically engineered transplants to treat cartilage damage in the joints

A collaborative team, which includes scientists from the Terasaki Institute for Biomedical Innovation, University of Illinois Chicago, and Pohang University of Science and Technology has elucidated some key points on how the generation of cartilage in the joints is facilitated and how alternative bone formation can be avoided.

21 Dec 2022

B Cell News and Research

UC San Diego researchers rewrite the textbook on gene regulation

DISCO-MS technology enables the study of diseases at their earliest stages

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

Research serves as a platform to identify therapeutic drugs for schizophrenia

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

Extracellular vesicles enhance cancer immunotherapy

3D neutron tomography reveals water diffusion across the bone material

Impact of epigenetics on the clinical management of cancer patients

Study helps understand why some people have persistent smell loss after COVID-19 infection

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

Researchers unravel how one of the crucial early steps on the path of life could have happened

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

New methods can advance the development of rapid diagnostics for many infectious diseases

Recapitulating early stages of the human body plan in a dish

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

Research could pave way for designing more strategically engineered transplants to treat cartilage damage in the joints

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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