Efficacy News and Research

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New study adds evidence to efficacy and safety of low-dose vaginal estrogen

Despite its proven effectiveness in treating the genital symptoms of menopause, low-dose vaginal estrogen therapy remains underused largely because of misperceptions regarding its safety.

19 Dec 2018

Study may identify new diagnostics and treatment option for CVD

Forty-two percent of all deaths in the United States are related to cardiovascular disease. According to the Global Cardiovascular Drugs Market Forecast, by 2030 the number of deaths from CVD will rise to 23.6 million per year in the U.S. alone.

19 Dec 2018

A promising, effective vaccine for common respiratory disease

Skin vaccination using a microneedle patch that contains the inactivated respiratory syncytial virus (RSV) and a compound that stimulates immune responses to the virus has been found to enhance protection against this serious disease and reduce inflammation in the body after exposure to the virus, according to a study led by Georgia State University.

18 Dec 2018

Intraocular injection improves vision in a form of congenital retinal blindness

A new treatment for patients with a form of congenital retinal blindness has shown success in improving vision, according to results published today in Nature Medicine led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.

18 Dec 2018

New bacterial species may help fight obesity and metabolic disorders

The MyNewGut project has discovered new bacterial species and strains in healthy people that seem to be effective against obesity, metabolic and mental disorders related to stress and obesity (e.g. depression).

17 Dec 2018

Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate

Vinorelbine Bitartrate, a semi-synthetic vinca alkaloid was approved by the FDA for breast cancer treatment, as it has been proven to be beneficial for first line of defense and subsequent therapies. But its hydrophilic and thermolabile structure causes hindrance to oral clinical translation.

17 Dec 2018

CTF along with NTAP and Sage announce first-ever open data portal for neurofibromatosis

The Children's Tumor Foundation, together with the Neurofibromatosis Therapeutic Acceleration Program and Sage Bionetworks, has announced the first-ever open data portal for scientific research results in the field of neurofibromatosis.

17 Dec 2018

Eisai enters into agreement with Eurofarma for its anti-obesity agent lorcaserin

Eisai Co., Ltd. has entered into an agreement to grant exclusive development and marketing rights for its anti-obesity agent lorcaserin hydrochloride in Brazil to Eurofarma Laboratorios S.A. Under this agreement, Eisai will supply Eurofarma with lorcaserin. Eisai will receive a one-time contractual payment and is eligible for milestone payments for sales in Brazil.

17 Dec 2018

New drug shows promise in treating sarcomas

A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports.

14 Dec 2018

Recent developments and challenges in hMAT inhibitors

Zhu et al. have reviewed the recent developments in the knowledge about the binding, inhibitory mechanisms and structure-activity relationships of hSERT, hNET and hDAT, which are primary human monoamine transporters hMATs.

14 Dec 2018

Study finds drug targets for Ebola, Dengue, and Zika viruses

No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. New research from the Gladstone Institutes and UC San Francisco may finally change that. Scientists identified key ways the three viruses hijack the body's cells, and they found at least one potential drug that can disrupt this process in human cells.

13 Dec 2018

GW researchers review studies on treatments for prurigo nodularis

Prurigo nodularis is a disabling chronic skin condition characterized by severely itchy, crusty, firm papules and nodules that often occur on the arms and legs, but can appear diffusely on the body. The pathogenesis of prurigo nodularis is poorly understood, as this condition has been associated with a broad array of primary skin and underlying medical diseases affecting the liver, kidneys, and blood.

13 Dec 2018

Research identifies nerve-signaling pathway behind sustained pain after injury

A toddler puts her hand on a hot stove and swiftly withdraws it. Alas, it's too late--the child's finger has sustained a minor burn. To soothe the pain, she puts the burned finger in her mouth.

13 Dec 2018

UAlberta scientists identify biomarkers for detecting Alzheimer's disease in saliva samples

University of Alberta scientists have identified three biomarkers for detecting mild cognitive impairment and Alzheimer's disease in saliva samples. The research has promising results for application in a clinical setting.

13 Dec 2018

Advanced spectroscopic techniques used to prepare, characterize major degradation products of pralatrexate injection

The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized, and characterized using advanced spectroscopic techniques such as NMR, HR-MS, and IR.

13 Dec 2018

Study assesses safety and efficacy of new treatment for pancreatic cancer

Gemcitabine given in combination with nab-paclitaxel is the standard of care for patients with advanced pancreatic cancer. This practice, however, rests on data obtained from several recent clinical trials enrolling patients with pancreatic cancer who skewed younger and in better overall condition than most.

13 Dec 2018

New substance could improve efficacy of established breast cancer treatments

Physicians from Karl Landsteiner University of Health Sciences in Krems (Austria) demonstrate potential for clinical application, collaborating with research groups from Germany, the USA, and China.

13 Dec 2018

Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines

On Wednesday, December 12, 2018, Brazil's Butantan Institute signed a collaboration agreement with Merck Sharp & Dohme (MSD) to develop dengue vaccines.

12 Dec 2018

Virginia Tech and UC San Diego researchers team up to develop nonopioid drug for chronic pain

Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug -- now in its earliest stages -- that can treat certain types of chronic pain without the addictive consequences of opioids.

12 Dec 2018

Targeting biochemical pathway may lead to new therapies for alleviating symptoms of anxiety disorders

According to some estimates, up to one in three people around the world may experience severe anxiety in their lifetime.

12 Dec 2018

Efficacy News and Research

New study adds evidence to efficacy and safety of low-dose vaginal estrogen

Study may identify new diagnostics and treatment option for CVD

A promising, effective vaccine for common respiratory disease

Intraocular injection improves vision in a form of congenital retinal blindness

New bacterial species may help fight obesity and metabolic disorders

Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate

CTF along with NTAP and Sage announce first-ever open data portal for neurofibromatosis

Eisai enters into agreement with Eurofarma for its anti-obesity agent lorcaserin

New drug shows promise in treating sarcomas

Recent developments and challenges in hMAT inhibitors

Study finds drug targets for Ebola, Dengue, and Zika viruses

GW researchers review studies on treatments for prurigo nodularis

Research identifies nerve-signaling pathway behind sustained pain after injury

UAlberta scientists identify biomarkers for detecting Alzheimer's disease in saliva samples

Advanced spectroscopic techniques used to prepare, characterize major degradation products of pralatrexate injection

Study assesses safety and efficacy of new treatment for pancreatic cancer

New substance could improve efficacy of established breast cancer treatments

Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines

Virginia Tech and UC San Diego researchers team up to develop nonopioid drug for chronic pain

Targeting biochemical pathway may lead to new therapies for alleviating symptoms of anxiety disorders

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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