Efficacy News and Research

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Researchers identify effective ketamine dosage levels for patients with treatment-resistant depression

A study led by Massachusetts General Hospital investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression.

11 Oct 2018

New vaccine shows effective protection in animal models of Lassa fever

Lassa fever belongs to the same class of hemorrhagic fevers as Ebola. Like Ebola, it has been a major health threat in Western Africa, infecting 100,000-300,000 people and killing 5,000 per year.

11 Oct 2018

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Carnegie's Department of Embryology scientist Steven Farber and team have been awarded a 5-year $3.3-million NIH grant to identify novel pharmaceuticals for combatting a host of diseases associated with altered levels of lipoproteins like LDL ("bad cholesterol").

11 Oct 2018

UNC researchers awarded $3.8 million grant to develop ultra-long-acting antiretroviral formulations

It has been well established that HIV transmission can be efficiently halted by effective treatment of those infected or by pre-exposure prophylaxis of individuals at risk of exposure.

11 Oct 2018

Molecular mechanisms behind therapeutic action of ancient herbal medicine discovered

Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for a therapeutic action of an ancient herbal medicine used across Africa to treat various illnesses, including epilepsy.

10 Oct 2018

Chewing gum could be a strategy to help reduce vitamin deficiency

Nearly 15 percent of all chewing gum varieties sold promise to provide health-enhancing supplements to users, so Penn State researchers studied whether two vitamin-supplemented products were effective at delivering vitamins to the body. Their results validate the concept of gum as an effective delivery system for at least some vitamins.

10 Oct 2018

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Epizyme, Inc., a clinical-stage company developing novel epigenetic therapies, announced today that updated efficacy and safety data from the fully enrolled cohort of epithelioid sarcoma (ES) patients in its ongoing Phase 2 trial of tazemetostat will be presented in a poster discussion session at the European Society for Medical Oncology (ESMO) 2018 Congress to be held October 19-23 in Munich, Germany.

10 Oct 2018

Study: Sarcoma patients poorly informed about risk of interactions with anti-cancer drugs

Sarcoma patients show great openness to the use of complementary alternative medicines (CAMs) for supportive care, but they are poorly informed about safety issues and risk of interactions with anti-cancer drugs, a study to be presented at ESMO 2018 reported.

10 Oct 2018

Researchers devise a simple way to boost efficacy of malarial TBVs

For decades, scientists have been trying to develop a vaccine that prevents mosquitoes from spreading malaria among humans.

9 Oct 2018

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Personal Genome Diagnostics, Inc., a leader in cancer genomics and pioneer in liquid biopsy, today reported that its non-invasive, pan-cancer plasma assay is being used in an important new clinical trial, Nivolumab, Ipilimumab in Patients With Hyper Mutated Cancers Detected in Blood, led by the Cancer Research Institute and Canadian Cancer Trials Group.

9 Oct 2018

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

New genome editing tool used to heal genetic disease

Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease.

8 Oct 2018

Lyra Therapeutics announces presentation of Phase 1 clinical data for LYR-210 in CRS patients

Lyra Therapeutics, Inc., a clinical-stage biotechnology company developing medicines precisely designed to target ear, nose and throat diseases, today announced the presentation of Phase 1 clinical data for the company's lead therapeutic, LYR-210, for chronic rhinosinusitis, a debilitating disease caused by inflammation of the paranasal sinus tissues that affects approximately 27 million people, or 11% of the adult population in the U.S.

8 Oct 2018

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Verastem, Inc., focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that the National Comprehensive Cancer Network added COPIKTRA (duvelisib) capsules to the Clinical Practice Guidelines in Oncology (NCCN Guidelines) for follicular lymphoma.

8 Oct 2018

Intact Vascular to present TOBA II pivotal clinical trial data at VIVA Conference

Intact Vascular, Inc., a developer of medical devices for minimally invasive peripheral vascular procedures, today announced that data from its Tack Optimized Balloon Angioplasty II pivotal clinical trial will be presented at the 15th Annual VIVA Conference in Las Vegas, NV on November 5-8.

8 Oct 2018

The feds’ termination of a tiny contract inflames bitter fight over fetal tissue

Federal health officials announced late last month they had terminated their contract with a company that supplies human fetal tissue for medical research and were checking that similar contracts, as well as studies conducted with that tissue, comply with federal law.

8 Oct 2018

Joint research team discovers potential new treatment for severe malaria

Scientists from Massachusetts Institute of Technology, Singapore-MIT Alliance for Research and Technology and Nanyang Technological University, Singapore have discovered a potential treatment that could be effective against severe malaria and even drug-resistant malaria.

8 Oct 2018

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Novartis today announced that both the US Food and Drug Administration and European Medicines Agency have accepted the company's New Drug Application and Marketing Authorization Application respectively, for investigational oral, once-daily siponimod (BAF312) for the treatment of secondary progressive multiple sclerosis in adults.

8 Oct 2018

Immunotherapy effective for individuals with inherited form of skin cancer

Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year's Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics.

8 Oct 2018

Scientists discover new molecular pathway that controls colorectal cancer development

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.

8 Oct 2018

Efficacy News and Research

Researchers identify effective ketamine dosage levels for patients with treatment-resistant depression

New vaccine shows effective protection in animal models of Lassa fever

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

UNC researchers awarded $3.8 million grant to develop ultra-long-acting antiretroviral formulations

Molecular mechanisms behind therapeutic action of ancient herbal medicine discovered

Chewing gum could be a strategy to help reduce vitamin deficiency

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Study: Sarcoma patients poorly informed about risk of interactions with anti-cancer drugs

Researchers devise a simple way to boost efficacy of malarial TBVs

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

New genome editing tool used to heal genetic disease

Lyra Therapeutics announces presentation of Phase 1 clinical data for LYR-210 in CRS patients

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Intact Vascular to present TOBA II pivotal clinical trial data at VIVA Conference

The feds’ termination of a tiny contract inflames bitter fight over fetal tissue

Joint research team discovers potential new treatment for severe malaria

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Immunotherapy effective for individuals with inherited form of skin cancer

Scientists discover new molecular pathway that controls colorectal cancer development

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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