Amino Acid News and Research

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Amino Acid is one of several molecules that join together to form proteins. There are 20 common amino acids found in proteins.

SARS-CoV-2 zoonotic transmission prediction using ACE2 receptor variation is limited

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Glasgow assessed the variation in angiotensin-converting enzyme 2 (ACE2) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host prediction.

19 May 2022

Epistatic drift leads to unpredictability in protein evolution

A critical goal in genetics and evolution is predicting the effects of mutations that may happen in the future and inferring the effects of those that happened in the past.

19 May 2022

Genetic variants may help explain the variability in COVID-19 severity, study suggests

Though underlying medical conditions play an important role, many aspects of why COVID-19 severity can differ vastly from one to another has remained unclear.

19 May 2022

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers analyze the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of MHC-I.

19 May 2022

Scientists report complex mutation pattern of Omicron BA.2

Recently, scientists have studied the mutation profile of SARS-CoV-2 Omicron BA.2 and analyzed its outcome based on the interaction with receptor and/or monoclonal antibodies.

18 May 2022

Camelid IFNs could play important role in combating emerging zoonotic pathogens

In a recent study published in the Developmental & Comparative Immunology journal, the discovery of a novel form of mammalian interferon-Beta (IFN-β) with four cysteine residues from the dromedary camel and the five remaining members of the mammalian suborder Tylopoda is described.

17 May 2022

Exploring mutational energetics and the role of arginine blockers in COVID-19 treatments

A new study aimed to describe the roles of certain specific mutations in SARS-CoV-2 strains, with respect to their ability to conformationally stabilize S-protein structure resulting in enhanced receptor-binding domain ACE2 binding.

17 May 2022

Study suggests the seasonal H1N1 flu virus may be a direct descendant of the 1918 influenza strain that caused a global flu pandemic

A new study published in Nature Communications implemented recent advances in nucleic acid recovery to sequence one complete and two partial 1918 influenza virus genomes from specimens sampled in Berlin and Munich.

16 May 2022

CDC study reveals hybrid SARS-CoV-2 spike from Delta/Omicron recombination event

The US Centers for Disease Control and Prevention (CDC) has conducted national-level genomic surveillance to identify and characterize delta-omicron recombinant genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A total of nine genomes with a hybrid delta-omicron spike protein have been identified.

14 May 2022

Hormonal shift during menopause changes women’s blood metabolite profile

In midlife, the risk of cardiometabolic diseases increases in women more rapidly than in men. A study performed at the Faculty of Sport and Health Sciences of the University of Jyväskylä shows that changes in blood metabolite profile accompany the shift in sex hormone levels during menopause.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

Researchers retrieved the first-ever sequenced spike (S) protein structures of the original Wuhan-Hu 1 SARS-CoV-2 strain, the Alpha, Delta, Delta-plus variants, and Omicron sub-variants BA.1 and BA.2 and compared their structural and molecular level variations.

10 May 2022

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

A study recently published in the journal Cell Host & Microbe has described that all three sublineages of the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit similar host cell entry efficiency and are neutralized equally by antibodies generated in response to coronavirus disease 2019 (COVID-19) booster vaccination

10 May 2022

Amino Acid News and Research

Further Reading

SARS-CoV-2 zoonotic transmission prediction using ACE2 receptor variation is limited

Epistatic drift leads to unpredictability in protein evolution

Genetic variants may help explain the variability in COVID-19 severity, study suggests

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Scientists report complex mutation pattern of Omicron BA.2

Camelid IFNs could play important role in combating emerging zoonotic pathogens

Exploring mutational energetics and the role of arginine blockers in COVID-19 treatments

Study suggests the seasonal H1N1 flu virus may be a direct descendant of the 1918 influenza strain that caused a global flu pandemic

CDC study reveals hybrid SARS-CoV-2 spike from Delta/Omicron recombination event

Hormonal shift during menopause changes women’s blood metabolite profile

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

Study reveals immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients

Changes in gut microbiome impact depression

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

Study identifies two new Omicron lineages associated with a resurgence in infections in South Africa

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Exercise can have a beneficial effect on factors contributing to NAFLD, study shows

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