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New discovery could lead to faster and more effective treatments for chronic health complications

A world-first discovery by researchers at Monash University and The University of Queensland could lead to faster and more effective treatments for chronic health complications, such as cardiovascular disease and cancer, with 'fluorescent' in vivo biosensors.

26 Jan 2021

New drug screening platform identifies inhibitors of SARS-CoV-2

Researchers in the UK and the United States have developed a stem-cell-based screening platform for identifying compounds that inhibit infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent for coronavirus disease 2019 (COVID-19).

25 Jan 2021

Researchers immunoengineer nanobead system for circulating tumor cell detection

A team of researchers has immunoengineered a nanobead system for the isolation and detection of circulating tumor cells.

21 Jan 2021

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

In an exciting, state-of-the-art study currently available on the medRxiv* preprint server, US researchers created a multi-coronavirus protein microarray containing full-length proteins, peptide libraries, and overlapping protein fragments from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as four other human coronaviruses.

19 Jan 2021

FISH technique can be used to probe sperm DNA for chromosomal defects

Chemotherapy and radiation treatments are known to cause harsh side effects that patients can see or feel throughout their bodies.

19 Jan 2021

Magnetic nanoparticles guide neurite growth in dopaminergic cells

Magnetic nanoparticles raise hopes of treatments for Parkinson’s.

19 Jan 2021

Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

An interesting new preprint research paper that was posted on the bioRxiv* server recently describes the use of rigid monoclonal antibodies (mAbs) in contrast to flexible mAbs, and how this affects the binding of multiple mAbs to the same antigen.

17 Jan 2021

Research reveals new details into how myosin transduces energy

A team of biophysicists from the University of Massachusetts Amherst and Penn State College of Medicine set out to tackle the long-standing question about the nature of force generation by myosin, the molecular motor responsible for muscle contraction and many other cellular processes.

14 Jan 2021

New probes allow scientists to see quadruple-helix DNA in living human cells

New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unravelling its role in cellular processes.

14 Jan 2021

New fluorescence microscopy technique produces nanoscale 3D images of living cells

A new fluorescence microscopy technique has produced the world's first nanoscale 3D images of molecules in a whole, living cell, researchers at KTH Royal Institute of Technology reported.

12 Jan 2021

Naturally selected mutations of SARS-CoV-2 easily duplicated in vitro

In a recent and timely paper, currently available on the bioRxiv preprint server, researchers from Israel and France demonstrated how in vitro evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) follows contagious mutation spread – but can also generate an efficient infection inhibitor.

10 Jan 2021

New test detects SARS-CoV-2 in less than 5 mins

A fast and accurate virus detection strategy is very crucial to reduce the rate of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19. The global scientific research community responded to this unprecedented demand in diagnostic testing by developing several detection platforms, the most sensitive of which detect the viral RNA.

10 Jan 2021

ACE2 receptor is responsible for the wide host range of SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to have a zoonotic origin, perhaps originating in a bat coronavirus with an unknown intermediate host. It is not only very infectious but has been found to infect a wide range of mammals, including dogs, cats, ferrets, hamsters, and minks, besides non-human primates. This range may be still higher, claims a recent preprint that appeared in January 2021 on the bioRxiv server.

6 Jan 2021

Replacing the RNA strand with DNA may enhance efficacy of ASO-based drugs

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide (HDO) model, have demonstrated augmentation of ASO-based drugs by replacing the RNA strand with DNA.

5 Jan 2021

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues.

5 Jan 2021

Novel endoscopic technique improves detection of upper GI tract tumors

Recently there have been significant advances on several fronts in the ongoing war against cancer of the alimentary tract.

5 Jan 2021

Self-learning algorithms can help analyze biological image data

Imaging techniques enable a detailed look inside an organism. But interpreting the data is time-consuming and requires a great deal of experience.

28 Dec 2020

Protein encourages similar developing cells to clump together

Tohoku University scientists have, for the first time, provided experimental evidence that cell stickiness helps them stay sorted within correct compartments during development.

24 Dec 2020

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A new study preprint on the bioRxiv* server demonstrates the ability of a fatty acid synthase inhibitor to improve the survival of mice infected with murine hepatitis virus. In so doing, it adds to the sum of knowledge about the relationship of SARS-CoV-2 with cholesterol metabolism in the host cell.

24 Dec 2020