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New insights on protein degraders open doors to treatment for 'undruggable' diseases

Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' which can be deployed to combat what have previously been regarded as 'undruggable' diseases, including cancers and neurodegenerative diseases.

12 Oct 2024

Evaluating allogeneic transplant for TP53 mutated acute myeloid leukemia

A new editorial was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Transplant or no transplant for TP53 mutated AML."

12 Oct 2024

Research links NK cells to severe cases of RSV in children

Respiratory syncytial virus (RSV) is the leading cause of hospitalization in young children due to respiratory complications such as bronchiolitis and pneumonia.

12 Oct 2024

UCLA study reveals key signs for genetic testing in neurodevelopment disorders

In a new study, UCLA Health researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment disorders.

12 Oct 2024

Researchers uncover mechanism of protein GBP1 in immune defense

The protein GBP1 is a vital component of our body's natural defence against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now.

12 Oct 2024

AI in medical imaging does not guarantee increased efficiency

The use of artificial intelligence (AI) in hospitals and patient care is steadily increasing. Especially in specialist areas with a high proportion of imaging, such as radiology, AI has long been part of everyday clinical practice.

12 Oct 2024

Promising stool test and therapy on the horizon for endometriosis

Promising findings by researchers at Baylor College of Medicine and collaborating institutions could lead to the development of a non-invasive stool test and a new therapy for endometriosis, a painful condition that affects nearly 200 million women worldwide.

12 Oct 2024

Emphasizing workforce diversity in the One Health approach

A new article highlights a critical issue in the One Health approach - an emerging global framework for tackling complex health challenges at the intersection of human, animal, and environmental health.

12 Oct 2024

Abortion emerges as most important election issue for young women, poll finds

Abortion has emerged as the most important issue in the November election for women under 30, according to a survey by KFF — a notable change since late spring, before Vice President Kamala Harris entered the presidential race.

12 Oct 2024

Protein discovery offers insights into bone health and potential treatments for osteoporosis

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

12 Oct 2024

The crucial role of teenage friendships in shaping adult wellbeing

Being a teenager is hard, confusing - and crucially important. Scientists studying teenage socializing have found that teenaged friendships could lay essential foundations for wellbeing in later life, and that not just the kinds of friendships teenagers experience but the timing of those friendships is critical.

12 Oct 2024

New study reveals unique metabolic function of lung-resident NK immune cells

Trinity College Dublin researchers, based at St James's Hospital have provided important insights into the behavior and metabolic function of a previously largely unknown, but crucial 'natural killer' (NK) immune cell resident in the lungs.

12 Oct 2024

Newly identified 'headspin hole' affects breakdancers’ scalp health

Breakdancers may be at risk of developing a condition caused by repeatedly doing a cardinal move of their practice and performance - the headspin - warn doctors in the journal BMJ Case Reports.

12 Oct 2024

Gene editing enhances immunotherapy success by preventing T-cell exhaustion

Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most.

12 Oct 2024

Random cell division promotes healthy embryo growth, says new research

There is variability in when and how cells divide during the development of embryos. While researchers traditionally believed this variability was an obstacle that needed to be regulated, the Hiiragi group now found that it actually promotes healthy development.

12 Oct 2024

Cell stress from crowding leads to slower growth and circular patterns

Like so many organisms on the planet, when cells experience mosh-pit-level crowding, they may just become stressed. Yet unlike most other life forms, cells subject to physical stress from crowding by neighbors can find some relief by dramatically slowing their own growth - and in doing so form an eye-catching pattern of concentric circles as a spectacular consequence.

12 Oct 2024

Study sets new standards for lipidomics in cardiovascular disease research

Results of the first phase of a Ceramide Ring Trial have just been published in the renowned journal Nature Communications, representing a significant landmark in the field of lipidomics.

12 Oct 2024

Breakthrough in mirror molecule synthesis opens doors for drug discovery

A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for potential use against cancer, infection, depression, inflammation and a host of other conditions.

10 Oct 2024

Surge in malaria cases linked to aircraft-transported mosquitoes

Malaria cases resulting from bites of mosquitoes transported by aircraft from areas where is common have increased, according to both a retrospective analysis in France and a systematic review of studies in Europe, which have been published in Eurosurveillance.

10 Oct 2024

Study reveals financial hardships in cancer fundraising campaigns

In a new, large comprehensive analysis led by the American Cancer Society (ACS), researchers, using a form of Artificial Intelligence (AI), found that more than one-third of fundraising stories on the GoFundMe crowdfunding platform in the United States explicitly shared experiences of medical financial hardships and health-related social needs (HRSNs).

10 Oct 2024