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Rare inherited variants shape risk and outcomes in pediatric brain and spinal cord tumors

Researchers at Children's Hospital of Philadelphia (CHOP) and Children's National Hospital in Washington D.C. are uncovering how rare inherited genetic variants contribute to the development of brain and spinal cord tumors in children.

26 Nov 2025

AI model outperforms breast density assessment in breast cancer risk stratification

An image-only artificial intelligence (AI) model for predicting the five-year risk of breast cancer provided stronger and more precise risk stratification than breast density assessment, according to a new study being presented next week at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2025

'Myeloid mimicry' identified as driver of immunotherapy resistance in renal medullary carcinoma

Researchers at The University of Texas MD Anderson Cancer Center have found that renal medullary carcinoma (RMC) cells use an adaptive mechanism called "myeloid mimicry" to hide from the immune system and promote disease hyper progression after immunotherapy, highlighting specific targets that overcome treatment resistance in preclinical models.

25 Nov 2025

Zanidatamab shows durable and meaningful responses in HER2-positive biliary tract cancer

Zanidatamab, a bispecific HER2-targeted antibody, delivered clinically meaningful and durable responses for patients with HER2-positive biliary tract cancer (BTC), according to final results from the HERIZON-BTC-01 clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

25 Nov 2025

Unraveling the mycobiome's role in cancer

A growing body of evidence indicates that the microbiome within the gut and tumors significantly influences cancer initiation, progression, and treatment response.

25 Nov 2025

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to humans.

24 Nov 2025

Calcium-activated switch improves delivery and potency of cancer-fighting drugs

Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too often they don't make it that far.

24 Nov 2025

Discovery reveals role of EGFR in resistance to KRAS inhibitors in pancreatic cancer

A study led by University of Cincinnati Cancer Center researchers sheds new light on how pancreatic cancer cells resist treatment and points to potential new combination therapies to make treatments more effective.

24 Nov 2025

Study introduces cost-effective approach to analyze entire T-cell repertoire

Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children's Research Hospital.

24 Nov 2025

Study reveals biological insights into triple negative breast cancer

Researchers at the LSU LCMC Health Cancer Center have published groundbreaking findings in NPJ Breast Cancer that sheds new light on triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer.

24 Nov 2025

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.

24 Nov 2025

Black cumin: A promising natural agent with potential against chronic diseases

Black cumin seeds contain diverse secondary metabolites, including thymoquinone, flavonoids, triterpenoids and alkaloids, that demonstrate broad antimicrobial, antioxidant, anti-inflammatory and anticancer activity. Early preclinical and limited clinical evidence shows therapeutic potential across chronic diseases, supported by mechanistic and structure activity relationship findings.

24 Nov 2025

Identifying vulnerabilities and new targets for hard-to-treat carcinomas

Some tumors are almost impossible to treat. That's especially true for carcinomas, which don't behave like other malignancies.

24 Nov 2025

Dexamethasone shows potential to fight therapy-resistant breast cancer metastases

The drug dexamethasone supplements cancer treatments to alleviate side effects of chemotherapy such as nausea or inflammation.

24 Nov 2025

Intranasal nanomedicine shows promise against glioblastoma

Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers.

22 Nov 2025

New funding advances AI-powered technology to track therapeutic and diseased cells

Targeting and treating diseases first requires being able to find specific cells-which is challenging because they travel within the body and can "hide."

21 Nov 2025

Marine bacterium shows powerful therapeutic effects against colorectal cancer

A research team led by Professor Eijiro Miyako at the Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), has discovered that the marine bacterium Photobacterium angustum demonstrates remarkable therapeutic efficacy against colorectal cancer.

21 Nov 2025

Global collaboration accelerates progress toward eliminating cervical cancer

Cervical cancer will be the first human cancer eliminated through coordinated global action. A new special issue of Cancer Biology & Medicine brings together leading experts from around the world to examine progress, challenges, and innovations in prevention, screening, and treatment.

21 Nov 2025

After series of denials, his insurer approved doctor-recommended cancer care. It was too late.

For nearly three years, Eric Tennant endured chemotherapy infusions, rounds of radiation, biopsies, and hospitalizations that left him weak and depleted.

21 Nov 2025

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Tumor News and Research

Rare inherited variants shape risk and outcomes in pediatric brain and spinal cord tumors

AI model outperforms breast density assessment in breast cancer risk stratification

'Myeloid mimicry' identified as driver of immunotherapy resistance in renal medullary carcinoma

Zanidatamab shows durable and meaningful responses in HER2-positive biliary tract cancer

Unraveling the mycobiome's role in cancer

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

Calcium-activated switch improves delivery and potency of cancer-fighting drugs

Discovery reveals role of EGFR in resistance to KRAS inhibitors in pancreatic cancer

Study introduces cost-effective approach to analyze entire T-cell repertoire

Study reveals biological insights into triple negative breast cancer

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

Black cumin: A promising natural agent with potential against chronic diseases

Identifying vulnerabilities and new targets for hard-to-treat carcinomas

Dexamethasone shows potential to fight therapy-resistant breast cancer metastases

Intranasal nanomedicine shows promise against glioblastoma

New funding advances AI-powered technology to track therapeutic and diseased cells

Marine bacterium shows powerful therapeutic effects against colorectal cancer

Global collaboration accelerates progress toward eliminating cervical cancer

After series of denials, his insurer approved doctor-recommended cancer care. It was too late.

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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