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More new SARS-CoV-2 variants are highly likely

In a recent report posted to the bioRxiv preprint server, researchers from the United Kingdom and Uganda reveal unique protein features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to other representatives of Sarbecoviruses.

8 Apr 2021

Leaky gut and microbial dysbiosis could contribute to cytokine storm in severely ill COVID-19 cases

The gut is a well-established route of infection and target for viral damage by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19. This is supported by the clinical observation that about half of COVID-19 patients exhibit gastrointestinal (GI) symptoms.

8 Apr 2021

The interaction between blood clotting and SARS-CoV-2 infection

Coagulopathy - a condition in which the blood's ability to clot is impaired, is recognized as a significant aspect of morbidity in COVID-19 patients. In a recent study, Prof Lewis Cantley and a team of researchers explored the role of coagulation factors in the SARS-CoV-2 infection. Their recent study is posted on the bioRxiv server.

7 Apr 2021

New bioprinting process uses ultrashort peptides to print hydrogel scaffolds

A new automated process prints a peptide-based hydrogel scaffold containing uniformly distributed cells. The scaffolds hold their shapes well and successfully facilitate cell growth that lasts for weeks.

5 Apr 2021

Study uncovers novel mechanism in rare mutation associated with Alzheimer's

A novel mechanism has been identified that might explain why a rare mutation is associated with familial Alzheimer's disease in a new study by investigators at the University of Chicago.

3 Apr 2021

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

There have been concerns that several SARS-CoV-2 variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from the B.1.351 variant, CD8+ T cells showed a broad response to all SARS-CoV-2 variants.

2 Apr 2021

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies

A new research paper published in the Biophysical Journal describes a novel binding pocket used by a viral non-structural protein (nsp) to form an activated complex with its partner nsp. In so doing, it may have revealed a common target that may be useful in the development of a broad-spectrum antiviral drug against all coronaviruses.

1 Apr 2021

Development of a model of substrate coordination to Zn-bound ACE2

The ongoing coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has claimed more than 2.8 million lives worldwide. Authorities are facing difficulty in preventing the spread of disease due to the highly infectious nature of SARS-CoV-2. Therefore, reducing the virus's ability to infect an individual's respiratory epithelial cells could prove an effective measure to prevent disease transmission.

31 Mar 2021

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

Twins may look alike on the outside, but not so much on the inside. That's one takeaway from a new preprint study posted to the medRxiv server where Brazilian researchers observed different T-cell responses in two pairs of identical twins exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One twin who was reinfected with SARS-CoV-2 four months after had low recognition of CD4+ and CD8+ T-cell epitopes.

31 Mar 2021

Imported COVID-19 cases responsible for spread of the UK and Brazil SARS-CoV-2 variants in Italy

A new study examines a major consequence of the second wave of COVID-19 infection—namely, the rapid emergence of new viral lineages and variants.

30 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

The scientific consensus is that safe and highly effective vaccines are required to end the ongoing pandemic of coronavirus disease 2019 COVID-19, caused by SARS-CoV-2. A new study describes a new vaccine that presents two viral antigens to the human immune system, in order to elicit a more efficacious response.

25 Mar 2021

Could an mRNA vaccine second dose reduce cellular immunity in previously infected individuals?

A new study, which was released on the bioRxiv* preprint server, shows the differential effect that a standard vaccine protocol may have on individuals, based on their history of prior infection with the virus.

25 Mar 2021

Researcher to use new approach to explore brain proteins and their potential to cure mental diseases

Dr. Hans Maric has received one of the German Research Foundation's highly prestigious Emmy Noether awards, worth around 1.7 million euros.

25 Mar 2021

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

Despite continued improvements in antibiotics and hospital intensive care, staph sepsis - a bloodstream infection caused by Staphylococcus aureus bacteria - still causes severe illness or death in 20 to 30 percent of patients who contract it.

24 Mar 2021

New compound may provide a basis for drug development against COVID-19

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, arrived one year ago and turned our lives upside-down.

24 Mar 2021

Epitope antibody testing is effective in detecting immune responses to SARS-CoV-2

A new preprint study led by Shawn S-C. Li from Western University in Ontario, Canada, provides evidence of epitope-specific antibody responses and designed a test to measure this in relation to disease severity and outcome after infection.

24 Mar 2021

Review: Using biomaterials in dental implants

Announcing a new article publication for BIO Integration journal. In this review article the authors Oliver K. Semisch-Dieter, Andy H. Choi and Martin P. Stewart from the University of Technology Sydney, Ultimo, NSW, Australia discuss the use of biomaterials in dental implants.

22 Mar 2021

Bacteria residing within tumor cells can boost cancer immunotherapy

Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells.

22 Mar 2021

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

Co-founded back in 2014 by VHIO's Laura Soucek, CEO of the enterprise, and Marie-Eve Beaulieu, Chief Scientific Officer (CSO) of the company, VHIO-born spin-off Peptomyc S.L. has just announced that it has received approval from the Spanish Agency of Medicines and Medical Devices for conducting clinical trials in Spain (AEMPS), to initiate the first-in-human Phase I/II clinical trial with its first compound - a disruptive Myc inhibitor, Omomyc (OMO-103).

19 Mar 2021

Peptides News and Research

More new SARS-CoV-2 variants are highly likely

Leaky gut and microbial dysbiosis could contribute to cytokine storm in severely ill COVID-19 cases

The interaction between blood clotting and SARS-CoV-2 infection

New bioprinting process uses ultrashort peptides to print hydrogel scaffolds

Study uncovers novel mechanism in rare mutation associated with Alzheimer's

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies

Development of a model of substrate coordination to Zn-bound ACE2

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

Imported COVID-19 cases responsible for spread of the UK and Brazil SARS-CoV-2 variants in Italy

Linear epitope mapping of the SARS-CoV-2 spike protein

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

Could an mRNA vaccine second dose reduce cellular immunity in previously infected individuals?

Researcher to use new approach to explore brain proteins and their potential to cure mental diseases

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

New compound may provide a basis for drug development against COVID-19

Epitope antibody testing is effective in detecting immune responses to SARS-CoV-2

Review: Using biomaterials in dental implants

Bacteria residing within tumor cells can boost cancer immunotherapy

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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