Antigen News and Research

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Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

The University of Texas MD Anderson Cancer Center and Replay today announced that the Food & Drug Administration (FDA) has issued a 'safe to proceed' for the Investigational New Drug (IND) application for NY-ESO-1 TCR/IL-15 NK, an engineered T cell receptor natural killer (TCR NK) cell therapy for advanced synovial sarcoma and myxoid/round cell liposarcoma.

20 Jun 2023

‘Break the Silence’ campaign urges British fathers to discuss men's health issues with their sons

Men are often reluctant to talk about health matters, and that’s certainly true according to new research by GenesisCare, which reveals that nearly half (49%) of fathers admit they steer clear of talking about men’s health issues with their sons - because they don’t want to scare them (19%).

19 Jun 2023

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Researchers reported on the contribution of trained immune responses to protection against SARS-CoV-2 infections and future pandemics.

16 Jun 2023

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

Researchers evaluated the prophylactic immune protection conferred by a single intramuscular injection of adintrevimab (ADG20) against symptomatic COVID-19.

16 Jun 2023

From COVID-19 to future threats: building a global genomic surveillance network

Researchers present a modular framework for global sustainable networks of viral genomic surveillance.

16 Jun 2023

Substance P neuropeptides' role in post-COVID-19 conditions suggested in recent study

Scientists review available evidence on the association between post-COVID-19 conditions and tachykinins.

15 Jun 2023

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

15 Jun 2023

Stronger defense: symptomatic malaria provides durable protection against reinfection

Researchers evaluated the immune protection conferred by symptomatic and asymptomatic P. falciparum.

14 Jun 2023

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

13 Jun 2023

Researchers explore viral emissions in a phase 1, open label, first-in-human SARS-CoV-2 experimental infection study

Researchers explored the release of viral particles into the environment and air after SARS-CoV-2 human challenge.

13 Jun 2023

Helicobacter pylori infection found to lower cognition among adults in the UK

Researchers evaluated the association between Helicobacter pylori and cognition.

9 Jun 2023

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

The study reveals that MIS-C patients, post SARS-CoV-2 infection, develop a unique immune response against the virus' N protein, indicating a cross-reactivity with the self-protein SNX8, which might link the infection to the ensuing inflammatory syndrome.

8 Jun 2023

Scientists unlock virus-fighting power with synthetic nanobody platform

Discovery and validation of nanobodies, a promising class of biologics, for viral infection prevention and treatment, including anti-SARS-CoV-2 nanobodies with enhanced neutralization properties through synergistic pairing. The study demonstrates the potential of nanobodies in developing effective therapies against viral infections.

8 Jun 2023

Differences in tumor mutation burden are a major reason for divergence: Study

The expected course of a patient's cancer prognosis has traditionally been judged by its type, stage and microscopic aggressiveness, but patients with the same presentation can still have widely divergent outcomes. Researchers from Vanderbilt-Ingram Cancer Center have discovered that differences in tumor mutation burden are a major reason for this divergence.

7 Jun 2023

Two studies seek to understand the drivers of chronic and progressive phase of COVID-19

Early studies of COVID-19 focused on the acute phase of the disease. However, attention has now turned to the long-term consequences of the disease, which are also significant causes of morbidity and mortality.

6 Jun 2023

Breakthrough: Sequencing functional antibody proteins directly from human blood

Rapid Novor Inc., the world’s leader in mass spectrometry (MS)-based antibody protein sequencing, announced today that its REpAb® antibody discovery platform was used to successfully sequence a complex mixture of functional antibodies directly from the serum of a human patient after receiving a COVID-19 vaccine.

6 Jun 2023

Experts investigate the correlation between BORIS mutations and protein expression

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression."

6 Jun 2023

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

5 Jun 2023

American Indian and Alaska Native men less likely to be screened for prostate cancer, study shows

New research from Wake Forest University School of Medicine shows that American Indian and Alaska Native men are less likely to be screened for prostate cancer compared to other racial/ethnic groups.

5 Jun 2023

Improving prostate cancer screening: accounting for genetic determinants of PSA variation

Researchers conducted a genome-wide analysis of prostate-specific antigen (PSA) levels of men without prostate cancer.

5 Jun 2023

Antigen News and Research

Phase I clinical study of TCR NK cell therapy for sarcoma expected to commence later this year

‘Break the Silence’ campaign urges British fathers to discuss men's health issues with their sons

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

From COVID-19 to future threats: building a global genomic surveillance network

Substance P neuropeptides' role in post-COVID-19 conditions suggested in recent study

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Stronger defense: symptomatic malaria provides durable protection against reinfection

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Researchers explore viral emissions in a phase 1, open label, first-in-human SARS-CoV-2 experimental infection study

Helicobacter pylori infection found to lower cognition among adults in the UK

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

Scientists unlock virus-fighting power with synthetic nanobody platform

Differences in tumor mutation burden are a major reason for divergence: Study

Two studies seek to understand the drivers of chronic and progressive phase of COVID-19

Breakthrough: Sequencing functional antibody proteins directly from human blood

Experts investigate the correlation between BORIS mutations and protein expression

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

American Indian and Alaska Native men less likely to be screened for prostate cancer, study shows

Improving prostate cancer screening: accounting for genetic determinants of PSA variation

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