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Biocompatible photooxygenation catalyst could be potentially used to treat amyloid diseases

A new, biocompatible photooxygenation catalyst that can selectively oxygenate and degrade the pathogenic aggregation of Alzheimer's disease (AD)-related amyloid-β peptide (Aβ) under near-infrared (NIR) light irradiation is developed.

25 Nov 2020

Researchers use fluorescent nanosensors to track down bacteria

Researchers from Bochum, Göttingen, Duisburg and Cologne have developed a new method for detecting bacteria and infections.

25 Nov 2020

Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical samples

In a recent medRxiv* preprint paper, researchers from the University of Connecticut Health Center in the United States unveil their digital warm-start CRISPR (WS-CRISPR) method for stringent and sensitive quantitative detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples of patients with coronavirus disease (COVID-19).

24 Nov 2020

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Researchers have developed a fluorescent reporter gene-bearing recombinant form of SARS-CoV-2, which is capable of replication.

23 Nov 2020

Sage and perilla herbal teas could help to prevent or treat COVID-19

Researchers in Germany have conducted a study demonstrating the potential antiviral effects of commonly consumed herbal teas on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the pathogen that causes coronavirus disease 2019 (COVID-19).

22 Nov 2020

Chemists discover effective inhibitors to block SARS-CoV-2

Some viruses can get inside cells via a mechanism that involves sulfur organic molecules. Chemists at UNIGE have discovered effective inhibitors and blocked the uptake of SARS-CoV-2.

20 Nov 2020

Drinking hot beverages from paper cups poses health risks, shows study

Drinking hot beverages from paper cups poses health risks, a study has found.

19 Nov 2020

Raman microscopy-based approach uses gold nanoparticles for visualizing small-molecule drugs

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

18 Nov 2020

CMU researchers develop new technique for isolating brain cells associated with Parkinson's disease

Carnegie Mellon University researchers have developed a new technique for isolating a type of brain cell associated with Parkinson's disease symptoms, enabling them to study that cell type in detail.

16 Nov 2020

Tomocube’s HT-2 microscope quantifies therapeutic effects of targeted nanodrugs against atherosclerosis

Treatment of Atherosclerosis, the disease responsible for approximately half of all deaths in westernized societies, is a step closer following correlative studies using Tomocube’s HT-2 microscope.

From Tomocube Inc. 16 Nov 2020

Imaging technique reveals opioid receptor localization across the whole brain

Winding and twisting like a labyrinth, the brain consists of an elaborate network of passages through which information flows at high speeds, rapidly generating thoughts, emotions, and physical responses.

12 Nov 2020

Researchers identify acrylamides that inhibit SARS-CoV-2 main protease

A new study in the preprint server bioRxiv published in November 2020 describes the discovery of acrylamide fragments that can effectively disable key enzymes in both the hand, foot and mouth virus and SARS-CoV-2 virus.

11 Nov 2020

Semi-automated approach accelerates artificial organoid growth and selection

The method currently used to produce stem cell-derived tissues has a very limited throughput. By semi-automating tissue differentiation, researchers from MIPT and Harvard have made the process nearly four times faster, without compromising on quality.

10 Nov 2020

Novel, highly specific treatment method for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine.

9 Nov 2020

A digital CRISPR-based method for quick detection and absolute quantification of SARS-CoV-2

In a recent medRxiv* preprint manuscript, researchers from Singapore and the United States report the development of a digital CRISPR method for the sensitive, specific, and rapid detection of viral nucleic acids at a constant temperature, which could be exploited for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Nov 2020

Super-resolution images of functioning and pathologically altered nerve cells

Three experts for super-resolution microscopy jointly want to obtain better images of functioning and pathologically altered nerve cells. The European Research Council ERC is funding them with eleven million euros.

5 Nov 2020

Scientists pin down a brain area crucial for predicting the consequences of choices

Predicting the outcomes of actions in order to make good decisions is a critical role of brain function. This process is thought to work through two fundamentally different mechanisms called "model-free" and "model-based" learning.

4 Nov 2020

Machine-learning algorithm helps sort out huge amounts of data for protein research

Sorting huge amounts of data is a bottleneck in protein research, a field that is crucial to make use of the gene-editing technology CRISPR and fully understand diseases like cancer, Alzheimer's and Parkinson's

3 Nov 2020

Study finds new clues for disarming antibiotic-resistant bacteria

A virus can stop bacteria from sharing genes for antibiotic resistance among themselves, Texas A&M AgriLife researchers have discovered. The results hint at new ways to treat infections and describe a new feature of a highly diverse, largely unexplored part of the biosphere.

3 Nov 2020

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Now, researchers from the University of California, San Francisco, and Stanford University, California, USA, reported a safe and potent antiseptic for use in humans named ethacridine, which effectively inhibits SARS-CoV-2 even at very low concentrations of EC50 ~ 0.08 µM. Their work has is published on the preprint server bioRxiv*.

1 Nov 2020