Immune System News and Research

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FDA-approved drug improves clinical outcomes among patients with rare immunologic disease

Adding the injectable drug mepolizumab to standard treatment for eosinophilic granulomatosis with polyangiitis (EGPA), a rare immunologic disease, significantly improved clinical outcomes among participants in an advanced clinical trial, scientists report.

18 May 2017

Researchers show how cancer therapy works in different way to destroy tumor cells

Antibodies to the proteins PD-1 and PD-L1 have been shown to fight cancer by unleashing the body's T cells, a type of immune cell.

18 May 2017

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

18 May 2017

Tumor mutation load in patient's biopsy varies by age and type of cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors.

18 May 2017

Microbes can manipulate molecular machinery of host cells to influence health

All animals -- from sea sponges to modern-day humans -- evolved in a world already teeming with microbes. These single-celled microorganisms now cover practically every surface of our bodies and are as much a part of our biology as our own tissues and organs.

17 May 2017

Researchers develop new strategy that can revolutionize HIV vaccine design

Vaccines are an essential tool for preventing and treating serious infectious diseases such as polio, chicken pox and measles. But so far it has not been possible to develop vaccines capable of contributing to the treatment and prevention of chronic infectious diseases such as HIV and hepatitis C.

17 May 2017

Researchers develop new test for rapid and reliable diagnosis of sepsis

Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.

17 May 2017

Experimental gene therapy proven safe for preserving vision of people with AMD

In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it may be effective in preserving the vision of people with wet age-related macular degeneration.

17 May 2017

Major allergens strongly underrepresented in some immunotherapy against bee stings

Summer is approaching, and for many allergy sufferers this means it is time to start fearing bee stings. "Allergic reactions to insect venoms are potentially life-threatening, and constitute one of the most severe hypersensitivity reactions," explains PD Dr. Simon Blank, research group leader at the Center of Allergy & Environment, a joint undertaking by the Helmholtz Zentrum München and the TUM.

17 May 2017

Scientists unravel mystery of T cell signaling process vital to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained a mystery.

16 May 2017

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

Analysis of a patient's gut microbiome - the microbial population of the gastrointestinal tract - may be able to predict the likelihood of successful treatment for inflammatory bowel disease with biologic drugs that target immune system activity.

16 May 2017

IBM scientists identify new way to trigger the body's immune response to fight diseases

IBM announced its researchers have identified a new way to trigger the body's immune response by using polymer-coated graphene sheets. The research was recently published in Nature Communications.

16 May 2017

Study provides insights into how HCMV infection causes birth defects

Fresh insights into how a common virus replicates could pave the way for new therapies to stop its spread.

15 May 2017

Scientists discover simple way to use light for steering killer immune cells toward tumors

The science behind harnessing the immune system to fight cancer is complicated, but a University of Rochester Medical Center laboratory discovered a simple, practical way to use light and optics to steer killer immune cells toward tumors.

15 May 2017

Scientists uncover potential strategy to shock and kill HIV virus

Scientists at the Gladstone Institutes discovered that an enzyme called SMYD2 could be a new therapeutic target for flushing out the HIV that hides in infected individuals. Overcoming this latent virus remains the most significant obstacle to a cure.

15 May 2017

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

A University of Manchester test on the mucus lining of the intestine, performed in mice, has found changes in bacteria that could lead to inflammatory bowel disease 12 weeks earlier than previously possible through looking at stool samples, leading to the possibility of earlier diagnosis and better management of the disease in humans.

From The University of Manchester 15 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Immune System News and Research

FDA-approved drug improves clinical outcomes among patients with rare immunologic disease

Researchers show how cancer therapy works in different way to destroy tumor cells

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Tumor mutation load in patient's biopsy varies by age and type of cancer

Microbes can manipulate molecular machinery of host cells to influence health

Researchers develop new strategy that can revolutionize HIV vaccine design

Researchers develop new test for rapid and reliable diagnosis of sepsis

Experimental gene therapy proven safe for preserving vision of people with AMD

Major allergens strongly underrepresented in some immunotherapy against bee stings

Scientists unravel mystery of T cell signaling process vital to immune response

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

IBM scientists identify new way to trigger the body's immune response to fight diseases

Study provides insights into how HCMV infection causes birth defects

Scientists discover simple way to use light for steering killer immune cells toward tumors

Scientists uncover potential strategy to shock and kill HIV virus

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Scientists reveal how immune cells activate to kill parasitic worms

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