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Researchers develop computer program to find new indications for old drugs

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs.

16 Nov 2017

One in 20 children still receiving codeine to treat pain despite warning from federal regulators

A new study shows as many as one in 20 children were still receiving codeine to treat pain after tonsil and adenoid surgery, two years after federal regulators warned doctors that prescribing the opioid to kids after the routine surgeries could be fatal.

16 Nov 2017

New discovery may lead to natural products for preventing dental caries

A new discovery may one day lead to natural anticavity products, researchers report. The scientists from West China School of Stomatology and Academic Centre for Dentistry Amsterdam have figured out the main active ingredient of Galla Chinensis, a natural herb, and further improved its anti-caries efficacy. The finding is published in The Open Dentistry Journal.

16 Nov 2017

New oxytocin chemical sensor could be first step towards early diagnosis of autism

Is it going to be possible to detect features of autism at birth? At the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw a sensor has come into being that means this may become a reality.

16 Nov 2017

FDA approves drug to treat pediatric, adult patients with rare Sly syndrome

The U.S. Food and Drug Administration today approved Mepsevii (vestronidase alfa-vjbk) to treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. MPS VII is an extremely rare, progressive condition that affects most tissues and organs.

15 Nov 2017

Study identifies molecular pathway critical to development of fibrosis

A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis - scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs.

15 Nov 2017

ATS and JRS publish new guidelines for diagnosis and management of LAM

The American Thoracic Society and the Japanese Respiratory Society have published additional clinical practice guidelines regarding four specific questions related to the diagnosis of lymphangioleiomyomatosis (LAM) and management of pneumothoraces in patients with LAM.

15 Nov 2017

Nanowires could be potential drug delivery tools for neurodegenerative diseases

Millions of Americans suffer from neurodegenerative diseases such as Alzheimer's and Parkinson's. Researchers have identified promising new treatments, such as cerebrolysin, but current clinical approaches are ineffective because critical concentrations of the drug dissipate within the body before reaching the blood-brain barrier and central nervous system.

15 Nov 2017

Chronic preconception exposure to genistein may adversely affect female fertility, mice study finds

Exposure to the phytoestrogen genistein prior to conception may adversely affect female fertility and pregnancy outcomes, depending on the dosage and duration of exposure, a new study in mice suggests.

14 Nov 2017

Analysis finds simple method to identify patients most likely to benefit from long-term canakinumab treatment

A new analysis seeks to answer the question of which patients are likely to gain the greatest cardiovascular benefit when treated with the anti-inflammatory agent canakinumab.

14 Nov 2017

PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease

Patients with peripheral artery disease (PAD) are at high risk of heart attack, stroke and cardiovascular death. In addition, PAD patients can suffer major adverse limb events, such as acute limb ischemia - the equivalent of a heart attack in the leg - that can lead to limb loss.

14 Nov 2017

Standard technique for removing extra fingers often prone to painful complications

Polydactyly, or having an extra finger, is fairly common, occurring in 1 in every 1,000 people--among African-Americans, 1 in 150. Children with supernumerary digits are usually treated within the first months of infancy.

13 Nov 2017

Researchers identify 'strategies' used by bacteria to protect themselves from antibiotics

Antibiotic resistance happens when bacteria evolve mechanisms to withstand the drugs which are used to treat infections.

13 Nov 2017

Leading organizations call for responsible use of antibiotics to combat rising drug resistance

In the lead-up to World Antibiotic Awareness Week (13-19 November 2017), the Food and Agriculture Organization of the United Nations, the World Health Organization and the World Organisation for Animal Health are together calling for responsible use of antibiotics in humans and animals to reduce the emergence of antibiotic resistance.

13 Nov 2017

Study identifies novel mechanism by which tumors can resist cancer immunotherapy

A Ludwig Cancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunotherapy.

10 Nov 2017

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

10 Nov 2017

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Celgene Corporation recently announced results from two phase 3 trials evaluating the efficacy and safety of the drug ozanimod.

10 Nov 2017

Antiviral drug selectively targets the most aggressive viruses, research says

An antiviral drug that inhibits a virus' replication machinery selectively targets the most aggressive viruses, according to new research that looked at the infection of individual cells by a virus and the consequence of antiviral intervention.

9 Nov 2017

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

By connecting highly effective cancer immunotherapy drugs such as anti-CTLA4 (ipilimumab) and anti-PD-L1 (atezolizumab) to peptides that bind to tissues in and around tumors, a research team based at the University of Chicago found a way to improve the drugs' impact while limiting treatment-related side effects.

9 Nov 2017

Scientists uncover mechanism that prevents tumor growth in melanoma

Natural Killer (NK) cells, lymphocytes of the innate immune system with strong cytotoxic activity, play a major role in the immune response against tumors.

8 Nov 2017

Efficacy News and Research

Researchers develop computer program to find new indications for old drugs

One in 20 children still receiving codeine to treat pain despite warning from federal regulators

New discovery may lead to natural products for preventing dental caries

New oxytocin chemical sensor could be first step towards early diagnosis of autism

FDA approves drug to treat pediatric, adult patients with rare Sly syndrome

Study identifies molecular pathway critical to development of fibrosis

ATS and JRS publish new guidelines for diagnosis and management of LAM

Nanowires could be potential drug delivery tools for neurodegenerative diseases

Chronic preconception exposure to genistein may adversely affect female fertility, mice study finds

Analysis finds simple method to identify patients most likely to benefit from long-term canakinumab treatment

PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease

Standard technique for removing extra fingers often prone to painful complications

Researchers identify 'strategies' used by bacteria to protect themselves from antibiotics

Leading organizations call for responsible use of antibiotics to combat rising drug resistance

Study identifies novel mechanism by which tumors can resist cancer immunotherapy

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Antiviral drug selectively targets the most aggressive viruses, research says

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

Scientists uncover mechanism that prevents tumor growth in melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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