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Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

Cadmium linked to DNA damage and morphological changes caused by particulate matter

Particulate matter causes health problems for those who inhale the fine droplets and particles, but the chemical composition of the mixture matters - and can vary widely across space and time.

28 Dec 2023

Study reveals how tiny tweaks to actin shape our cells

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin.

22 Dec 2023

Researchers produce artificial cells with potential for drug delivery and tissue engineering

Artificial cells, made with the use of synthetic materials, have been produced in international research led at the University of Strathclyde.

11 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Key role of ion and water influx in T cell migration uncovered

Research reveals that T cell migration relies on ion and water influx for actin polymerization and movement, with the WNK1 kinase playing a critical role in regulating these processes, offering new insights into adaptive immunity.

10 Dec 2023

New genetic links to coronary artery calcification uncovered, offering treatment insights

A study in Nature Cardiovascular Research identifies two new genetic loci associated with coronary artery calcification (CAC), a key indicator of atherosclerosis and coronary artery disease.

5 Dec 2023

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

Discovery of a novel cardiac-specific myosin modulator.

28 Nov 2023

Researchers discover new option to target the metastatic capacity of melanoma cells

As an extremely aggressive form of skin cancer, cutaneous melanoma is still associated with a high mortality rate. Enormous progress has recently been made in the fight against deadly metastasis, but existing therapeutic measures are still not effective in many cases.

21 Nov 2023

Microglia found to play crucial role in early human brain development

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development.

14 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

How one gene shakes up our understanding of male infertility

The study investigates the role of the ACTL7B gene in sperm formation using genetically modified mice and finds that deficiencies in this gene lead to failed spermatogenesis and structural sperm abnormalities. Given the gene's similarity in humans, the findings suggest ACTL7B could serve as a potential biomarker for male infertility.

31 Oct 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

How chromatin compartmentalization affects DNA damage response

Researchers uncover novel insights into how chromatin compartmentalization influences the DNA damage response (DDR) after double-stranded breaks (DSBs), shedding light on the mechanisms behind genomic integrity maintenance and the risk of translocations. Their findings reveal the importance of chromosomal design in DNA repair and the potential implications for genome stability and cancer translocations.

22 Oct 2023

Can human chorionic gonadotropin supplements enhance penile growth?

Whether human chorionic gonadotropin could expedite tunica albuginea restructuring to aid penile development.

4 Oct 2023

Study discovers a new endocytic pathway in budding yeast

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients.

25 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Study explores the role of sex on mRNA and protein levels and its genetic regulation in brain

Researchers investigated the impact of biological sex on protein levels and its genomic control by analyzing 1,277 proteomes of the brain.

4 Sep 2023