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Single-dose oral cholera vaccine shows promising results in early clinical trial

Clinical trial shows promising results for PanChol, a single-dose oral vaccine aimed at the up to 4 million annual cholera cases worldwide.

7 Jan 2026

Economic instability linked to higher risk of long COVID in children

New research led by Mass General Brigham investigators suggests that long COVID is more prevalent in school-aged children and adolescents who experience economic instability and adverse social conditions.

5 Jan 2026

Artificial intelligence improves risk stratification in oropharyngeal cancer

A team led by investigators at Mass General Brigham and Dana-Farber Cancer Institute has developed and validated an artificial intelligence (AI)–based noninvasive tool that can predict the likelihood that a patient's oropharyngeal cancer-a type of head and neck cancer that develops in the throat-will spread, thereby signaling which patients should receive aggressive treatment.

23 Dec 2025

Early brain connectivity predicts recovery after traumatic brain injury

After traumatic brain injury (TBI), some patients may recover completely, while others retain severe disabilities.

22 Dec 2025

Rethinking Mendelian assumptions in inherited retinal degenerations

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

22 Dec 2025

Study finds Brain Care Score as a strong predictor of stroke across racial groups

A new study from Mass General Brigham found the Brain Care Score (BCS) is a strong predictor of stroke across different racial groups in the U.S.

18 Dec 2025

Stress may help explain why patients with depression are at higher risk of cardiovascular disease

Patients with depression are at higher risk of cardiovascular disease, and a new study suggests that stress may help explain why.

17 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors and clinical course, and underscoring the importance of early diagnosis and treatment.

12 Dec 2025

Early relapse predicts poor survival in mature nodal T-cell lymphoma

Mature nodal T-cell lymphoma is a type of rare and aggressive blood cancer. Limited data make it difficult to identify high-risk patients or tailor treatment strategies, so most patients receive similar care despite differences in disease characteristics and outcomes.

12 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

They need a ventilator to stay alive. Getting one can be a nightmare.

On vacation in Mexico last year, Michael DiPlacido passed out twice while scuba diving and again in his hotel. Back in St. Louis, doctors diagnosed him with amyotrophic lateral sclerosis, or ALS, an incurable disease that often requires mechanical ventilation.

2 Dec 2025

Killer T cell traits explain why some people achieve long-term HIV remission after treatment

Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV medications and maintain control of the virus for years, while others given the same treatment do not achieve this remission.

1 Dec 2025

Hospital-level care at home found to be feasible for rural patients with acute conditions

One in five people in the United States live in a rural area. Patients in rural communities often struggle to access care because of travel difficulties, high costs and limited resources, leading to worse medical outcomes.

1 Dec 2025

Social support plays an important role in health and well-being of older adults

Two recent studies from the University of Eastern Finland show that social support plays an important role in health and well-being in later life. Having access to adequate social support is associated with longevity among older adults, and with better quality of life among home care recipients.

27 Nov 2025

Experimental drug engasertib shows promise for treating inherited bleeding disorder

Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting 1 in 3,800 persons.

26 Nov 2025

Most public speakers at FDA advisory committees support drug approval

U.S. Food and Drug Administration (FDA) advisory committees play a key role in evaluating the efficacy and safety of new drugs.

25 Nov 2025

Climate extremes continue to drive preventable deaths across the United States

Researchers led by investigators at Mass General Brigham have discovered that over the last 25 years, heat and cold-related deaths have caused more than 69,000 deaths in the U.S., disproportionately affecting certain populations. The findings are published in the Annals of Internal Medicine.

18 Nov 2025

Ultra-processed foods linked to precursors of early-onset colorectal cancer

Colorectal cancer used to be associated with old age, but diagnoses have become increasingly common in adults aged 50 or younger particularly in high-income countries like the United States.

13 Nov 2025

Home Care News and Research

Single-dose oral cholera vaccine shows promising results in early clinical trial

Economic instability linked to higher risk of long COVID in children

Artificial intelligence improves risk stratification in oropharyngeal cancer

Early brain connectivity predicts recovery after traumatic brain injury

Rethinking Mendelian assumptions in inherited retinal degenerations

Study finds Brain Care Score as a strong predictor of stroke across racial groups

Stress may help explain why patients with depression are at higher risk of cardiovascular disease

Hyperphosphorylated tau may help protect the brain from infection

Immune checkpoint inhibitors can trigger rare immune thrombocytopenia in cancer patients

Early relapse predicts poor survival in mature nodal T-cell lymphoma

Mass General Brigham launches AI company to enhance clinical trial matching

Engineered herpes virus activates potent immune responses against glioblastoma

They need a ventilator to stay alive. Getting one can be a nightmare.

Killer T cell traits explain why some people achieve long-term HIV remission after treatment

Hospital-level care at home found to be feasible for rural patients with acute conditions

Social support plays an important role in health and well-being of older adults

Experimental drug engasertib shows promise for treating inherited bleeding disorder

Most public speakers at FDA advisory committees support drug approval

Climate extremes continue to drive preventable deaths across the United States

Ultra-processed foods linked to precursors of early-onset colorectal cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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