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Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

They need a ventilator to stay alive. Getting one can be a nightmare.

On vacation in Mexico last year, Michael DiPlacido passed out twice while scuba diving and again in his hotel. Back in St. Louis, doctors diagnosed him with amyotrophic lateral sclerosis, or ALS, an incurable disease that often requires mechanical ventilation.

2 Dec 2025

Killer T cell traits explain why some people achieve long-term HIV remission after treatment

Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV medications and maintain control of the virus for years, while others given the same treatment do not achieve this remission.

1 Dec 2025

Hospital-level care at home found to be feasible for rural patients with acute conditions

One in five people in the United States live in a rural area. Patients in rural communities often struggle to access care because of travel difficulties, high costs and limited resources, leading to worse medical outcomes.

1 Dec 2025

Social support plays an important role in health and well-being of older adults

Two recent studies from the University of Eastern Finland show that social support plays an important role in health and well-being in later life. Having access to adequate social support is associated with longevity among older adults, and with better quality of life among home care recipients.

27 Nov 2025

Experimental drug engasertib shows promise for treating inherited bleeding disorder

Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting 1 in 3,800 persons.

26 Nov 2025

Most public speakers at FDA advisory committees support drug approval

U.S. Food and Drug Administration (FDA) advisory committees play a key role in evaluating the efficacy and safety of new drugs.

25 Nov 2025

Climate extremes continue to drive preventable deaths across the United States

Researchers led by investigators at Mass General Brigham have discovered that over the last 25 years, heat and cold-related deaths have caused more than 69,000 deaths in the U.S., disproportionately affecting certain populations. The findings are published in the Annals of Internal Medicine.

18 Nov 2025

Ultra-processed foods linked to precursors of early-onset colorectal cancer

Colorectal cancer used to be associated with old age, but diagnoses have become increasingly common in adults aged 50 or younger particularly in high-income countries like the United States.

13 Nov 2025

Triglyceride-lowering drug can also decrease the risk of acute pancreatitis

Researchers from Mass General Brigham have found that olezarsen-a drug designed to lower triglyceride levels-can also decrease the risk of acute pancreatitis, a potential complication in patients with severely elevated triglyceride levels.

10 Nov 2025

Who is willing to trust home-care robots in Japan?

Research in Japan shows that openness and trust are key to accepting home-care robots, impacting willingness to share personal data for development purposes.

7 Nov 2025

Heavy drinking linked to earlier and more severe brain bleeds

A new study by investigators from Mass General Brigham suggests that heavy alcohol use may lead to more severe brain bleeds and cause long-term brain vessel damage at a younger age.

5 Nov 2025

People with traumatic spinal cord injuries at higher risk of developing chronic health problems

A new study by investigators from Mass General Brigham shows that patients with traumatic spinal cord injuries (TSCI) are at a higher risk of developing a myriad of chronic health problems, regardless of age, location of the injury and prior health status.

4 Nov 2025

Hijacking cellular machinery within cancer cells to promote antitumor immunity

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells.

3 Nov 2025

Small increases in daily steps may slow Alzheimer’s progression

Increasing your steps by even a little bit may help slow down the progression of Alzheimer's disease among people at heightened risk, according to a new study.

3 Nov 2025

Home exercise alone highly effective for meniscal tear and osteoarthritis pain, says study

People with a meniscal tear and osteoarthritis prescribed home exercises with or without physical therapy reported substantial improvements in knee pain, according to a new study led by Mass General Brigham researchers.

30 Oct 2025

Study finds higher rate of stillbirths in the U.S. than previously reported

Stillbirths occur at a higher rate in the U.S. than previously reported, according to a new study led by researchers at Harvard T.H. Chan School of Public Health and Mass General Brigham.

27 Oct 2025

Study reveals how brain activity, energy use, and blood flow interact during sleep

Findings from Mass General Brigham investigators highlight the intricate interplay of diverse physiological processes as the brain shifts from wakefulness to sleep.

24 Oct 2025

Ingestible capsule developed for the diagnosis of acute mesenteric ischemia

Researchers led by investigators at Mass General Brigham and Massachusetts Institute of Technology have validated an ingestible capsule in preclinical models for the diagnosis of acute mesenteric ischemia, a condition caused by blocked or reduced blood flow to the intestines.

22 Oct 2025

Study reveals minimum steps for longevity and heart health benefits in older women

Tracking daily steps has become a staple exercise metric as smart devices keep count with ease. This physical activity stimulates bodily repair and maintenance, which is especially important as we age.