Metabolic Disease News and Research

RSS

Breast reduction surgery is linked to lower diabetes and heart risk

Findings suggest breast reduction surgery is associated with lower long-term diabetes and cardiovascular risks, enhancing women's metabolic health.

24 Mar 2026

Activating hypoxia signaling improves metabolism and bone health

Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the skeleton are often overlooked. Excess body fat can disrupt bone metabolism, weaken bone quality, and impair fracture repair.

17 Mar 2026

Skipping breakfast may raise metabolic syndrome risk

The link between skipping breakfast and metabolic syndrome highlights the need for dietary strategies to improve cardiometabolic health in at-risk populations.

16 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Drug combination shows greater weight loss while preserving muscle mass

A recent research study found that a combination of the GLP-1 receptor agonist semaglutide and bimagrumab, an antibody that blocks activin signaling pathways, results in greater weight loss while also preserving lean mass, such as skeletal muscle and connective tissue.

5 Mar 2026

How are GLP-1 drugs reshaping treatment for obesity, diabetes, and heart disease?

A comprehensive Lancet review synthesizes evidence from major clinical trials showing that GLP-1 receptor agonists and next-generation incretin therapies deliver substantial weight loss while reducing cardiovascular and kidney risks. Emerging dual, triple, and oral agents may further expand treatment options and improve outcomes across obesity, type 2 diabetes, and related metabolic diseases.

3 Mar 2026

New review explains how circular RNAs could unlock fat browning therapies

A Cell Death & Disease review synthesizes preclinical evidence that circular RNAs regulate adipose browning and metabolic pathways through microRNA interactions, protein binding, and organelle-linked stress mechanisms. It highlights their biomarker and therapeutic potential in obesity and type 2 diabetes while underscoring key translational challenges, including delivery specificity and human validation.

26 Feb 2026

Combining gene and biomarker screening for newborn health

For more than six decades, biomarker-based newborn screening has played a pivotal role in reducing infant mortality and long-term disability by enabling early detection of metabolic and endocrine disorders.

23 Feb 2026

Researchers show red blood cells drive better glucose tolerance at high altitude

Chronic hypoxia improves glucose tolerance in mice through insulin-independent mechanisms, with red blood cells acting as a major systemic glucose sink. Increased erythrocyte production and altered glycolytic flux help reduce circulating glucose while supporting oxygen delivery to tissues.

22 Feb 2026

Ozempic users continue treatment when weight loss works despite side effects

A study on Ozempic for weight loss reveals user satisfaction is driven by efficacy, despite common gastrointestinal side effects impacting treatment adherence.

13 Feb 2026

Type 2 diabetes and hypertension share a genetic link, study shows

Type 2 diabetes and high blood pressure share a genetic link, new research from the University of Surrey, UK and the Université de Lille, France shows.

10 Feb 2026

Defective fat cells drive metabolic disease in lipodystrophy

Many people may have a dim view of their fat tissue, yet scientists have come to recognize adipose as a necessary and metabolically active organ, carrying out many vital functions within the body.

9 Feb 2026

Researchers uncover a new cellular process linked to healthy aging

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health.

2 Feb 2026

Three daily servings of full-fat dairy do not worsen weight or blood markers

This randomized 12-week trial examined whether adding three daily servings of full-fat dairy to diets aligned with Canada’s Food Guide affects body weight, cardiometabolic markers, and nutrient intake in adults with overweight or obesity. Full-fat dairy intake did not adversely affect weight, body composition, or metabolic health and increased calcium and protein intake, supporting dietary compatibility rather than therapeutic benefit.

26 Jan 2026

New role for GLP-1 drugs: Improving survival in people with severe psychiatric disorders

This editorial argues that GLP-1 receptor agonists could substantially improve healthspan and reduce premature mortality in people with serious mental illnesses by targeting cardiometabolic risk rather than psychiatric symptoms alone. It highlights emerging evidence, safety considerations, and equity challenges that position GLP-1 RAs as a promising public health strategy for this high-risk population.

25 Jan 2026

Blood metabolites reveal who will develop type 2 diabetes years before diagnosis

This large prospective study integrated blood metabolomics, genetics, and lifestyle data to identify hundreds of metabolites associated with long-term risk of type 2 diabetes in initially healthy adults. A validated 44-metabolite signature improved risk prediction beyond conventional factors, offering insights into biological pathways and opportunities for earlier, more precise prevention.

18 Jan 2026