Mouse Model News and Research

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New PET imaging approach quantifies synaptic pathology in multiple sclerosis

A new PET imaging approach that measures synaptic density in the spinal cord provides a quantitative way to assess the brain's functional wiring in patients with multiple sclerosis.

2 Jun 2026

Modified stem cell therapy reverses new-onset Type 1 diabetes in mice

A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease.

2 Jun 2026

Microenvironmental CTHRC1 protein promotes colorectal cancer tumor growth

A new research paper was published in Volume 17 of Oncotarget on May 20, 2026, titled "Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer."

2 Jun 2026

How dysregulated collagen IV homeostasis causes cerebral microbleeds

Millions of older adults have tiny brain hemorrhages called cerebral microbleeds, which are strongly associated with dementia, cognitive decline, and stroke.

2 Jun 2026

New magnetic particle imaging ensures precision cell therapy injection tracking

Scientists at Johns Hopkins Medicine say they used a form of magnetic imaging to track cell therapy injections commonly used to treat certain autoimmune diseases and cancers.

2 Jun 2026

New mRNA treatment improves recovery following heart attacks

A heart attack is far from being an isolated, acute event. The consequences of an attack can cause serious and lasting damage, including heart failure.

1 Jun 2026

Mature intestinal cells regain stem cell behavior to trigger tumor growth

In a groundbreaking study, Stevens researchers show how colorectal cancers can evolve from mature intestinal cells that revert to stem cells.

1 Jun 2026

Justicia carnea extract alleviates oxidative stress in pancreatitis

Chronic pancreatitis is an inflammatory disease and is difficult to manage despite advancements in medical science.

1 Jun 2026

Gladstone scientists track exact routes used to clear brain waste

Think of the brain as if it were a house. Insulated from its environment, a house relies on complex networks-pipes, drains, and disposal systems-that interface with the outside world to keep the home functional on the inside.

29 May 2026

PET microplastics remain in lungs and worsen respiratory tract inflammation

Microplastics (MP) are the subject of intensive medical research, but little is yet known about their effects on the immune system.

29 May 2026

Scientists uncover shared gene signatures that reveal how mammals age

Researchers mapped more than 11,000 transcriptomes across mice, rats, macaques, and humans, revealing conserved molecular signatures of aging and mortality across tissues, species, and cell types. The study developed interpretable transcriptomic clocks that track age, mortality-related molecular change, chronic disease signals and responses to lifespan-altering interventions.

29 May 2026

Study uncovers a biological link between chronic oral inflammation and female fertility

Chronic oral inflammation may impair female fertility by triggering a systemic immune response that affects the ovaries.

28 May 2026

Virtual AI mouse tests nanomedicine without using living animals

When a tumor manages to nestle itself in the brain of a living being, it has - from the tumor's perspective - done something particularly clever.

28 May 2026

Researchers uncover possible cause of pain in neurofibromatosis type 1

Researchers at Cincinnati Children's have identified a potential new way to relieve chronic pain linked to neurofibromatosis type 1 (NF1), a genetic condition best known for causing tumors to grow along nerves.

26 May 2026

Chronic oral inflammation may impair female fertility and egg quality

Chronic oral inflammation may impair female fertility by triggering a systemic immune response that affects the ovaries.

26 May 2026

Senolytic therapy delays early disc degeneration in mouse model

Targeting senescent cells with dasatinib-quercetin preserves disc structure and modulates degeneration-associated pathways in a mouse model.

25 May 2026

Silica nanoparticles dampen early allergy signals in mouse mast cells

This in vitro study found that negatively charged SiO2 nanoparticles suppressed antigen-induced degranulation and activation-marker changes in IgE-sensitized mouse bone marrow-derived mast cells. By contrast, mTiO2 nanoparticles showed cytotoxic and pro-inflammatory effects, including enhanced DNP-induced IL-6 release, suggesting nanoparticle composition can shape early allergic immune responses.

24 May 2026