Pathophysiology News and Research

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Researchers develop machine learning models to identify biomarkers for chronic fatigue syndrome

When cells expire, they leave behind an activity log of sorts: RNA expelled into blood plasma that reveal changes in gene expression, cellular signaling, tissue injury and other biological processes.

11 Aug 2025

Alzheimer’s research reaches a critical tipping point

One-third of people older than 85 in the United States are estimated to live with Alzheimer's disease today, according to the National Institute on Aging.

8 Aug 2025

Copper oxide scaffolds show promise in treating traumatic brain injury

Traumatic brain injury (TBI) remains one of the leading causes of disability worldwide. Recent research has developed a novel electrospun scaffold loaded with copper oxide (CuO@PG), which aims to restore copper homeostasis and modulate inflammation in TBI.

7 Aug 2025

New Swiss study probes lingering fatigue after Legionnaires' disease

Researchers in Switzerland launched the LongLEGIO study to compare the long-term health impacts of Legionnaires’ disease and other bacterial pneumonias. Baseline data reveal key differences in comorbidities and quality of life between the groups, with follow-up underway.

4 Aug 2025

Novel insights from lymphoid structures: Lessons from colorectal cancer research

Discover how lymphoid structures and germinal centers provide powerful prognostic insights into colorectal cancer.

From TissueGnostics 31 Jul 2025

Targeting tumor cell stemness may hold the key to treating colon cancer more effectively

Colon cancer remains a major global health concern, ranking third among the most diagnosed cancers and leading causes of cancer-related death worldwide.

22 Jul 2025

Maybe it’s not just aging. Maybe it’s anemia.

Gary Sergott felt weary all the time. "I'd get tired, short of breath, a sort of malaise," he said. He was cold even on warm days and looked pale with dark circles under his eyes.

17 Jul 2025

Gut-brain axis in eating disorders offers new treatment potential

Understanding the gut-brain axis is key to addressing eating disorders. This study highlights microbiota's influence and emerging therapeutic approaches.

16 Jul 2025

Myopenia identified as key contributor to muscle loss in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects individuals across all ages and genders.

11 Jul 2025

Probiotics improve ovarian damage in premature menopausal mice

Findings suggest probiotics could mitigate ovarian decline and improve microbiota in POI mice, paving the way for new treatments in women's health.

4 Jul 2025

Aromatic benzaldehyde inhibits growth of therapy-resistant pancreatic cancer

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are necessary.

2 Jul 2025

Methylene blue emerges as an adjunct in septic shock

Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.

26 Jun 2025

More people survive heart attacks but face ongoing cardiac risks

In 1970, someone over the age of 65 hospitalized for a heart attack in the United States had about a 60% chance of leaving the hospital alive. Today, the survival rate is over 90%, with even better outcomes for younger patients.

26 Jun 2025

Targeting ADAM10 may offer hope for retinal disease treatment

New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina, which can cause vision loss or impairment.

25 Jun 2025

Equal access, unequal impact: Parkinson’s hits minorities harder in the UK

Researchers in East London found that South Asian and Black Parkinson’s disease patients experience more severe motor and cognitive symptoms than White patients. Despite similar access to diagnosis, disparities persist, highlighting the need for more inclusive and culturally sensitive care.

18 Jun 2025

Could a diabetes drug be the key to stopping Alzheimer’s?

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, linking diabetes and neurodegeneration.

17 Jun 2025

Scientists discover molecule that switches off brown fat activity

Obesity, diabetes and cardiovascular diseases are increasingly present in the population. Brown adipose tissue has a protective function against these prevalent diseases, as it burns calories and can produce body heat from fat.

16 Jun 2025

Understanding the role of astrocytes in depression and neuroinflammation

Major depressive disorder (MDD) is a mental health condition that negatively affects the mood of a person and causes a loss of interest in activities that were previously associated with happiness.

13 Jun 2025

Is that evening glass of wine really good for your heart?

A comprehensive AHA review finds overwhelming evidence that heavy alcohol use increases cardiovascular disease risk, while the benefits of low-to-moderate drinking remain unproven and uncertain. The authors recommend prioritizing proven heart-healthy habits over alcohol for cardiovascular protection.

10 Jun 2025

Spatial transcriptomics could transform musculoskeletal research

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

9 Jun 2025