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Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

Researchers performed genomic comparisons between alphacoronaviruses (αCoVs) and betacoronaviruses (βCoVs) originating from South Korean Bats.

28 Jun 2022

A cancer patient who had SARS-CoV-2 for over eight months

In a recent study posted to the medRxiv* pre-print server, researchers in Israel described the case of a severely immunocompromised cancer patient who developed a chronic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

28 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

Scientists characterize type I IFN response during SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, Canadian researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on interferon (IFN) response.

15 Jun 2022

Study identifies interesting sequence features in SARS-CoV-2 at start of COVID pandemic

In a recent study posted to the bioRxiv* pre-print server, researchers studied the sequence data from the coronavirus disease 2019 (COVID-19) cases from the Huanan seafood market in Beijing, China, to define the minor variant genome populations from the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pandemic.

14 Jun 2022

Stress protein in fibroblasts appears to be an attractive cancer drug target

A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

10 Jun 2022

The frequency and nature of RNA errors in both SARS-CoV-2 and its vaccine

A recent article demonstrated that SARS-CoV-2 mutants and vaccine variability stem from ribonucleic acid polymerase inaccuracy.

6 Jun 2022

Researchers reveal a possible biological mechanism connecting breast cancer and type 2 diabetes

Breast cancer and type 2 diabetes would seem to be distinctly different diseases, with commonality only in their commonality.

30 May 2022

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Researchers explored factors affecting substrate selection by the SARS-CoV-2 replicase.

24 May 2022

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

In a recent study posted to the medRxiv* preprint server, investigators in Singapore showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection elicited broadly specific virus-selective nasal resident CD8 and CD4 T cells.

24 May 2022

Researchers explore broad-based immunity against potentially pandemic-causing viruses

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Researchers revealed that native FokI relaxation might be induced, resulting in FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids.

27 Apr 2022

Structural Protein News and Research

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

A cancer patient who had SARS-CoV-2 for over eight months

SARS-CoV-2 evades natural killer cell cytotoxic responses

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

Scientists characterize type I IFN response during SARS-CoV-2 infection

Study identifies interesting sequence features in SARS-CoV-2 at start of COVID pandemic

Stress protein in fibroblasts appears to be an attractive cancer drug target

The frequency and nature of RNA errors in both SARS-CoV-2 and its vaccine

Researchers reveal a possible biological mechanism connecting breast cancer and type 2 diabetes

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

Researchers explore broad-based immunity against potentially pandemic-causing viruses

Characterizing SARS-CoV-2 non-structural protein 15 endoribonuclease variants

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Study investigates stress granule formation during infection with the human common cold coronavirus and SARS-CoV-2

Study identifies two new Omicron lineages associated with a resurgence in infections in South Africa

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

Longitudinal and proteome-wide analysis of antibodies in COVID-19 patients using a SARS-CoV-2 proteome microarray

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

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