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A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019

New promising approach repairs system of blood vessels following stroke

Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions.

25 Jun 2019

Switch that decides fate of cells from neural stem cells discovered

Neurons and astrocytes are prominent cell types in the cerebral cortex. Neurons are the primary information processing cells in the brain, whereas astrocytes support and modulate their functions.

24 Jun 2019

Researchers find a potential modulator in revascularization of pancreatic islets

The first cause of the loss of functionality in transplanted pancreatic islets is the low capacity to create new vessels to allow the arrival of nutrients in the cells.

20 Jun 2019

Study uncovers potential new way to prevent common pregnancy-related complications

About 1 in 10 pregnant women experience placenta abnormalities that lead to life-threatening preeclampsia (hypertension), preterm labor and fetal growth problems, but finding effective treatments to effectively prevent or reverse these conditions has so far been elusive.

19 Jun 2019

Novel lung map reveals new cells responsible for asthma

Researchers working on the Human Cell Atlas initiative have produced a detailed map of the human lungs that could lead to new treatments for asthma.

18 Jun 2019

Researchers develop DNA nanorobots that target breast cancer cells

According to the Mayo Clinic, about 20% of breast cancers make abnormally high levels of a protein called human epidermal growth factor receptor 2 (HER2).

17 Jun 2019

New implant technology safely minimizes injections for people with macular degeneration

In a clinical trial of 220 people with “wet” age-related macular degeneration, Johns Hopkins Medicine researchers, collaborators from many sites across the country, and Genentech in South San Francisco have added to evidence that using a new implant technology that continuously delivers medication into the eyes is safe and effective in helping maintain vision and reduces the need for injections in the eyes.

From Johns Hopkins Medicine 14 Jun 2019

Disease-modifying therapy for Alport syndrome still remains an unmet need

Alport syndrome is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure.

13 Jun 2019

Researchers identify macrophages' pathway to nurture PTEN-deficient glioblastoma

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

11 Jun 2019

'Eye-in-a-dish' model helps scientists to uncover 'surprising' AMD gene variant

Researchers have discovered a new genetic variant responsible for blood vessel dysregulation in the development of age-related macular degeneration (AMD).

29 May 2019

How pathogens are controlled under hypoxic conditions

Infected tissue has a low concentration of oxygen. The body's standard immune mechanisms, which rely on oxygen, can then only function to a limited extent.

24 May 2019

UW researchers use molecular tethers, chemical 'light sabers' for tissue engineering

Tissue engineering could transform medicine. Instead of waiting for our bodies to regrow or repair damage after an injury or disease, scientists could grow complex, fully functional tissues in a laboratory for transplantation into patients.

22 May 2019

Zebrafish may help researchers to use blood stem cells instead of bone marrow transplants

Blood diseases such as leukemia and lymphoma are currently treated with bone marrow transplants -- a transfer of blood stem cells from a healthy person to a patient in need.

21 May 2019

Honey from strawberry trees stops cell proliferation in colon cancer lines

Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped.

21 May 2019

New drug could alleviate symptoms of rare musculoskeletal condition

A new study shows a drug developed in conjunction with investigators at Indiana University School of Medicine to alleviate symptoms of a rare musculoskeletal condition is significantly more effective than conventional therapies.

20 May 2019

Broccoli contains an ingredient that could target the "Achilles’ heel" of cancers

A new study from the Beth Israel Deaconess Medical Center has come up with a new study that reveals that broccoli, Brussels sprouts, kale, cauliflower, cabbage and collard greens contain a substance that could inactivate a vital gene that plays a role in cancers.

19 May 2019

Novel approach uses magnetic beads for the treatment of preeclampsia

Preliminary laboratory tests show that functionalized magnetic beads successfully reduced blood levels of a harmful molecule that is elevated during preeclampsia, according to new research in the American Heart Association's journal Hypertension.

13 May 2019

HSS researchers provide better understanding of the cellular mechanisms driving rheumatoid arthritis

Newly identified subsets of cell types present in joint tissue in people with rheumatoid arthritis and how they interact may explain why only some people respond to existing medications, according to two studies by co-senior author Laura Donlin, PhD, Co-Director of the Derfner Foundation Precision Medicine Laboratory at Hospital for Special Surgery and collaborating colleagues.

10 May 2019

Blocking protein-digesting enzyme may help improve metabolic health

Blocking the action of an enzyme involved in protein digestion may improve metabolic health, according to a new study published ahead of print in the American Journal of Physiology--Gastrointestinal and Liver Physiology.

8 May 2019