Respiratory News and Research

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Previous SARS-CoV-2 infection may negate need for two vaccine doses

Researchers in the United States have shown that two doses of vaccine may not be necessary to protect against coronavirus disease 2019 (COVID-19) among people who have already been infected with the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Feb 2021

Study shows link between periodontitis and COVID-19 complications

COVID-19 patients are at least three times more likely to experience complications if they also have gum disease, according to research published today in the Journal of Clinical Periodontology, the official publication of the European Federation of Periodontology.

2 Feb 2021

What is the structure and function of SARS-CoV-2’s D614G spike mutation?

A team of researchers use a computational approach to integrate available data D614G SARS-CoV-2 spike mutation, exploring its structure and molecular mechanisms.

2 Feb 2021

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

A new preprint reports the efficacy of two repurposed drugs that could be useful against SARS-CoV-2 when supplemented with zinc.

2 Feb 2021

Pfizer-BioNTech vaccine shows promise against new SARS-CoV-2 variants

A team of researchers in the U.S. studied the Pfizer-BioNTech vaccine candidate - currently being rolled out in many parts of the world to high-risk individuals - to see if it still holds up against mutant strains of the virus and yielded encouraging results.

2 Feb 2021

ACE2 agonist C21 relieves respiratory difficulty in COVID-19

A new study describes a pilot study on the efficacy of a molecule called C21, which enhances the activity of the angiotensin-converting enzyme 2 (ACE2), the host cell receptor that facilitates viral entry.

2 Feb 2021

Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Over the past months, many potential antivirals against SARS-CoV-2 have been identified as deserving further development to target several viral proteins. A new study deals with one such molecule, the viral main protease (Mpro) inhibitor GC-376, and describes its efficacy in inhibiting virus-host interaction.

2 Feb 2021

Lower diagnostic threshold for fever in older people may help detect COVID-19 cases earlier

Researchers have explored heritable factors, age and body mass on temperature variation between humans. One notable finding is that the current threshold for detecting fever in older adults may be too high, precluding the ability to detect COVID-19 early on

2 Feb 2021

Researchers develop new modeling to map SARS-CoV-2 transmission dynamics in UK

Using a modified version of the susceptible-infectious-recovered (SIR) model to include effects of prevention measures, researchers show patterns in the increase and decrease of coronavirus disease 2019 (COVID-19) cases in the UK.

2 Feb 2021

Could ultra-low dose radiotherapy treat COVID-19-related pneumonia?

Researchers at the Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain, showed the potential benefit of treating COVID-19 pneumonia with ultra-low doses of radiotherapy.

2 Feb 2021

Differences in immune response to SARS-CoV-2 determine disease severity, study finds

Researchers investigate host responses to SARS-CoV-2, respiratory syncytial virus (RSV), and influenza virus (IV) in the nasal mucosa in children and adults.

2 Feb 2021

Johnson & Johnson SARS-CoV-2 vaccine shows promise in clinical trials

A new study shows that a single immunization with a low dose of the Ad26.COV2.S vaccine – also known as the ‘Johnson & Johnson vaccine’ – effectively protected against SARS-CoV-2 challenge in rhesus macaques.

2 Feb 2021

ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models

In the absence of effective therapeutics or preventives, vaccines have become the focus of attention. Though over 170 vaccines are in preclinical and about 60 in clinical development, very few are based on plasmid DNA technology. However, a new preprint research paper posted to the bioRxiv* server reports the immunogenicity of a DNA vaccine candidate.

2 Feb 2021

Why SARS-CoV-2 B.1.1.7 is more virulent

A new preprint research paper by scientists from Sweden and India attempts to provide a preliminary answer to these questions using computational modeling. The research, which appears on the bioRxiv* server, predicts increased virulence with the new variant. If validated, this could help public health authorities prepare for new variants' possible impact as they emerge.

2 Feb 2021

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2

Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear.

2 Feb 2021

Evidence that Long COVID-19 impacts children

The ongoing coronavirus 2019 (COVID-19) pandemic has caused over one hundred million reported infections, with over 2.23 million deaths worldwide. While most cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are asymptomatic or mild, some patients report long-haul symptoms, often severely debilitating in nature. However, it is unclear how many children are affected similarly.

2 Feb 2021

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), is associated with several clinical features common in autoimmune diseases as myalgias, arthralgias, fatigue, and rashes. COVID-19 patients also exhibit less common autoimmunity manifestations such as myositis, thrombosis, myocarditis, encephalitis, vasculitis, and arthritis.

1 Feb 2021

Urinary shedding of spike protein in COVID-19 patients

A team of scientists from the United States has recently revealed that about 25% of people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop renal complications and that the viral spike protein can be detected in the urine samples of these patients. The study is currently available on the medRxiv* preprint server.

1 Feb 2021

High national prevalence of SARS-CoV-2 with regional variability in England, REACT-1 survey finds

The REACT-1 survey conducted in the United Kingdom demonstrates a high average prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in England during January 2021. The survey also indicates that a sustained reduction in infection prevalence is urgently needed to avoid burden on healthcare systems and reduce coronavirus disease 2019 (COVID-19)-related mortality.

1 Feb 2021

Inhaling unfragmented hyaluronan improves lung function in COPD patients

Researchers at the National Institutes of Health and their collaborators found that inhaling unfragmented hyaluronan improves lung function in patients suffering from severe exacerbation of chronic obstructive pulmonary disease (COPD).

1 Feb 2021