Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Antibiotics provide no benefit in preventing recurrent wheezing in infants hospitalized with RSV

Antibiotics provide no benefit in preventing future recurrent wheezing in babies hospitalized with respiratory syncytial virus (RSV), according to a new study led by Washington University School of Medicine in St. Louis. And there is some evidence that antibiotics may make wheezing worse.

27 Feb 2022

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Insilico Medicine, an end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that it has dosed multiple healthy volunteers in Phase I clinical trial evaluating ISM001-055, the first anti-fibrotic small molecule inhibitor generated by Insilico's AI-powered drug discovery platform for idiopathic pulmonary fibrosis (IPF).

24 Feb 2022

Small breathing device could improve respiratory health and fitness levels of people with long COVID

New research presented at The Physiological Society's Long COVID: Mechanisms, Risk Factors, and Recovery on 22 – 23 February shows that a small handheld breathing device helped reduced breathlessness and improved physical fitness of people with long COVID.

23 Feb 2022

Cardiopulmonary limitations six months after surviving COVID-19

A recent prospective cohort study assessed the cardiopulmonary effects in patients six months after COVID-19 infection.

23 Feb 2022

Discovery could lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

22 Feb 2022

Mouse-adapted virus model to study persistent COVID induced lung disease

Researchers develop a mouse model to identify early biomarkers and test countermeasures needed to detect and prevent PASC.

21 Feb 2022

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Researchers investigated whether age-dependent changes in lung physiology make the elderly disproportionately susceptible to SARS-CoV-2 infection.

21 Feb 2022

Researchers highlight the extent to which NAFLD and diabetes jointly occur worldwide

Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, similar to the non-communicable diseases cancer, obesity, cardiovascular disease and diabetes.

18 Feb 2022

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

A new study discusses the state of current knowledge about the potential use of tea polyphenols in the prevention and treatment of COVID-19.

16 Feb 2022

Incomplete repair of the damaged lung may contribute to death from COVID-19 and non-COVID ARDS

Investigators studying lung cells have discovered that the normal repair process that occurs after lung disease or injury appears to be incomplete but still ongoing in patients who died of COVID-19 and non-COVID acute respiratory distress syndrome (ARDS).

15 Feb 2022

Study suggests that epigenetic memory in innate immune cells could be the key to explaining long COVID

A new study may provide a partial explanation for the long-term immunologic phenomena associated with COVID-19.

15 Feb 2022

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

14 Feb 2022

Research lays the foundation for developing obesity drugs based on enhancing β-AR signaling

Following up on a 2018 study that identified an epigenetic modifier known as histone deacetylase 11 (HDAC11) as a potential therapeutic target for treating obesity and diabetes, researchers from the University of Colorado School of Medicine have published new research that finds HDAC11 regulates G protein-coupled receptors (GPCRs) called beta-adrenergic receptors (β-ARs).

14 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Testes found to be a viral reservoir for SARS-CoV-2 replication

In a recent study posted to the medRxiv* pre-print server, researchers used a suite of methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the testis of patients who died from coronavirus disease 2019 (COVID-19) to gain insights into SARS-CoV-2 tropism inside testis and its impact on male fertility.

13 Feb 2022

The impact of COVID-19 on people with systemic autoimmune rheumatic diseases

A survey demonstrated that patients with systemic autoimmune rheumatic diseases commonly experience augmented disease severity and disrupted treatment regimens of disease-modifying antirheumatic drugs after acute COVID-19 course.

11 Feb 2022

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

The human body responds to stress, from the everyday to the extreme, by producing a hormone called cortisol.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

Post-transplantation lung microbiome profiles can provide prognostic information

Lung transplantation is a life-saving intervention in cases of severe respiratory failure. A feared and common complication following a lung transplant is chronic deterioration in lung function (CLAD/Chronic Lung Allograft Dysfunction).

7 Feb 2022

Fibrosis News and Research

Further Reading

Antibiotics provide no benefit in preventing recurrent wheezing in infants hospitalized with RSV

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Small breathing device could improve respiratory health and fitness levels of people with long COVID

Cardiopulmonary limitations six months after surviving COVID-19

Discovery could lead to new treatment approach for people with alcohol-associated liver disease

Mouse-adapted virus model to study persistent COVID induced lung disease

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Researchers highlight the extent to which NAFLD and diabetes jointly occur worldwide

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

Incomplete repair of the damaged lung may contribute to death from COVID-19 and non-COVID ARDS

Study suggests that epigenetic memory in innate immune cells could be the key to explaining long COVID

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Research lays the foundation for developing obesity drugs based on enhancing β-AR signaling

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Testes found to be a viral reservoir for SARS-CoV-2 replication

The impact of COVID-19 on people with systemic autoimmune rheumatic diseases

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

Post-transplantation lung microbiome profiles can provide prognostic information

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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