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New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

Study reveals shared genetic roots across multiple psychiatric disorders

Distinct psychiatric disorders have more in common biologically than previously believed, according to the largest and most detailed analysis to date of how genes influence mental illness.

11 Dec 2025

Study reveals how Ebola and Marburg viruses damage the human gut

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body.

11 Dec 2025

Researchers discover the enzyme responsible for chromothripsis in cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and become resistant to treatment.

11 Dec 2025

Teenagers with body image issues may develop eating disorders and depression later

Teenagers who are unhappy with their bodies are more likely to develop symptoms of eating disorders and depression in early adulthood, according to a new study led by UCL researchers.

11 Dec 2025

Shared genetic roots of 14 psychiatric disorders revealed

Researchers from the Psychiatric Genomics Consortium (PGC) report that most genetic influences on mental illness are shared across diagnostic categories, revealing a more interconnected biological landscape than traditional classifications suggest.

11 Dec 2025

Disrupted genome architecture drives lymphoma development

Cancer isn't just about broken genes-it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services.

10 Dec 2025

Discovery links human M cells to early steps of celiac disease

The human small intestine absorbs nutrients while protecting us from potentially harmful microbes. One of the cell types that plays a key role in this protection is the microfold cell, or M cell.

10 Dec 2025

Study elucidates novel mitochondrial mechanisms underlying anti-aging and longevity

As life expectancy continues to climb globally, the focus of many people has moved from longevity alone to living in good health.

10 Dec 2025

AI model improves recurrence risk stratification in HR-positive, HER2-negative breast cancer

An artificial intelligence (AI) model created by integrating clinical, molecular, and histopathological data significantly improved recurrence risk stratification in hormone receptor (HR)-positive, HER2-negative breast cancer, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Study offers a unified biological model to explain the causes of autism

A new University of California San Diego School of Medicine study offers a unified biological model to explain how genetic predispositions and environmental exposures converge to cause autism spectrum disorder (ASD).

10 Dec 2025

Surprising new function of immune cells uncovered: Excess weight loss prevention

Researchers at the University of California San Diego School of Medicine have uncovered a surprising new function for immune cells: preventing excess weight loss.

10 Dec 2025

Machine learning models can help diagnose ALS earlier from a blood sample

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests.

10 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

AI-driven method uncovers genetic interactions that fuel cancer progression

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

Australian researchers pinpoint specific genetic changes linked to severe AMD

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD).

9 Dec 2025

Everyday PFAS exposure alters placental function in early pregnancy

This study measured real-life PFAS concentrations in first-trimester human placentas and used these data to create a pregnancy-relevant PFAS mixture. In 3D trophoblast spheroid models, the mixture altered invasion, hormone secretion, and gene expression without broadly reducing viability at environmentally relevant doses.

8 Dec 2025

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

A study funded in part by the National Institutes of Health (NIH) has revealed important insights into the genetics of deposits in the eye, known as reticular pseudodrusen (RPD), that are linked to greater risk of vision loss among people with age-related macular degeneration (AMD).

8 Dec 2025

Industrial and farm chemicals quietly alter the balance of gut microbes

This study systematically screened over 1,000 agricultural and industrial chemicals and found that many can inhibit human gut bacteria in vitro. Beyond antimicrobial effects, these chemicals act as selective pressures that can reshape microbial competition, tolerance mechanisms, and metabolic pathways.

8 Dec 2025