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How blood iron levels shape the pace of biological aging

Researchers examine the role of blood iron levels in DNA methylation-based measurements of biological aging.

29 Apr 2025

Humanized antibody dismantles metabolic barrier as a potential cancer immunotherapy

A Ludwig Cancer Research study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses.

28 Apr 2025

MASLD in children linked to increased mortality and chronic complications

Researchers from University of California San Diego have found that children diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) are at significantly increased risk of premature death and serious long-term health complications.

28 Apr 2025

New blood test can improve heart disease risk prediction

For almost 60 years, measuring cholesterol levels in the blood has been the best way to identify individuals at high risk of cardiovascular disease.

28 Apr 2025

Blood proteins offer early warning for liver disease

Scientists have identified five specific blood proteins that can accurately predict a person's risk for developing a serious form of liver disease as early as 16 years before they experience symptoms, enabling early intervention and possible prevention and treatment, according to a study to be presented at Digestive Disease Week (DDW) 2025.

25 Apr 2025

Researchers pioneer method to measure liver tissue stiffness without damage

Researchers in South Korea have developed an organoid disease model and non-destructive stiffness analysis technology for evaluating the efficacy of new drugs for fatty liver disease.

25 Apr 2025

Four specific gene mutations linked to development and progression of lethal stomach cancers

Researchers using next-generation DNA sequencing have identified four specific genes whose mutations are linked to the development and progression of lethal stomach cancers.

25 Apr 2025

Serum hsa_circ_101555 as a promising biomarker for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) represents the most prevalent malignancy in Egypt and globally. However, non-invasive diagnostic/prognostic biomarkers for early detection of HCC are still lacking. Circular RNAs (circRNAs) are one of the promising biomarkers.

24 Apr 2025

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

24 Apr 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Scientists uncover why Lyme disease symptoms may linger after treatment

Symptoms that persist long after Lyme disease is treated are not uncommon - a 2022 study found that 14% of patients who were diagnosed and treated early with antibiotic therapy would still develop Post Treatment Lyme Disease (PTLD).

23 Apr 2025

Research offers new hope in the fight against antibiotic-resistant bacteria

Antibiotic resistance is a serious threat to public health. When antibiotics don't work, we risk not being able to treat many types of infections and people who would previously have been cured, can die.

23 Apr 2025

DT-109 shows promise in treating atherosclerosis and liver disease

A drug candidate, previously successful at treating severe fatty liver disease, reduces atherosclerosis - a primary driver of cardiovascular death worldwide - in large mammals, a study suggests.

23 Apr 2025

Mursla Bio receives FDA breakthrough device designation for EvoLiver test

Mursla Bio, a leader in Extracellular Vesicle (EV) science on a mission to significantly improve cancer outcomes for at-risk patients through the power of Dynamic Biopsy technology, today announced that the US Food and Drug Administration (FDA) has granted Breakthrough Device Designation to its lead product, EvoLiver™.

23 Apr 2025

Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance. Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism remains unclear.

22 Apr 2025

Obesity alters the rhythm of liver’s starvation response

Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network.

22 Apr 2025

Plastic additives found in 85% of foods raise concern for infant health

Researchers assessed plasticizer levels in foods typical of the Spanish diet and found widespread contamination, with infants showing the highest exposure. Certain additives, like DEHP, exceeded safety thresholds in high-exposure scenarios.

21 Apr 2025

Researchers find immune system proteins involved in severe cases of schistosomiasis

New insights into the mechanisms that cause more severe cases of schistosomiasis - a disease caused by parasitic worms and second only to malaria in terms of potential harm - have been revealed by researchers at Penn State.

21 Apr 2025

Ursolic acid modulates estrogen conversion to alleviate MASLD inflammation

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been escalating annually, positioning it as the leading cause of chronic liver disease worldwide.

21 Apr 2025

Natural supplement linked to slower biological aging and improved health

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 14, 2025, titled "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial."

21 Apr 2025